lzq fluorescent probe simultaneously detects so 2 Derivatives and applications in hsa
A technology of fluorescent probes and derivatives, which is applied in the application field of LZQ fluorescent probes in the simultaneous detection of SO2 derivatives and HSA, can solve the problems of dual-channel simultaneous detection and sensing difficulties, and achieves high sensitivity, good selectivity, and high sensitivity. Combining simple effects
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Embodiment 1
[0044] A LZQ fluorescent probe simultaneously detects SO 2 Derivatives and applications of HSA, the structure of the LZQ fluorescent probe is as follows:
[0045] , the LZQ fluorescent probe can simultaneously detect SO 2 Derivatives and HSA.
[0046] The preparation method of described LZQ fluorescent probe, the steps are as follows:
[0047] 2-Acetonitrile benzothiazole (209 mg, 1.2 mmol) was dissolved in ethanol (10 mL), and cooled to 5 °C, 7-(diethylamino) salicylaldehyde (1-b) was added thereto, Then piperidine (0.05 mL) was added. The mixture was stirred at reflux temperature and the reaction was complete within 5 hours as checked by TLC. After cooling, the reaction system was poured into ice water (25 mL), resulting in a large amount of precipitate, and the crude product was filtered, washed with cold ethanol, and dried under vacuum. The crude product was purified by column chromatography using silica gel (100-200 mesh) and 10% ethyl acetate in petroleum ether to...
Embodiment 2
[0051] A LZQ fluorescent probe simultaneously detects SO 2 Derivatives and applications of HSA, the structure of the LZQ fluorescent probe is as follows:
[0052] , the LZQ fluorescent probe can simultaneously detect SO 2 Derivatives and HSA.
[0053] The preparation method of described LZQ fluorescent probe, the steps are as follows:
[0054] (1) Mix 4-(diethylamino)salicylaldehyde (289.86 mg, 1.5 mmol), diethyl malonate (240.2 mg, 1.5 mmol) and ethanol, and add 11.7 mL of piperidine (1 mmol) after mixing and stirred under reflux conditions for 6 h, removed ethanol with a rotary evaporator, then added concentrated HCl and glacial acetic acid, stirred at reflux temperature for 6 h, after the reaction was completed, the solution was cooled to room temperature, and poured into ice water, dropwise The NaOH solution adjusted the pH to 5 to form a precipitate. After stirring for 1 hour, the mixture was filtered, washed with water, and dried to obtain 7-diethylaminocoumarin;
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Embodiment 3
[0058] A LZQ fluorescent probe simultaneously detects SO 2 Derivatives and applications of HSA, the structure of the LZQ fluorescent probe is as follows:
[0059] , the LZQ fluorescent probe can simultaneously detect SO 2 Derivatives and HSA.
[0060] The preparation method of described LZQ fluorescent probe, the steps are as follows:
[0061] (1) Mix 4-(diethylamino) salicylaldehyde (289.86 mg, 1.5 mmol), diethyl malonate (240.2 mg, 1.5 mmol) and ethanol, add 17.5 mL of piperidine after mixing, and Stir at low temperature for 10 h, remove ethanol with a rotary evaporator, then add concentrated HCl and glacial acetic acid, stir at reflux temperature for 10 h, after the reaction is completed, cool the solution to room temperature, pour it into ice water, and add NaOH solution dropwise to adjust the pH To 5, a precipitate was formed, and after stirring for 1 hour, the mixture was filtered, washed with water, and dried to obtain 7-diethylaminocoumarin;
[0062] (2) in N 2 ...
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