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Paeoniflorin/synephrine composition for treating gastrointestinal dysfunction or irritable bowel syndrome and application thereof

A technology for irritable bowel syndrome and gastrointestinal dysfunction, which is applied in the field of natural pharmaceutical compositions to achieve the effects of clear chemical composition, reduced clinical dosage, and stable and controllable drug quality

Inactive Publication Date: 2018-11-09
NANJING XINTONG RUIYI MEDICINE SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] At present, there is a lack of a paeoniflorin / synephrine composition with clear ingredients and significant curative effect for the treatment of gastrointestinal disorders or irritable bowel syndrome and its application

Method used

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  • Paeoniflorin/synephrine composition for treating gastrointestinal dysfunction or irritable bowel syndrome and application thereof
  • Paeoniflorin/synephrine composition for treating gastrointestinal dysfunction or irritable bowel syndrome and application thereof
  • Paeoniflorin/synephrine composition for treating gastrointestinal dysfunction or irritable bowel syndrome and application thereof

Examples

Experimental program
Comparison scheme
Effect test

experiment example 1

[0076] Effect of Composition on Visceral Hypersensitivity in Irritable Bowel Syndrome Model Rats

[0077] 1. Experimental animals and medicines are provided through legal channels. Pinaverium Bromide Tablets 50mg / tablet (Abbott Products SAS) for experiments; paeoniflorin (98%), synephrine (98%), glycyrrhizinic acid (95%), naringin (purity 98%), orange peel for experiments Glycoside (98%), isoliquiritin (98%), liquiritin (98%), and neohesperidin (98%) were provided by Nantong Feiyu Biotechnology Company. The relevant extracts used in the experiment were prepared by ourselves, paeoniflorin extract (content greater than or equal to 20%), synephrine (amount greater than or equal to 10%), glycyrrhizic acid (content greater than or equal to 20%), naringin (content greater than or equal to 20%), hesperidin (content greater than or equal to 20%), neohesperidin extract (content greater than or equal to 20%), liquiritin (content greater than or equal to 10%), isoliquiritin (content gr...

experiment example 2

[0130] Effects of the composition on 5-HT signaling pathway and TRPV1 in visceral hypersensitive rats.

[0131] 1. Experimental animals, medicines, modeling, and test product preparation: the same as in Experimental Example 1.

[0132] 2. Experimental method

[0133] Rat colon tissue sample collection: 2 hours after the last gavage, the rats were executed by decapitation, and 3 segments of the colon 3 cm above the anus were taken, each segment 1-2 cm, washed with normal saline and PBS buffer solution (pH 7.4) respectively , blotted dry with filter paper, accurately weighed, quickly frozen with liquid nitrogen, and stored at -80°C for later use.

[0134] 5-HT, 5-HT3R, 5-HT4R, TPH1, and SERT protein expression levels in rat colon were measured by enzyme-linked immunosorbent assay (ELISA). The rat colon tissue pieces were washed with PBS buffer, and the tissue was homogenized by adding appropriate saline. slurry, and centrifuged to obtain the supernatant. According to the inst...

experiment example 3

[0158] Regulation of Gastrointestinal Disorder Rats Induced by Reserpine

[0159] 1. Animals and reagents are the same as in Experimental Example 1.

[0160] 2. Animal grouping and dosage: (1) Normal group was injected intraperitoneally with equal volume of normal saline, and at the same time fed with equal volume of distilled water; (2) Model group: intraperitoneally injected with reserpine 0.5 mg / kg, and simultaneously fed with equal volume of distilled water (3) Positive group: intraperitoneal injection of reserpine 0.5mg / kg, and at the same time, 50 mg / kg of Suliqenone was administered; (4) sample group: intraperitoneal injection of reserpine 0.5mg / kg, and simultaneously, the test samples were administered (with experimental example one). Each group was administered continuously for two weeks. The feces and signs of the rats were observed at any time, and the body weight and food intake of the rats were weighed every day. The following samples were collected according t...

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Abstract

The invention discloses a paeoniflorin / synephrine composition for treating gastrointestinal dysfunction or irritable bowel syndrome and application thereof. The paeoniflorin / synephrine composition fortreating gastrointestinal dysfunction or irritable bowel syndrome contains at least two active ingredients of paeoniflorin and synephrine. The invention selectively adopts a combination of natural components, wherein the combination has synergistic regulation and multi-target rectification effect on 5HT signaling pathway, and puts forward the fact that the optimum composition of natural components has better effect than original single ingredient or compounded traditional Chinese medicine extracts. On the basis, the combination ratio is further optimized to achieve the best results.

Description

technical field [0001] The invention relates to a natural medicine composition, in particular to a paeoniflorin / synephrine composition for treating gastrointestinal dysfunction or irritable bowel syndrome and its application. Background technique [0002] Gastrointestinal dysfunction is a common clinical functional intestinal disease, accounting for about 40-60% of gastrointestinal diseases. Among them, irritable bowel syndrome (irritable bowel syndrome, IBS) is a common non-organic intestinal dysfunction disease of the digestive tract, which has the clinical characteristics of chronic recurrent attacks. The prevalence in adults ranges from 10% to 22%. Its main clinical manifestations are abdominal pain, diarrhea, constipation and other digestive system symptoms without organic lesions, and its etiology is gastrointestinal dysfunction. There is currently no effective treatment for this disease. [0003] Since modern medicine has not yet clarified its pathology and pathoge...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K31/137A61P1/00A61K31/704A61K31/7034
CPCA61K31/137A61K31/7034A61K31/704A61K31/7048A61P1/00A61K2300/00
Inventor 杨星昊张婧娴
Owner NANJING XINTONG RUIYI MEDICINE SCI & TECH
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