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Acne removal co-transporting nano-composition, preparation method thereof and application of nano-composition

A nano-composition and anti-acne technology, which is applied in the direction of drug combinations, pharmaceutical formulas, cosmetic preparations, etc., can solve the problems of unsatisfactory anti-acne effect, insoluble in water, easy to irritate the skin, etc., and achieve safe and efficient elimination of acne, Effect of repairing skin barrier function and improving skin immunity

Inactive Publication Date: 2018-11-13
WUHAN BEST CARRIER NANO TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, most of the above active substances (such as kaempferol, baicalin, magnolol, etc.) are insoluble in water, and easily oxidized and discolored, which is inconvenient to use in cosmetics; acid and its derivatives, etc.) are easy to irritate the skin and mucous membranes, and can also react with proteins in body tissues, so that its application in cosmetics is limited to a certain extent
[0004] At present, due to the restrictions on relevant ingredients and dosage by Chinese laws and regulations, there are few reports on nano-packages for acne treatment, and most of them have shortcomings such as single efficacy, slow effect, and unsatisfactory anti-acne effect.

Method used

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  • Acne removal co-transporting nano-composition, preparation method thereof and application of nano-composition
  • Acne removal co-transporting nano-composition, preparation method thereof and application of nano-composition
  • Acne removal co-transporting nano-composition, preparation method thereof and application of nano-composition

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preparation example Construction

[0048] The present invention provides a preparation method of the anti-acne co-delivery nanocomposition described in the above scheme, which includes the following steps:

[0049] In the present invention, the oil secretion-inhibiting actives, bacteriostatic agents, anti-sensitizers, exfoliating actives, emulsifiers, co-emulsifiers, stabilizers, and complex lipids are dissolved to obtain an oil phase; The temperature is preferably 40 to 70°C, more preferably 45 to 60°C; the dissolution time is preferably 10 to 40 minutes, more preferably 15 to 30 minutes.

[0050] In the present invention, the desalinated acne marks active substance and water are mixed, stirred and dissolved to obtain an aqueous phase; the temperature of the stirring and dissolution is preferably 40 to 70°C, more preferably 45 to 60°C; the dissolution time is preferably 10 to 25 minutes, more preferably 11 to 15 minutes.

[0051] In the present invention, after the oil phase and the water phase are obtained, the wat...

Embodiment 1

[0063] Combine 0.1% kaempferol, 10.0% magnolol, 0.1% glycyrrhetinic acid, 8.0% salicylic acid, 0.5% butylated hydroxytoluene, 8.0% PEG-8 caprylic / capric glycerides, 12.0% cetearyl alcohol Polyether, 10.0% coco glucoside, 8.0% 1,3-butanediol, 6.0% polyethylene glycol-400, 5.0% glycerin, 3.0% isopropyl myristate, 1.0% cetyl alcohol , 1.0% polyethylene glycol glyceryl stearate, stirred and dissolved in a water bath at 40°C to a transparent solution to obtain an oil phase for use;

[0064] Dissolve 0.1% carnosine and 27.2% water in a water bath at 40°C under stirring to form a transparent solution to obtain an aqueous phase for use;

[0065] Add the water phase to the oil phase, stir at 45°C in a water bath at a speed of 550 rpm for 35 minutes, and emulsify at high speed at 8000 rpm for 3 minutes to prepare a micron-level dispersion;

[0066] The micron-level dispersion is subjected to high-pressure homogenization treatment under the condition of a pressure of 1200 bar, and is circulate...

Embodiment 2

[0070] 10.0% kaempferol, 0.1% magnolol, 5.0% glycyrrhetinic acid, 0.1% azelaic acid, 1.0% tert-butyl p-methoxyphenol, 1.0% polyoxyethylene sorbitan fatty acid ester, 3.0% poly Glycerin fatty acid ester, 1.0% polyoxyethylene hydrogenated castor oil, 9.0% dipropylene glycol, 11.0% ethoxy diethylene glycol oleate, 10.0% ethoxy diethylene glycol, 5.0% glyceryl stearate, 3.0 % Caprylic acid / capric acid polyethylene glycol glyceride, 5.0% isopropyl palmitate, stirred and dissolved in a water bath at 45°C to a transparent solution to obtain an oil phase for use;

[0071] Dissolve 10.0% niacinamide and 25.8% water in a water bath at 45°C under stirring to form a transparent solution to obtain an aqueous phase for use;

[0072] Add the water phase to the oil phase, stir in a water bath at 45°C and stir at 550 rpm for 35 minutes, and emulsify at high speed at 10000 rpm for 1 minute to prepare a micron-level dispersion;

[0073] The micron-level dispersion is subjected to high-pressure homogen...

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Abstract

The invention provides an acne removal co-transporting nano-composition, a preparation method thereof and an application of the nano-composition, and belongs to the technical field of cosmetics. The acne removal co-transporting nano-composition comprises, in weight percent, 0.1%-10.0% of grease secretion restraining active matters, 0.1%-10.0% of anti-bacterial inflammation active matters, 0.1-5% of anti-allergy agents, 0.1%-10.0% of acne mark weakening active matters, 0.1%-10.0% of cutin desquamation active matters, 5.0%-40.0% of emulsifying agents, 5.0%-30.0% of co-emulsifiers, 5.0%-30.0% ofcompound lipid, 0.1%-5.0% of stabilizers and the rest water. According to the acne removal co-transporting nano-composition, various acne removal active matters are loaded in the nano-composition, acne removal active components are co-transported in a multi-component and multiple target point manner, and the nano-composition has the functions of repairing damaged skins, weakening acne marks and acne scars, rebuilding skin barriers and the like.

Description

Technical field [0001] The invention relates to the technical field of cosmetics, in particular to a nanocomposite for acne removal co-delivery and a preparation method thereof. Background technique [0002] "Acne" is the common name of acne, also called "acne", "acne" or "acne". It is a skin disease caused by blocked and inflamed hair follicles and sebaceous ducts. The main clinical manifestations of acne (acne) are blackheads, whiteheads, inflammatory papules, pustules, nodules, and cysts, which are prone to pigmentation, large pores and even scar-like damage. The cause of acne is usually nothing more than diet, hormonal imbalance, stress or heredity, or excessive secretion of male hormones, excessive oil secretion, bacterial infection, cross infection, pathogenic microorganisms (Propionibacterium acnes), immune antibodies , Skin allergies, improper diet, gastrointestinal disorders such as indigestion or constipation, or improper skin care. But no matter what the reason, it c...

Claims

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Application Information

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IPC IPC(8): A61K8/67A61K8/63A61K8/49A61K8/368A61K8/34A61Q19/00A61Q19/08A61Q19/02A61Q17/00A61P17/10A61P37/08A61P29/00A61P31/02A61P31/04
CPCA61K8/347A61K8/368A61K8/498A61K8/63A61K8/675A61P17/10A61P29/00A61P31/02A61P31/04A61P37/08A61Q17/005A61Q19/00A61Q19/008A61Q19/02A61Q19/08
Inventor 刘卫郭赛红吴培诚陈家铃洪延涵闻庆
Owner WUHAN BEST CARRIER NANO TECH
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