Nanometer composite material and applications of nanometer composite material in tracing of lymph nodes

A nano-composite material and nano-material technology, which can be used in medical preparations containing active ingredients, wave energy or particle radiation treatment materials, drug combinations, etc.

Pending Publication Date: 2018-08-28
NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The commercial nano-carbon suspension consists of nano-activated carbon and dispersant polyvinylpyrrolidone. The surface of nano-carbon is negatively charged and cannot be specifically recognized and phagocytized by scavenger receptors and mannose receptors on the surface of macrophages. Therefore, The efficiency of macrophag

Method used

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  • Nanometer composite material and applications of nanometer composite material in tracing of lymph nodes
  • Nanometer composite material and applications of nanometer composite material in tracing of lymph nodes
  • Nanometer composite material and applications of nanometer composite material in tracing of lymph nodes

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0081] Embodiment 1: the preparation of core nanomaterial

[0082] core material bTiO 2 Preparation of -1

[0083] According to the method in the literature (Energy Environ.Sci., 2013, 6, 3007–3014), the aluminum reduction black TiO was prepared 2 , denoted as the kernel bTiO 2 -1.

[0084] core material bTiO 2 Preparation of -2

[0085] Take 0.1mol / L titanium tetrachloride (TiCl 4 ) hydrochloric acid solution 50mL, slowly added dropwise to 90mL ultrapure water, stirred and hydrolyzed for 8 hours under ice bath conditions. After the hydrolysis, the reaction solution was placed in a dialysis bag, dialyzed in pure water, and the water was changed every 3 hours, and the water was changed 4 times in total to obtain TiO 2 precursor solution. TiO 2 100mL of the precursor solution was placed in a reaction kettle and heated at 180°C for 10 hours to obtain TiO 2 Nanoparticles. TiO 2 After drying the nanoparticles at a high temperature of 60°C, TiO 2 Nanoparticle powder...

Embodiment 2

[0098] Example 2: Sample bTiO 2 -1- Preparation of hyaluronic acid nanocomposites

[0099] Take the kernel bTiO 2 - 50 mg of nanomaterials, dispersed in 200 mL of pure water, ultrasonically dispersed for 30 minutes. Then 200 ml of 1 mg / mL hyaluronic acid solution was added, and the reaction was stirred for 24 hours. After the reaction, centrifuge at 12,000 rpm for 10 minutes to remove excess hyaluronic acid and obtain the sample bTiO 2 -1- Hyaluronic acid composite nanoparticles.

Embodiment 3

[0100] Example 3: Sample bTiO 2 -1-mSiO 2 - Preparation of ICG-PEI nanocomposite

[0101] Take the kernel bTiO 2 -1 50 mg of nanomaterials was dissolved in 100 mL of pure water, and after ultrasonic dispersion for 30 minutes, solution A was obtained. Add 100 mg cetyltrimethylammonium bromide (abbreviated as CTAB) to solution A, stir and heat for 30 minutes to dissolve CTAB. After CTAB was dissolved, 3 mL of ethanol and 150 μL of NaOH (2M concentration) were added to the reaction system, and heated to 70°C. Add 200 μL tetraethyl orthosilicate (TEOS) to the reaction solution, stir the reaction for 1 hour, then add NH 4 NO 3 30 mg, after being incubated at 60°C for 1 day, centrifuged and washed at 12,000 rpm to obtain bTiO 2 -1-Mesoporous silicon composite. Take bTiO 2 -1-Mesoporous silica (abbreviated as mSiO 2 ) 50 mg of the composite material was dispersed into 100 mL of pure water, ultrasonically dispersed for 10 min, and then 20 ml of 0.1 mg / mL indocyanine green (a...

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Abstract

The present invention discloses a nanometer composite material, which can be used as a lymph node tracer and is easily phagocytized by macrophages in lymphatic vessels, wherein the traced lymph nodesare black and emit fluorescence under the irradiation with excitation light so as to be easily discovered and cleared, and undiscovered tiny lymph nodes can be monitored and ablated by combining the irradiation of tumors and surrounding tissues with near-infrared light and the imaging of tumors and surrounding tissues with near-infrared thermal imager so as to completely clear the lymph nodes around the tumor tissues. The nanometer composite material sequentially comprises an inner core and at least a coating layer from inside to outside, wherein the inner core is black, and each layer of thecoating layer contains at least one selected from a fluorescent material, a fluorescent dye and an organic macromolecule polymer. The invention further discloses a preparation method of the nanometercomposite material, and a lymph node tracer containing the nanometer composite material and/or the inner core.

Description

technical field [0001] The application relates to an application of a compound in tracing lymph nodes, a nanocomposite material containing the compound, and a preparation method of the nanocomposite material. Background technique [0002] Lymphatic metastasis is the main way for some malignant tumors such as breast cancer and gastric cancer to metastasize. Therefore, in malignant tumor surgery, it is more and more important to remove the lymph nodes around the tumor tissue. Whether the involved lymph nodes can be completely removed plays a decisive role in the prognosis of malignant tumors. However, lymph nodes vary in size, and the diameter of tiny lymph nodes is about 2 mm. It is difficult to distinguish them from normal tissues with the naked eye during surgery. Therefore, it is necessary to trace the tiny lymph nodes around malignant tumors during surgery to effectively treat them clear. At present, the nano-carbon suspension with a particle size of about 21nm is mainl...

Claims

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Application Information

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IPC IPC(8): A61K49/00A61K41/00A61P35/00
CPCA61K41/0052A61K49/0054A61K49/0093
Inventor 吴爱国任文智邹瑞芬
Owner NINGBO INST OF MATERIALS TECH & ENG CHINESE ACADEMY OF SCI
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