Preparation method and application of rapid self-repairing gel with intelligent antibacterial function and long-acting biomolecule releasing function

Abstract

The invention provides a preparation method and application of a rapid self-repairing gel with an intelligent antibacterial function and a long-acting biomolecule releasing function. The preparation method comprises the following steps: uniformly mixing a disodium ethylene diamine tetraacetate solution with a ferric nitrate solution, then adding the obtained mixture into a hyaluronic acid solution, carrying out uniform mixing at room temperature, and then performing standing so as to obtain the self-healing gel. The generation of a hydrogel can be realized only through coordination action. Thepreparation method has the advantages of short reaction cycle, easy reaction conditions, high yield and no by-product, and can easily realize industrial production and effectively improve work efficiency. The self-repairing hydrogel can be used as a novel bioactive material for the regeneration of infected tissue and is also applicable as a gel patch for repairing inflammatory skin.

Description

technical field [0001] The invention relates to the fields of polymer material technology and biomedical materials, in particular to a preparation method and application of a fast self-repairing gel with intelligent antibacterial and long-term biomolecule release functions. Background technique [0002] Hydrogel is a kind of hydrophilic 3D network polymer with good biocompatibility, high water content and adjustable structural properties, thus widely used in the field of biomedicine. The gel can not only embed biologically active molecules (such as drugs, proteins, or antibodies) in the precursor solution to achieve target delivery, but also provide an environment similar to the extracellular matrix, where the porous structure allows the exchange of nutrients and metabolites. and cell migration, thereby promoting tissue regeneration. [0003] However, hydrogels are easily attacked by microorganisms during implantation, which may lead to infection and inflammatory responses ...

AI Technical Summary

Problems solved by technology

However, although the loading or grafting of antibacterial substances on hydrogels is beneficial to inhibit infection, there are still some negative problems in the continuous antibacterial process: such as toxic side effects on normal tissues, and the induction of bacteria with higher and higher drug resistance. , the effective time is very limited, the synthesis steps are complicated, etc., especially the adverse effects on mammalian cells are more obvious

However, multifunctional hydrogels with both on-demand antimicrobial properties to precisely inhibit bacterial growth and self-healing properties to ensure structural / functional integrity have not been discovered, which has become an urgent problem in biological tissue engineering.

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