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New synthesis method of orotic acid

An orotic acid and new method technology, applied in the direction of organic chemistry, can solve the problems of non-compliance with environmental protection requirements, use of dangerous reagents, and high cost of raw materials, and achieve the effects of avoiding by-products, less environmental pollution, and short process routes.

Inactive Publication Date: 2018-12-21
CHENGDU BAISHIXING SCI & TECH IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0012] In order to overcome the disadvantages of using dangerous reagents, high cost of raw materials, complex operation, many wastes, and failure to meet environmental protection requirements in the preparation of orotic acid in the above-mentioned prior art, the present invention provides an orotic acid capable of overcoming the existing technical drawbacks. A new method for the synthesis of clear acid

Method used

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  • New synthesis method of orotic acid
  • New synthesis method of orotic acid
  • New synthesis method of orotic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] S1: Add 300 kg of 10% industrial concentrated ammonia water to a 1000-liter reactor, turn on the circulating refrigerant, lower the temperature of the reaction liquid to about 0°C, and slowly drop 66 kg of 50% hydroxyacetonitrile solution into the reaction liquid while stirring; After the dropwise addition, keep the internal temperature at 0-10°C and continue to stir for 4 hours to stop the reaction; remove the freezing liquid, turn on the circulating water, turn on the vacuum, raise the temperature to 40-50°C, and remove the excess ammonia gas in the reaction system to obtain the reaction system a;

[0037] S2: Use concentrated hydrochloric acid to adjust the pH of the reaction system a to 5-6, add 180 kg of 25% sodium cyanate solution dropwise, and keep the pH of the system unchanged. After the addition, the temperature is raised to 80°C for 5 hours, and the reaction is completed by spotting. Obtain reaction system b;

[0038] S3: Pump 102 kg of 50% glyoxylic acid in...

Embodiment 2

[0041] S1: Add 320 kg of 10% industrial concentrated ammonia water to a 1000-liter reactor, turn on the circulating refrigeration liquid, lower the temperature of the reaction liquid to about 0°C, and slowly add 68 kg of fresh 50% hydroxyacetonitrile solution to the reaction liquid under stirring In the process, after the dropwise addition is completed, keep the internal temperature at 0-10°C and continue stirring for 4 hours, then stop the reaction. Remove the freezing liquid, turn on the circulating water, turn on the vacuum, raise the temperature to 40-50°C, and pump out the excess ammonia gas in the reaction system to obtain the reaction system a;

[0042] S2: Use concentrated hydrochloric acid to adjust the pH of the reaction system a to 5-6, add 190 kg of 25% sodium cyanate solution dropwise, keep the pH of the system constant while adding dropwise, raise the temperature to 80°C for 5 hours after the dropwise addition, and spot the plate for detection After the reaction ...

Embodiment 3

[0046]S1: Add 350 kg of 10% industrial concentrated ammonia water to a 1000-liter reactor, turn on the circulating refrigeration liquid, lower the temperature of the reaction liquid to about 0°C, slowly add 72 kg of 50% hydroxyacetonitrile solution to the reaction liquid dropwise under stirring, After the dropwise addition is completed, keep the internal temperature at 0-10°C and continue to stir the reaction for 4 hours, stop the reaction, remove the freezing liquid, turn on the circulating water, turn on the vacuum, raise the temperature to 40-50°C, pump out the excess ammonia gas in the reaction system, use the waste gas The absorption tower is sprayed and absorbed, and recovered for use;

[0047] S2: Use concentrated hydrochloric acid to adjust the pH of the reaction solution to 5-6, add 200 kg of 25% sodium cyanate solution dropwise, keep the pH of the system constant while adding dropwise, raise the temperature to 80°C for 5 hours after the addition, and spot the plate to...

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Abstract

The invention belongs to the field of organic chemistry and discloses a new synthesis method of orotic acid, comprising the following steps: S1: enabling glycolonitrile and ammonia wate to react, thusobtaining a reaction system a in which a product is aminoacetonitrile A; S2: enabling aminoacetonitrile A and cyanate to react, thus obtaining a reaction system b in which a product is cyanomethylurea B; S3: performing condensation-rearrangement on cyanomethylurea B and glyoxylic acid in an alkaline solution to obtain orotic acid I. The method has the advantages of safe operation, low cost, lesspollution from three wastes, total reaction yield of 80% or above, and easy industrialization.

Description

technical field [0001] The invention belongs to the field of organic chemistry, and in particular relates to a new method for synthesizing orotic acid. Background technique [0002] Orotic acid, also known as vitamin B13, is an effective precursor in the biosynthesis of pyrimidine-based nucleic acids in living organisms. It is an important pyrimidine derivative and plays a unique role in biology and medicinal chemistry. Orotic acid is widely used in medicine, food, health products, cosmetics and feed industries, and the current annual demand is more than 500 tons. [0003] The potentially valuable synthetic methods of orotic acid mainly include the following schemes. [0004] CH595351, DD144053, CN01126146 have reported the method for synthesizing orotic acid with maleic anhydride, urea and bromine as basic raw materials, and this method is still the mainstream orotic acid production method of manufacturers all over the world at present. The advantage of this reaction is t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D239/557
CPCC07D239/557
Inventor 石常青
Owner CHENGDU BAISHIXING SCI & TECH IND
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