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Preparation method of polysaccharide-silk fibroin composite anticoagulant biomaterial

A technology of silk fibroin and biomaterials, which is applied in anticoagulant treatment, types of packaging items, special packaging items, etc., can solve the problems of complex process, solvent toxicity, poor controllability, etc., and achieve low raw material cost and high process efficiency Simple, readily available ingredients

Inactive Publication Date: 2018-11-16
赵延延
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the common weaknesses of these surface modification methods, such as solvent toxicity, complicated process, and poor controllability, not only the designability of the material surface is greatly limited, but also the modification of medical devices with complex geometric shapes cannot be realized. Meet the needs of the rapid development of medical devices

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] (1) Mix 20 parts of corn starch, 10 parts of gum arabic, 2 parts of mannan, 10 parts of polyvinyl carbonate, 2 parts of polycarbonate, 8 parts of silk fibroin, tetraisopropyl bis (dilauryl phosphite ) 2 parts of titanate were added into an ultrasonic oscillator for dispersion and coupling, and the obtained solution was sieved and sorted for later use, wherein the ultrasonic power was 250KW, ultrasonic oscillation was 30min, and the sieve aperture was 2000 mesh;

[0025] (2) Add the solution of step (1) into the vacuum reactor, heat it to 50°C and then add 2 parts of polydimethylsilane, 2 parts of triethyl phosphate, 1 part of ethambutol, methylsulfonate 3 parts of acid, then the temperature rises to 180-185°C again, vacuumize, the vacuum pressure is 5*10 -8 Pa, continue to react for 2h, after the reaction, the air pressure in the furnace returns to normal pressure, and the reactant is kept warm for standby;

[0026] (3) Inject the reaction solution of step (2) into the...

Embodiment 2

[0032] (1) Mix 22 parts of corn starch, 13 parts of gum arabic, 4 parts of mannan, 12 parts of polyvinyl carbonate, 3 parts of polycarbonate, 9 parts of silk fibroin, bis(dioctylpyrophosphoryl) oxygen Add 3 parts of titanium acetate to an ultrasonic oscillator for dispersion and coupling, and the obtained solution is sieved and sorted for later use, wherein the ultrasonic power is 250KW, ultrasonic oscillation is 30min, and the sieve aperture is 2000 mesh;

[0033] (2) Add the solution of step (1) into the vacuum reactor, heat to 50°C and then add 3 parts of polydimethylsilane, 3 parts of triethyl phosphate, 1 part of ethambutol, methylsulfonate 4 parts of acid, then the temperature rises to 180-185°C again, vacuumize, the vacuum pressure is 5*10 -8 Pa, continue to react for 3 hours, after the reaction, the air pressure in the furnace returns to normal pressure, and the reactant is kept warm for standby;

[0034](3) Inject the reaction solution of step (2) into the injection ...

Embodiment 3

[0040] (1) Mix 24 parts of corn starch, 14 parts of gum arabic, 7 parts of mannan, 16 parts of polyvinyl carbonate, 6 parts of polycarbonate, 9 parts of silk fibroin, and isopropyltri(isostearyl)titanium Add 4 parts of acid ester to an ultrasonic oscillator for dispersion and coupling, and the obtained solution is sieved and sorted for later use, wherein the ultrasonic power is 250KW, ultrasonic oscillation is 30min, and the sieve aperture is 2000 mesh;

[0041] (2) Add the solution of step (1) into the vacuum reactor, heat it to 50°C and then add 5 parts of polydimethylsilane, 4 parts of triethyl phosphate, 2 parts of ethambutol, methylsulfonate 5 parts of acid, then the temperature rises to 180-185°C again, vacuumize, the vacuum pressure is 5*10 -8 Pa, continue to react for 4h, after the reaction, the air pressure in the furnace returns to normal pressure, and the reactant is kept warm for standby;

[0042] (3) Inject the reaction solution of step (2) into the injection mol...

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PUM

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Abstract

The invention discloses a preparation method of a polysaccharide-silk fibroin composite anticoagulant biomaterial. According to the process, the polysaccharide-silk fibroin composite anticoagulant biomaterial is prepared from raw materials of corn starch, Arabic gum, mannan, polyethylene carbonate, polycarbonate, silk fibroin, polydimethylsilane, triethyl phosphate, ethambutol, methane sulfonic acid and the like respectively by the steps of ultrasonic oscillation dispersion, sieving sorting, vacuum heating reaction, injection molding die-pressing, cooling fixing, ultrasonic cleaning, absorption equilibrium of an aqueous solution of positive and negative polyelectrolytes, washing and air-drying, nitrogen protection curing and the like. The prepared polysaccharide-silk fibroin composite anticoagulant biomaterial is low in raw material cost, has obvious anticoagulation and antithrombotic activity, and is suitable for application in the aspect of various medical blood pipes and accessories.

Description

technical field [0001] The invention relates to the technical field of biological materials, in particular to a preparation method of a polysaccharide-silk fibroin composite anticoagulant biological material. Background technique [0002] The blood environment is one of the most important environments for the human body. Good blood compatibility materials can be widely used in various medical interventional devices in contact with blood, blood purification and dialysis devices, extracorporeal circulation devices and artificial lungs, artificial livers, artificial Various artificial organs such as the heart. has great clinical significance. However, most synthetic materials will non-specifically induce the adsorption of various proteins (including coagulation factors) when in contact with blood, induce the generation of thromboplastin through the intrinsic and extrinsic coagulation pathways, activate platelets, and finally lead to coagulation. Biomaterials with good anticoa...

Claims

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Application Information

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IPC IPC(8): A61L33/12A61L33/08A61L33/06A61L33/04A61L33/00
CPCA61L33/0011A61L33/04A61L33/068A61L33/08A61L33/128A61L2300/42C08L3/02C08L5/00C08L69/00C08L89/00C08L83/04
Inventor 赵延延
Owner 赵延延
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