Selenium-zinc-calcium compound chewable tablets, and preparation method and applications thereof

A technology of chewable tablets and zinc-calcium, which is applied in the field of selenium-zinc-calcium chewable tablets and its preparation, can solve the problems of selenium deficiency onset hidden and difficult to be found, etc., to prevent human cell damage, easy to carry and store, Ease of consumption

Inactive Publication Date: 2018-12-07
济源希健生物医药科技发展有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the onset of selenium deficiency in the human body is very hidden and does not show any specific symptoms, so it is difficult to be detected clinically

Method used

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  • Selenium-zinc-calcium compound chewable tablets, and preparation method and applications thereof
  • Selenium-zinc-calcium compound chewable tablets, and preparation method and applications thereof
  • Selenium-zinc-calcium compound chewable tablets, and preparation method and applications thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Grind L-selenium-methylselenocysteine, zinc gluconate, calcium carbonate, powdered sugar, xylitol, mannitol, and magnesium stearate in advance, and pass through a 60-mesh sieve; Base selenocysteine, zinc gluconate, calcium carbonate are mixed according to the mass ratio of 0.001:0.1:5, then add the powdered sugar that mass ratio is 30:5:5: xylitol: mannitol mixes, then add The syrup with a mass ratio of 0.3 is stirred evenly to prepare a soft material (the degree to which the prepared soft material can be held tightly with hands can be formed into agglomerates, and can be cracked by pressing with fingers); the prepared soft material is granulated through a 14-mesh sieve, Then dry it in a vacuum oven at 40°C, control the moisture content at 2%, and then pass through a 18-mesh sieve to remove broken parts. The prepared granules are added with magnesium stearate at a mass ratio of 0.3, fully mixed, and then compressed into chewable tablets on a tablet machine.

Embodiment 2

[0023] Grind L-selenium-methylselenocysteine, zinc gluconate, calcium carbonate, powdered sugar, xylitol, mannitol, and magnesium stearate in advance, and pass through a 60-mesh sieve; Base selenocysteine, zinc gluconate, calcium carbonate are mixed according to the mass ratio of 0.01:1:20, then add the powdered sugar that mass ratio is 80:10:10: xylitol: mannitol mixes, then add The syrup with a mass ratio of 1.5 is stirred evenly to prepare a soft material (the degree to which the prepared soft material can be held tightly with hands can form agglomerates, and can be cracked by pressing with fingers); the prepared soft material is granulated through a 20-mesh sieve, Then dry in a vacuum drying oven at 65°C, the moisture content is controlled at 8%, and then pass through a 24-mesh sieve to remove broken parts. The prepared granules are added with magnesium stearate at a mass ratio of 1, fully mixed, and then compressed into chewable tablets on a tablet machine.

Embodiment 3

[0025] Grind L-selenium-methylselenocysteine, zinc gluconate, calcium carbonate, powdered sugar, xylitol, mannitol, and magnesium stearate in advance, and pass through a 60-mesh sieve; Base selenocysteine, zinc gluconate, calcium carbonate are mixed according to the mass ratio of 0.015:0.5:10, then add the powdered sugar that mass ratio is 50:7.5:7.5: xylitol: mannitol mixes, then add The syrup with a mass ratio of 1.0 is evenly prepared into a soft material (the degree to which the prepared soft material can be held tightly by hand can be formed into agglomerates, and can be cracked by pressing with fingers); the prepared soft material is granulated through a 18-mesh sieve, Then dry in a vacuum oven at 50°C, the moisture content is controlled at 6%, and then pass through a 20-mesh sieve to remove broken parts. The prepared granules are added with magnesium stearate at a mass ratio of 0.6, fully mixed, and then compressed into chewable tablets on a tablet machine.

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Abstract

The present invention discloses selenium-zinc-calcium compound chewable tablets, and a preparation method and applications thereof, and belongs to the field of functional foods. The chewable tablets comprise the following components: L-selenium-methyl selenocysteine, zinc gluconate, calcium carbonate, powdered sugar, xylitol, mannitol and magnesium stearate. The preparation method is as follows: taking the L-selenium-methyl selenocysteine, the zinc gluconate and the calcium carbonate as main functional ingredients; preparing other auxiliary materials according to a certain proportion; and performing the following process steps: raw material pretreatment, mixing, soft material preparation, granulation, drying, granule sieving and tabletting so as to obtain the selenium-zinc-calcium compoundchewable tablets. The chewable tablets are complete in shape, smooth and clear in appearance, moderate in hardness, delicious with slight sweetness and sourness, and convenient to eat; and the tablets are taken by chewing, so that active ingredients can directly scatter in the oral cavity and the stomach. The chewable tablets well keep the physiological activities of the L-selenium-methyl selenocysteine such as oxidation resistance.

Description

technical field [0001] The invention belongs to the technical field of functional foods, and in particular relates to a selenium-zinc-calcium compound chewable tablet, a preparation method and application thereof. Background technique [0002] Selenium is an essential trace element for human growth and development. In the human body, selenium is mainly involved in the formation of glutathione reductase, has direct and indirect antioxidant effects, and can protect the functions of the cardiovascular and cerebrovascular functions and the functions of the sensory system , Stimulate the secretion of immunoglobulin, relieve the toxic and side effects of certain heavy metal elements. However, the onset of selenium deficiency in the human body is very hidden and does not show any specific symptoms, so it is difficult to be found clinically. Especially for children, selenium deficiency can lead to growth retardation, decreased immunity and resistance, malabsorption of nutrients, he...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/16A23L33/175
CPCA23L33/16A23L33/175A23V2002/00A23V2200/30A23V2200/324A23V2250/1626A23V2250/1642A23V2250/1578
Inventor 姚一姚永强李金冯书晓范江伟姚品
Owner 济源希健生物医药科技发展有限公司
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