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Gemini surfactant containing selenium atom in space group and preparation method thereof

A technology of gemini surface and active agent, which is applied in the field of gemini surfactant containing selenium atom in the spacer and its preparation, and achieves the effects of short process, good compatibility and strong biodegradation performance.

Active Publication Date: 2018-12-07
JIANGNAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, gemini surfactants containing trace element selenium are rarely reported and need to be developed urgently

Method used

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  • Gemini surfactant containing selenium atom in space group and preparation method thereof
  • Gemini surfactant containing selenium atom in space group and preparation method thereof
  • Gemini surfactant containing selenium atom in space group and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0031] 5.2 g of 1,2-dibromoethane and 30 mL of acetonitrile were added to the flask, and heated to 90°C. After fully stirring, slowly add the acetonitrile solution containing 4.0g N,N-dimethyldodecyl tertiary amine through the constant pressure dropping funnel, control the pH of the system at 10.0 by sodium hydroxide, and continue to react at this temperature for 8 hours . The solvent was removed to obtain intermediate M in 89% yield. Weigh 3.9g of intermediate M, dissolve 0.6g of sodium selenide in 20mL of deionized water, heat to 60°C and stir for reaction for 12 hours. After removing the solvent, the gemini surfactant 12-2-Se-2-12 containing a single selenium atom in the spacer can be obtained by recrystallization with ether, and the yield reaches 90%.

Embodiment 2

[0033] Add 9.5 g of 1-bromo-3-chloropropane and 50 mL of acetonitrile into the flask, and heat to 75°C. After fully stirring, the acetonitrile solution containing 5.4g N, N-dimethyldodecylamidopropyl tertiary amine was slowly added through a constant pressure dropping funnel, and the pH of the system was controlled at 9.6 by potassium hydroxide, and continued at this temperature. The reaction was carried out for 12 hours. The solvent was removed to obtain intermediate M in a yield of 93%. Weigh 6.5g of intermediate M, dissolve 1.0g of disodium diselenide in 40mL of deionized water, heat to 70°C and stir for 18 hours. After removing the solvent, recrystallize with ether / ethyl acetate mixture solvent to obtain the gemini surfactant 12N-3-SeSe-3-12N containing diselenium in the spacer, and the yield reaches 91%.

Embodiment 3

[0035] 2.6 g of 1,4-dichlorobutane and 20 mL of acetonitrile were added to the flask, and heated to 100°C. After fully stirring, slowly add the acetonitrile solution containing 2.8g N,N-diethylhexadecyl tertiary amine through the constant pressure dropping funnel, control the pH of the system at 8.8 by potassium bicarbonate, and continue to react at this temperature for 12 hours . The solvent was removed to obtain intermediate M in 83% yield. Weigh 3.3g of intermediate M, dissolve 0.38g of sodium selenide in 30mL of deionized water, heat to 70°C and stir for reaction for 20 hours. After removing the solvent, the gemini surfactant 16-4-Se-4-16 containing monoselenium in the spacer can be obtained by recrystallization with acetone / ethyl acetate mixture solvent, and the yield reaches 86%.

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PUM

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Abstract

The invention discloses a gemini surfactant containing a selenium atom in a space group and a preparation method thereof. The preparation method includes the following steps: a step of intermediate preparation, namely a step of reacting long chain tertiary amines with dihaloalkanes to obtain an intermediate M; and a step of gemini surfactant preparation, namely a step of reacting the intermediateM with sodium selenide or disodium diselenide and purifying to obtain the gemini surfactant containing a selenium atom in the space group. The gemini surfactant containing a selenium atom in the spacegroup has the advantages of high surface activity, low critical micelle concentration, good compatibility and the like of a gemini surfactant and the sterilization, anti-inflammation and anti-oxidation functions of a selenium atom.

Description

technical field [0001] The invention belongs to the technical field of fine chemicals, and in particular relates to a gemini surfactant containing a selenium atom in a spacer and a preparation method thereof. Background technique [0002] Selenium (Se), one of the essential trace mineral nutrients for the human body, plays an important role in many key metabolic processes in the human body. It has been regarded as an important food source antioxidant, not only as a selenium enzyme or as The active ingredient of protein, scavenging free radicals, protecting cell membranes from oxidation, enhancing the body's immunity, and antagonizing the toxicity of mercury, arsenic, cadmium, and thallium, and having insulin-mimetic effects such as lowering blood sugar and regulating insulin-mediated metabolic processes . Therefore, how to use the nutrition of selenium to improve the quality of life of human beings has always been the goal pursued by people. [0003] Surfactant is an impor...

Claims

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Application Information

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IPC IPC(8): B01F17/18B01F17/00C09K23/18C09K23/00
CPCC09K23/00
Inventor 张永民陈志强顾清林李东炎
Owner JIANGNAN UNIV
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