Garcinia mangostana L. extract for treatment of gout and preparation method thereof

Abstract

The invention relates to Garcinia mangostana L. fruit pericarp extract for treatment of gout and a preparation method thereof. The preparation method includes the following steps: using Garcinia mangostana L. fruit pericarp as a raw material, and carrying out extracting, concentrating and enriching on the Garcinia mangostana L. fruit pericarp, so at to obtain the Garcinia mangostana L. fruit pericarp extract for treatment of gout. Studies show that Garcinia mangostana L. fruit pericarp extract I and II have a strong uric acid-reducing effect, the uric acid level in serum of hyperuricemia miceinduced by oteracil potassium can be significantly reduced by intragastric administration of the Garcinia mangostana L. fruit pericarp extract I (20 mg / kg) or II (20 mg / kg); and fresh garcinia Mangostana L. fruit pericarp extract I and II and dried Garcinia Mangostana L. fruit pericarp extract I and II can significantly reduce the serum uric acid levels. In vitro studies show that the mechanism ofuric acid reducing action of the Garcinia mangostana L. fruit pericarp extract II is related to inhibition of uric acid production, while the mechanism of uric acid reducing action of the Garcinia mangostana L. fruit pericarp extract I is related to promotion of uric acid excretion. Obvious toxic and side effects and animal deaths are not observed in mice after intragastric administration of theGarcinia mangostana L. fruit pericarp extract I (5.0 g / kg) and II (5.0 g / kg), respectively. Therefore, both the Garcinia mangostana L. fruit pericarp extract I and II can be used to prepare oral drugsand health products to resist gout and hyperuricemia and to treat diseases related to hyperuricemia.

Description

technical field [0001] The invention relates to a mangosteen peel extract, a preparation method and an application thereof, and belongs to the technical field of medicine. Background technique [0002] Mangosteen (Garcinia Mangostana L.), also known as mangosteen, mangosteen, mangosteen, mangosteen, phoenix fruit, is the fruit of the evergreen tree plant mangosteen of the genus Garcinia in the family Guttiferae. The reputation of "green fruit" is known as the "Queen of Fruits". Mangosteen grows in dense forests or sparse forests in hilly areas, hillsides, and valleys. It is native to the Malay Peninsula and the Malay Archipelago. It is more cultivated in Southeast Asia such as Malaysia, Thailand, the Philippines, and Myanmar. In my country, Guangdong, Guangxi, Fujian, and Yunnan It is also planted in other provinces. Mangosteen pulp is rich in dietary fiber, sugar, vitamin B, various amino acids, protein, fat and rich minerals, has high edible value, and has a good nursing ...

AI Technical Summary

Problems solved by technology

However, the treatment of gout mainly relies on uricosuric drugs (such as probenecid, benzbromarone, etc.) and xanthine oxidase inhibitors (such as allopurinol, febuxol, etc.) Tan), very limited, and traditional uricosuric drugs are often accompanied by side effects such as rash, fever, and kidney damage, while xanthine oxidase inhibitor allopurinol is the most commonly used xanthine oxidase inhibitor in clinical practice. It also has adverse reactions such as liver and bone marrow toxicity and allergies, which limits its safe use to a certain extent; febuxostat is a new drug approved by the US FDA in 2009, with good curative effect, but the long-term effects and side effects still need to be further developed Observed

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