Dynamic crosslinking double-network water gel as well as preparation method and application thereof

Abstract

The invention discloses dynamic crosslinking double-network water gel as well as a preparation method and application thereof. The dynamic crosslinking double-network water gel is formed by a main network and a sub network through the penetration insertion winding and tying in a aqueous medium; the main network is dynamic covalent bond crosslinked polymers; the sub network is ion bond crosslinkedpolymers; the covalent bond crosslinked polymers are formed by polymers A and polymers B through covalent bond crosslinking; the ion bond crosslinked polymers are formed by polymers C and ion compounds through ion bonds. The preparation method is simple; the in-situ injection shaping can be realized; the fast in-situ formation of the water gel after the compounding of several kinds of ingredientsof the composite gel can be performed; the operation can be performed at the normal temperature. The water gel prepared by the method can fast form the required shape in required positions; the modelpreparation in advance is not needed; the speed is high; convenience is realized; meanwhile, the excellent mechanical performance of the water gel is considered, so that wide application prospects arerealized in the tissue restoration.

Description

technical field [0001] The invention relates to a double-network hydrogel, in particular to a dynamic cross-linked double-network hydrogel and its preparation method and application. Background technique [0002] Hydrogel is a polymer material with a network cross-linked three-dimensional structure. It uses water as the dispersion medium. The advantage of hydrogel is that it has a very high water content, which is similar to human tissue, and can be modified to obtain a good tissue phase. Capacitance, degradability and low cytotoxicity make it widely used in drug delivery and tissue repair. [0003] Commonly used hydrogel materials can be divided into natural polymers and synthetic polymers. Among them, natural polymer materials include proteins: collagen, silk protein, fibrin, etc.; polysaccharides: chitosan and its derivatives, hyaluronidase, alginic acid, starch-based materials, cellulose, dextran, etc. Their advantages are: low toxicity, biodegradability, relatively lo...

AI Technical Summary

Problems solved by technology

The disadvantages are: low mechanical, thermal and chemical stability, possible rejection and risk of disease transmission

However, artificially synthesized polymers face a series of problems such as cytotoxicity and biocompatibility.

Images