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Novel electrochemical sensor detection technique for nonenzymatic glucose

A sensor and glucose technology, applied in the field of glucose detection, can solve the problems of glucose detection results, electrochemical sensor interference, easy inactivation, etc.

Inactive Publication Date: 2018-11-13
NORTHEAST NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Amperometric glucose biosensor detection methods can be divided into enzymatic and non-enzymatic methods. For immobilized glucose oxidase sensors, due to the inherent properties of the enzyme itself, there are unstable and easily inactivated substances in the immobilization process. Shortcomings, and this type of electrochemical sensor is easily interfered by factors such as temperature and chemical environment, which will affect the detection results of glucose

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] Take 7.32g of sodium vanadate in 38mL of water, and another 8.22g of sodium molybdate in 12mL of water, mix the two, dissolve 4.5mL of phosphoric acid solution with a mass concentration of 85% in water and dilute, and dilute the diluted phosphoric acid solution drop by drop Add it to the previous mixture, and stir for 1 h at a water bath temperature of 95°C. After cooling, transfer the solution to 150mL saturated sodium chloride solution to obtain a brown precipitate, then recrystallize twice in 20mL 0.25M sulfuric acid solution, suction filter, and dry to obtain a solid polyacid catalyst.

Embodiment 2

[0029] 0.15M ZrOCl 2 and 20mM SBS surfactant were respectively dissolved in a mixed solution of water and ethanol with a volume ratio of 1:1, heated in a water bath until completely dissolved, and then the ZrOCl 2 The aqueous solution was added dropwise to the SBS surfactant aqueous solution, and after being vigorously stirred for 20 minutes, it was loaded into a polytetrafluoroethylene autoclave, calcined at 450°C for 5 hours, and the obtained white solid was ground uniformly to obtain zirconium dioxide.

Embodiment 3

[0031] The glassy carbon electrode was successively dripped with 0.3 μm, 0.05 μm Al 2 o 3 The suspension was polished into a mirror surface on the polishing cloth, and then ultrasonically cleaned in dilute sodium hydroxide, dilute nitric acid, absolute ethanol, and secondary water in turn, until the glassy carbon electrode detected the peak-to-peak potential difference in the potassium ferricyanide standard solution to reach Standard value, dry the electrode with nitrogen for later use. Modified electrode preparation process: first, the bare electrode is used as the working electrode, the platinum wire is used as the auxiliary electrode, and silver / silver chloride (Ag / AgCl) is used as the reference electrode, and the PDDA solution is adsorbed on the bare electrode by electrodeposition. Then 5μL 4mg / ml ZrO 2 The NPs solution was drip-coated on the electrode surface and dried to obtain ZrO 2 / GCE. Finally, in 5mM NPVMo solution, use 0.1M sulfuric acid solution as electrolyte...

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Abstract

The invention relates to a nonenzymatic current type electrochemical sensor with good selectivity and high sensitivity, belongs to the field of electrochemical analysis and testing of nanometer material modified electrodes, and relates to a nonenzymatic glucose sensor technique. The nonenzymatic current type electrochemical sensor has the advantages that the glucose can be sensitively, accuratelyand quickly measured; the specificity is excellent, and the stability is good; the actual sample detection result is consistent with the detection result of a glucometer; the operation is simple in the whole process, and the green and environment-friendly effects are realized.

Description

technical field [0001] The invention relates to the technical fields of preparation of nanocomposite materials and research on electrocatalytic activity, preparation of non-enzymatic current type electrochemical sensors and glucose detection, specifically relates to a new multi-acid catalyst and metal oxide nanomaterials, and also relates to the electrocatalyst Application of chemical sensors in glucose detection. [0002] claims [0003] 1. A transition metal nanocomposite material prepared under mild conditions, using this as a sensor substrate to prepare a glucose non-enzyme electrochemical sensor, which can detect glucose in serum with high sensitivity and high selectivity. [0004] 2, the polyacid compound that adopts is preferably: (NH 4 ) 5 h 6 PV 8 Mo 4 o 40 technical background [0005] Diabetes mellitus, a chronic metabolic disease characterized by high blood sugar, is one of the most common and deadly diseases in people's lives. According to the latest re...

Claims

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Application Information

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IPC IPC(8): G01N27/327G01N27/30G01N27/38
CPCG01N27/308G01N27/3278G01N27/38
Inventor 王胜天李玲
Owner NORTHEAST NORMAL UNIVERSITY
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