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A drug-coated balloon and its preparation method and application

A drug coating and balloon technology, which is applied in the field of biomedicine, can solve the problems of single drug loading, no coating technology, inability to achieve anticoagulation and antiproliferative endothelial growth at the same time, and achieve broad application prospects, Improves blood flushing and prolongs residence time

Active Publication Date: 2021-09-28
NANJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Existing studies mainly focus on coating the balloon surface with simple drugs (such as paclitaxel) or using nanomaterials to wrap anti-proliferative drugs (such as paclitaxel). It will be washed and lost by the blood flow in 20-30 minutes, and the latter is difficult to be coated on the surface of the polymer-based balloon, and a suitable coating technology that can be used for production has not yet been formed, and the type of drug loading is single, and it is impossible to simultaneously Achieve anticoagulation, anti-proliferation and promote endothelial growth

Method used

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  • A drug-coated balloon and its preparation method and application
  • A drug-coated balloon and its preparation method and application
  • A drug-coated balloon and its preparation method and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] A method for preparing a drug-coated balloon, comprising the steps of:

[0032] 1) Preparation of mesoporous-macroporous micro-nano tubular motors

[0033] Such as figure 1 Shown: take 10g tetraethyl orthosilicate and 74.8μL concentrated H 2 SO 4 Dissolved in 5.5g H 2 The first solution was obtained in O and 9 g ethanol; 2.83 g P123 was dissolved in 27 g ethanol and 5.55 g H 2 0 obtains the second solution; the first solution and the second solution are mixed uniformly and suction filtered into the polycarbonate template; the polycarbonate template after the suction filtration is soaked in the above-mentioned solution subsequently, keeps 8 days; The magnesium powder solution of 50nm-10μm is suction filtered to the polycarbonate template, dissolves the polycarbonate template, and releases to obtain the mesoporous-macroporous micro-nano tubular motor; the transmission electron microscope image of the mesoporous-macroporous micro-nano tubular motor is as figure 2 As ...

Embodiment 2

[0038] A method for preparing a drug-coated balloon, comprising the steps of:

[0039] 1) Preparation of mesoporous-macroporous micro-nano spherical motors

[0040] Take 1×1cm -2The size of the polymer film, the magnesium powder is evenly dispersed on the surface of the polymer film and placed in 10ml50mg·ml -1 In the dopamine Tris-HCl buffer solution, let it stand for 24 hours in the dark. After the reaction, wash and dry to obtain polydopamine-magnesium powder-polymer film; disperse 0.15ml hydrazine hydrate and 9.6μl tetraethyl orthosilicate in 30ml of water and stirred for 10 minutes to obtain a dispersion, polydopamine-magnesium powder-polymer film was placed in the dispersion and allowed to stand at 37°C for 5 hours; 2.4ml of 25% cetyltrimethyl Ammonium bromide, 0.18g triethylamine, 1.6ml cyclohexane, and 0.4ml tetraethylorthosilicate were mixed and stirred for 10 minutes, and left to stand at 37°C for 5 hours; the polymer film was removed with an organic solvent to rel...

Embodiment 3

[0045] Step 1) and step 2) are the same as step 1) and step 2) in Example 2 to prepare a mesoporous-macroporous micro-nano spherical motor loaded with growth factors, anti-tissue hyperplasia drugs and anticoagulant drugs. The mesoporous-macroporous micro-nano spherical motors of factors, anti-tissue hyperplasia drugs and anticoagulant drugs were evenly spin-coated on the bare balloon, then dried, and the balloon was taken out and washed three times with water and ethanol respectively to obtain the mesoporous-macroporous micro-nano spherical motor. Nanospherical motor drug-coated balloons, such as Figure 7 Shown: A is a bare balloon, B is a mesoporous-macroporous micro-nano spherical motor drug-coated balloon, and the surface of the mesoporous-macroporous micro-nano spherical motor drug-coated balloon is evenly coated with a layer of growth Mesoporous-macroporous micro-nano spherical motors for anti-proliferative and anticoagulant drugs.

[0046] The thickness of the drug coa...

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Abstract

The invention belongs to the field of biomedicine, and in particular relates to a novel drug-coated balloon and its preparation method and application. The new drug-coated balloon includes a balloon body and a drug coating covering the surface of the balloon body, the drug coating contains active drugs and carriers, and the active drugs are growth factors, anti-tissue proliferation drugs and anti-inflammatory drugs. A coagulant drug, the carrier is a mesoporous-macroporous micro-nanomotor. The novel drug-coated balloon prepared by the method avoids the disadvantages that the drug-coated drug on the traditional balloon has a single type of drug and is easily washed out by blood. Utilizing the self-driven characteristics of micro-nano motors, anti-proliferation drugs and anticoagulant drugs are loaded into mesoporous-macroporous micro-nano motors, which can stay in the vascular blockage site for a long time, improve drug utilization efficiency, and have broad application potential. application prospects in the medical field.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a drug-coated balloon and its preparation method and application. Background technique [0002] Since Gruntzing successfully developed percutaneous coronary artery balloon dilation technology in 1977, more than 2 million patients with coronary heart disease worldwide need percutaneous coronary intervention (PCI) every year. PCI has become the most important revascularization strategy for coronary heart disease . However, in-stent restenosis has always been one of the main factors affecting the long-term efficacy. The incidence of restenosis in simple percutaneous transluminal coronary angioplasty is as high as 30-60%. In the era of bare metal stents (BMS), the incidence of restenosis is more than 30%. The incidence of stenosis is reduced to about 5-10%, but the problem of in-stent restenosis has not been fundamentally solved. How to deal with in-stent restenosis has beco...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L29/16A61L29/08A61M25/10
CPCA61L29/08A61L29/16A61L2300/252A61L2300/414A61L2300/602A61M25/1029A61M2025/1031A61M2025/105A61M2205/0238
Inventor 毛春初美琳万密密邵水斌牛倩
Owner NANJING NORMAL UNIVERSITY