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Microneedle patch for whitening and freckle removing and preparation method of microneedle patch

Inactive Publication Date: 2018-10-16
XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although these skin care products added with heavy metals can achieve immediate results, skin irritation, erythema, edema, and a series of systemic symptoms caused by skin absorption into the human body after using excessive heavy metal products, such as neurasthenia, fatigue, Anemia and other symptoms
The main defect of most whitening and freckle skin care products is that the effect is slow and inaccurate, and it is easy to cause skin problems such as allergies
On the other hand, due to the obstruction of the stratum corneum of the skin, skin care products that are only applied on the skin surface are difficult to be truly absorbed, and the cosmetic effect is also greatly reduced.

Method used

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  • Microneedle patch for whitening and freckle removing and preparation method of microneedle patch
  • Microneedle patch for whitening and freckle removing and preparation method of microneedle patch
  • Microneedle patch for whitening and freckle removing and preparation method of microneedle patch

Examples

Experimental program
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Effect test

Embodiment 1

[0032] Embodiments of the present disclosure provide a microneedle patch for whitening and freckle removal, such as figure 1 As shown, the microneedle patch includes a main support component and functional components, the main support component forms a base and needles, and the functional components are dispersed in the base and needles. The main support component is a hyaluronic acid solution made of biocompatible hyaluronic acid. The functional components are composed of the following components by weight percentage: 10% bearberry leaf extract, 15% pearl powder, 5% licorice extract, 5% angelica extract, 10% bletilla striata extract, 10% coix seed extract, 10% lemon extract, 10% niacinamide, 5% glycerin, 5% Vitamin E, 5% Ascorbic Acid, 5% Allantoin and 5% Kojic Acid. The needles of the microneedle patch are pyramidal, conical or quasi-conical, the height of the needles is 50 μm, the base diameter is 50 μm, and the distance between the tips of two adjacent needles is 100 μm. ...

Embodiment 2

[0040] An embodiment of the present disclosure provides a microneedle patch for whitening and removing freckles, which includes a main support component and functional components, the main support component constitutes a base and needles, and the functional components are dispersed in the base and the needles. The main support component is a chitosan solution made of biocompatible chitosan, and the functional components are composed of the following components by weight percentage: 30% bearberry leaf extract, 25% pearl powder, 3% licorice extract, 2% angelica extract, 5% bletilla striata extract, 5% coix seed extract, 15% lemon extract, 5% niacinamide, 3% glycerin, 1% Allantoin, 1% ascorbic acid and 5% Tween 20. The needles of the microneedle patch are pyramidal, conical or quasi-conical, the height of the needles is 500 μm, the base diameter is 500 μm, and the distance between the tips of two adjacent needles is 1000 μm.

[0041] The preparation method of the microneedle pat...

Embodiment 3

[0048] An embodiment of the present disclosure provides a microneedle patch for whitening and removing freckles. The microneedle patch includes a main support component and functional components. The main support component constitutes a base and needles, and the functional components are dispersed in the base and the needles. The main support component is a maltose solution made of biocompatible maltose, and the functional components are composed of the following components by weight percentage: 20% bearberry leaf extract, 20% pearl powder, 5% licorice Extract, 5% Angelica Extract, 5% Bletilla striata Extract, 10% Coix Seed Extract, 15% Lemon Extract, 10% Niacinamide, 3% Glycerin, 2% Ascorbic Acid, 2% of salicylic acid and 3% Tween 40. The needles of the microneedle patch are pyramidal, conical or quasi-conical, the height of the needles is 1000 μm, the base diameter is 1000 μm, and the distance between the tips of two adjacent needles is 2000 μm.

[0049] The preparation met...

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Abstract

An embodiment of the invention discloses a microneedle patch for whitening and freckle removing and a preparation method of the microneedle patch and relates to the field of skin care products. The microneedle patch contains a main supporting component and effective components, wherein the main supporting component is prepared from a degradable material, and the effective components contain the following elements in percentage by weight: 10%-30% of bearberry leaf extract, 15%-25% of pearl powder, 3%-5% of licorice extract, 2%-5% of radix angelicae sinensis extract, 5%-10% of rhizoma bletillaeextract, 5%-10% of semen coicis extract, 10%-15% of lemon extract, 5%-10% of nicotinamide and 10%-25% of an auxiliary additive. The microneedle patch effectively penetrates the stratum corneum barrierof the skin and with the rapid dissolution of the degradable material in the skin, the effective components may be absorbed by the dermis layer quickly; the microneedle patch has effects of promotingblood circulation, nourishing the skin, effectively inhibiting generation and accumulation of melanin in the skin, accelerating decomposition and metabolism of melanin and whitening the skin.

Description

technical field [0001] The present disclosure relates to the field of skin care products, in particular to a microneedle patch for whitening and freckle removal and a preparation method thereof. Background technique [0002] At present, although there are many kinds of whitening and anti-freckle skin care products on the market, there are few ideal products. Some products add heavy metal mercury or lead. Mercury compounds can whiten the skin by inhibiting the activity of tyrosinase in the skin and reducing the production of melanin. , heavy metal lead and lead compounds have a certain concealing effect, and can also be used for whitening and concealing. Although these skin care products added with heavy metals can achieve immediate results, skin irritation, erythema, edema, and a series of systemic symptoms caused by skin absorption into the human body after using excessive heavy metal products, such as neurasthenia, fatigue, Anemia and other symptoms. The main defect of m...

Claims

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Application Information

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IPC IPC(8): A61K8/98A61K8/9794A61K8/9789A61K8/67A61K8/02A61Q19/00A61Q19/02
CPCA61K8/0204A61K8/675A61K8/9789A61K8/9794A61K8/987A61K2800/782A61K2800/91A61Q19/00A61Q19/02
Inventor 陶娟杜虹瑶朱锦涛李钰策张连斌柳佩董励耘李军朱今巾
Owner XIEHE HOSPITAL ATTACHED TO TONGJI MEDICAL COLLEGE HUAZHONG SCI & TECH UNIV
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