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A kind of biocompatible thermosensitive porous membrane material and preparation method thereof

A biocompatible, porous membrane technology, applied in the field of membrane materials, can solve the problems of poor biocompatibility, non-reusable, poor mechanical properties, etc., to achieve easy modification, good organic polymer compatibility, mechanical good performance

Active Publication Date: 2020-11-24
HARBIN INST OF TECH -WEIHAI INNOVATION PARK WEIHAI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Among the many temperature-sensitive materials prepared, the copolymer synthesized with N-isopro pylacrylamide as a monomer has become the most studied temperature-sensitive material, but it has poor biocompatibility, poor mechanical properties, poor stability and cannot be reused. etc., limiting its application

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] A biocompatible temperature-sensitive porous membrane material is prepared, comprising the following steps:

[0031] (1) Weigh 80 parts of polyisopropylacrylamide, 20 parts of polyacrylate, 5 parts of reinforcing agent glass fiber, 5 parts of chitin, 10 parts of polycaprolactone, porogen alginic acid according to the required parts by weight 10 parts of sodium; the molecular weight of polyacrylate is 50,000; the molecular weight of polyisopropylacrylamide is 10,000.

[0032] (2) The polyisopropylacrylamide and polycaprolactone weighed in the step (1) were added into the organic solvent I tetrahydrofuran, stirred and dissolved, and a mixture solution I with a mass concentration of 5% was prepared.

[0033] (3) The polyacrylate weighed in the step (1) was added into the organic solvent II acetone, stirred and dissolved, and a mixture solution II with a mass concentration of 5% was obtained.

[0034] (4) The mixture solution I prepared in step (2) and the mixture solution...

Embodiment 2

[0038] A biocompatible temperature-sensitive porous membrane material is prepared, comprising the following steps:

[0039] (1) Weigh 100 parts of polyisopropylacrylamide, 40 parts of polyacrylate, 20 parts of reinforcing agent silicon nitride whisker, 10 parts of chitin, 20 parts of polycaprolactone, porogen 40 parts of sucrose; the molecular weight of polyacrylate is 1 million; the molecular weight of polyisopropylacrylamide is 100,000.

[0040] (2) Add the polyisopropylacrylamide and polycaprolactone weighed in step (1) into the organic solvent I and stir to dissolve, so as to obtain a mixture solution I with a mass concentration of 30%; the organic solvent I is tetrahydrofuran, dichloromethane Any one of methane and petroleum ether.

[0041](3) Add the polyacrylate weighed in step (1) into the organic solvent II and stir to dissolve to obtain a mixture solution II with a mass concentration of 30%; the organic solvent II is any one of acetone, ethyl acetate, and methylene ...

Embodiment 3

[0046] A biocompatible temperature-sensitive porous membrane material is prepared, comprising the following steps:

[0047] (1) Weigh 85 parts of polyisopropylacrylamide, 25 parts of polyacrylate, 10 parts of reinforcing agent boron fiber, 6 parts of chitin, 12 parts of polycaprolactone, porogen chlorinated 15 parts of potassium; the molecular weight of polyacrylate is 50,000 to 1 million; the molecular weight of polyisopropylacrylamide is 10,000 to 100,000.

[0048] (2) The polyisopropylacrylamide and polycaprolactone weighed in the step (1) were added into the organic solvent I petroleum ether and stirred to dissolve to prepare a mixture solution I with a mass concentration of 10%.

[0049] (3) The polyacrylate weighed in the step (1) was added into the organic solvent II dichloromethane, stirred and dissolved, and a mixture solution II with a mass concentration of 10% was prepared.

[0050] (4) The mixture solution I prepared in step (2) and the mixture solution II prepare...

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Abstract

The invention relates to a biocompatible temperature-sensitive porous membrane material and a preparation method thereof, which solves the technical problems that the temperature-sensitive materials in the prior art have poor biocompatibility, poor mechanical properties, poor stability and cannot be reused. The invention provides a biocompatible temperature-sensitive porous membrane material, which consists of the following raw material components in parts by weight: 80-100 parts of polyisopropylacrylamide, 20-40 parts of polyacrylate, 5 parts of reinforcing agent -20 parts, 5-10 parts of chitin, 10-20 parts of polycaprolactone, 10-40 parts of porogen; meanwhile, a preparation method thereof is also provided. The invention is widely used in the field of membrane materials.

Description

technical field [0001] The invention relates to the field of membrane materials, in particular to a biocompatible temperature-sensitive porous membrane material and a preparation method thereof. Background technique [0002] Membrane materials have been widely used due to their own deformability and high toughness. With the research on smart materials, more and more smart materials have been applied in the field of membrane materials to prepare smart responsive membrane materials. Under the action of external stimuli, the microscopic molecular structure and molecular conformation of the intelligent responsive membrane material undergoes reversible changes, resulting in corresponding changes in some macroscopic properties of the material itself. These stimuli include pH, ionic strength, electricity, light, temperature, etc. And can be applied to the field of adsorption. [0003] In the biological field, the adsorption objects mainly include dyes, DNA, proteins and heavy meta...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08L33/24C08L33/04C08L5/08C08L67/04C08K7/14C08K7/10C08K7/06C08J5/18
CPCC08J5/18C08J2333/24C08J2405/08C08J2433/04C08K7/06C08K7/10C08K7/14
Inventor 张鹏刘康王传杰孙金平陈刚
Owner HARBIN INST OF TECH -WEIHAI INNOVATION PARK WEIHAI
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