New synthesis method of orotic acid
An orotic acid and new method technology, applied in the direction of organic chemistry, can solve the problems of non-compliance with environmental protection requirements, use of dangerous reagents, and high cost of raw materials, and achieve the effects of avoiding by-products, less environmental pollution, and short process routes.
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Embodiment 1
[0036] S1: Add 300 kg of 10% industrial concentrated ammonia water to a 1000-liter reactor, turn on the circulating refrigerant, lower the temperature of the reaction liquid to about 0°C, and slowly drop 66 kg of 50% hydroxyacetonitrile solution into the reaction liquid while stirring; After the dropwise addition, keep the internal temperature at 0-10°C and continue to stir for 4 hours to stop the reaction; remove the freezing liquid, turn on the circulating water, turn on the vacuum, raise the temperature to 40-50°C, and remove the excess ammonia gas in the reaction system to obtain the reaction system a;
[0037] S2: Use concentrated hydrochloric acid to adjust the pH of the reaction system a to 5-6, add 180 kg of 25% sodium cyanate solution dropwise, and keep the pH of the system unchanged. After the addition, the temperature is raised to 80°C for 5 hours, and the reaction is completed by spotting. Obtain reaction system b;
[0038] S3: Pump 102 kg of 50% glyoxylic acid in...
Embodiment 2
[0041] S1: Add 320 kg of 10% industrial concentrated ammonia water to a 1000-liter reactor, turn on the circulating refrigeration liquid, lower the temperature of the reaction liquid to about 0°C, and slowly add 68 kg of fresh 50% hydroxyacetonitrile solution to the reaction liquid under stirring In the process, after the dropwise addition is completed, keep the internal temperature at 0-10°C and continue stirring for 4 hours, then stop the reaction. Remove the freezing liquid, turn on the circulating water, turn on the vacuum, raise the temperature to 40-50°C, and pump out the excess ammonia gas in the reaction system to obtain the reaction system a;
[0042] S2: Use concentrated hydrochloric acid to adjust the pH of the reaction system a to 5-6, add 190 kg of 25% sodium cyanate solution dropwise, keep the pH of the system constant while adding dropwise, raise the temperature to 80°C for 5 hours after the dropwise addition, and spot the plate for detection After the reaction ...
Embodiment 3
[0046]S1: Add 350 kg of 10% industrial concentrated ammonia water to a 1000-liter reactor, turn on the circulating refrigeration liquid, lower the temperature of the reaction liquid to about 0°C, slowly add 72 kg of 50% hydroxyacetonitrile solution to the reaction liquid dropwise under stirring, After the dropwise addition is completed, keep the internal temperature at 0-10°C and continue to stir the reaction for 4 hours, stop the reaction, remove the freezing liquid, turn on the circulating water, turn on the vacuum, raise the temperature to 40-50°C, pump out the excess ammonia gas in the reaction system, use the waste gas The absorption tower is sprayed and absorbed, and recovered for use;
[0047] S2: Use concentrated hydrochloric acid to adjust the pH of the reaction solution to 5-6, add 200 kg of 25% sodium cyanate solution dropwise, keep the pH of the system constant while adding dropwise, raise the temperature to 80°C for 5 hours after the addition, and spot the plate to...
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