Dynamic crosslinking double-network water gel as well as preparation method and application thereof

A dynamic cross-linking and double-network technology, applied in the fields of pharmaceutical formulations, medical science, prostheses, etc., can solve the problems of cytotoxicity, low mechanical, thermal, chemical stability, rejection, etc., and achieve simple preparation methods and excellent mechanics performance effect

Active Publication Date: 2018-11-23
UNIVERSITY OF CHINESE ACADEMY OF SCIENCES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The disadvantages are: low mechanical, thermal and chemical stability, possible rejection and risk of disease transm

Method used

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  • Dynamic crosslinking double-network water gel as well as preparation method and application thereof
  • Dynamic crosslinking double-network water gel as well as preparation method and application thereof
  • Dynamic crosslinking double-network water gel as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Embodiment 1, preparation of hydroxyethyl chitosan / calcium alginate dynamic cross-linked double network hydrogel

[0050]Prepare mixed solution 1 of 20mg / ml hydroxyethyl chitosan and 20mg / ml calcium chloride, prepare mixed solution 2 of 20mg / ml CHO-PEG-CHO and 20mg / ml sodium alginate, mix mixed solution 1 and mixed solution 2 Mix and stir at room temperature, mix and inject into a special mold to obtain a dynamic cross-linked double network hydrogel, which is released from the mold after 5 minutes to obtain a regular columnar body, which is the dynamic cross-linked double network hydrogel of hydroxyethyl chitosan / calcium alginate. The network hydrogel is subjected to a mechanical compression test on a universal testing machine, and the compressive stress is 0.12MPa, and the fracture deformation rate is 52%.

[0051] Prepare a 20mg / ml hydroxyethyl chitosan solution and a 20mg / ml CHO-PEG-CHO solution, mix them and inject them into the mold, and release them from the mold ...

Embodiment 2

[0059] Example 2, Preparation of Hydroxyethyl Chitosan / Calcium Alginate Dynamically Crosslinked Double Network Hydrogel

[0060] Prepare mixed solution 1 of 40mg / ml hydroxyethyl chitosan and 20mg / ml calcium chloride, prepare mixed solution 2 of 40mg / ml CHO-PEO-CHO and 20mg / ml sodium alginate, mix mixed solution 1 and mixed solution 2 Mix and stir at room temperature, mix and inject into a special mold to obtain a dynamic cross-linked double network hydrogel, demould from the mold after 5 minutes to obtain a regular columnar body, perform a mechanical compression test on a universal testing machine, and obtain a compressive stress of 0.23MPa, The fracture deformation rate was 54%.

Embodiment 3

[0061] Example 3, Preparation of polyvinylamine / iron polyacrylate dynamically cross-linked double network hydrogel

[0062] Prepare a mixed solution 1 of 20mg / ml polyvinylamine and 20mg / ml ferric chloride, prepare a mixed solution 2 of 20mg / ml CHO-PEG-CHO and 20mg / ml polyacrylic acid, mix the mixed solution 1 and the mixed solution 2 and let it cool at room temperature Stir, mix and pour into a special mold to obtain a dynamic cross-linked double network hydrogel. After 5 minutes, it is demolded from the mold to obtain a regular columnar body. The mechanical compression test is carried out on a universal testing machine, and the compressive stress is 0.08MPa, and the fracture deformation rate is 0.08MPa. 75%.

[0063] Prepare a 20mg / ml polyvinylamine solution and a 20mg / ml CHO-PEG-CHO solution, mix them and inject them into the mold, release them from the mold after 5 minutes to obtain a regular columnar body, perform a mechanical compression test on a universal testing machin...

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Abstract

The invention discloses dynamic crosslinking double-network water gel as well as a preparation method and application thereof. The dynamic crosslinking double-network water gel is formed by a main network and a sub network through the penetration insertion winding and tying in a aqueous medium; the main network is dynamic covalent bond crosslinked polymers; the sub network is ion bond crosslinkedpolymers; the covalent bond crosslinked polymers are formed by polymers A and polymers B through covalent bond crosslinking; the ion bond crosslinked polymers are formed by polymers C and ion compounds through ion bonds. The preparation method is simple; the in-situ injection shaping can be realized; the fast in-situ formation of the water gel after the compounding of several kinds of ingredientsof the composite gel can be performed; the operation can be performed at the normal temperature. The water gel prepared by the method can fast form the required shape in required positions; the modelpreparation in advance is not needed; the speed is high; convenience is realized; meanwhile, the excellent mechanical performance of the water gel is considered, so that wide application prospects arerealized in the tissue restoration.

Description

technical field [0001] The invention relates to a double-network hydrogel, in particular to a dynamic cross-linked double-network hydrogel and its preparation method and application. Background technique [0002] Hydrogel is a polymer material with a network cross-linked three-dimensional structure. It uses water as the dispersion medium. The advantage of hydrogel is that it has a very high water content, which is similar to human tissue, and can be modified to obtain a good tissue phase. Capacitance, degradability and low cytotoxicity make it widely used in drug delivery and tissue repair. [0003] Commonly used hydrogel materials can be divided into natural polymers and synthetic polymers. Among them, natural polymer materials include proteins: collagen, silk protein, fibrin, etc.; polysaccharides: chitosan and its derivatives, hyaluronidase, alginic acid, starch-based materials, cellulose, dextran, etc. Their advantages are: low toxicity, biodegradability, relatively lo...

Claims

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Application Information

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IPC IPC(8): C08L5/08C08L5/04C08L71/02C08L79/02C08L33/02C08L29/04C08K3/16C08J3/24C08J3/075A61L27/26A61L27/52
CPCA61L27/26A61L27/52A61L2400/06A61L2430/06C08J3/075C08J3/246C08J2305/04C08J2305/08C08J2329/04C08J2333/02C08J2371/02C08J2379/02C08J2405/04C08K2003/162C08K2003/166C08L5/04C08L5/08C08L29/04C08L33/02C08L71/02C08L79/02C08L2203/02C08L2205/02C08L2205/03C08L2205/04C08L2312/00C08K3/16
Inventor 闫衍屈小中杨振忠杨迪李梦楠
Owner UNIVERSITY OF CHINESE ACADEMY OF SCIENCES
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