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A kind of preparation method of manganese nicotinate

A technology of manganese nicotinate and nicotinic acid, applied in organic chemistry, animal husbandry, additional food elements, etc., can solve the problems of easy explosion or fire, relatively high requirements for reaction equipment, and low solubility of sodium chloride, etc. The effect of ruminant milk production, enhanced pig growth performance, and low equipment requirements

Active Publication Date: 2022-02-11
XINGJIA BIO ENG CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, this method cannot be applied to industry for the following reasons: (1) The reaction time is very long, the output in the unit body container is very low, and the production efficiency is extremely low; (2) Ethanol will dissolve a part of manganese nicotinate, and after the reaction is completed, the solid-liquid separation The yield is low; (3) The cost of reacting raw materials with pure ethanol is high, and at the same time, the requirements for reaction equipment are relatively high; (4) Ethanol has a low boiling point, is volatile, and has great safety hazards, which may cause explosion or fire; (5) The cost of ethanol recovery is high; (6) The solubility of the generated by-product sodium chloride in ethanol is not high, resulting in high impurity content in the product

Method used

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  • A kind of preparation method of manganese nicotinate
  • A kind of preparation method of manganese nicotinate
  • A kind of preparation method of manganese nicotinate

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] A preparation method of manganese nicotinate of the present invention is prepared through the following steps:

[0046] at 2m 3 Add 1 t of water to the reactor, add 100kg of nicotinic acid to the water, add 68kg of manganese sulfate monohydrate after heating to 65°C, cover the reactor and stir the reaction for 2.5h, and use sodium hydroxide solution to control the pH value to 5.5 throughout the process , after making it fully reacted, cooled, and centrifuged again, the solid product obtained after centrifugation was washed 3 times, and after flash drying, 123.5 kg of manganese nicotinate product was obtained.

[0047] The filtered mother liquor contains residual nicotinic acid and manganese nicotinate, which is recycled for use in the next batch of reactions; the number of cycles of recycling is 3 to 5 times.

[0048] After detection and analysis, the Mn in the product manganese nicotinate 2+ The mass content is 16.3%, the mass content of niacin ligand is 72.1%, n(C:H...

Embodiment 2

[0059] A preparation method of manganese nicotinate of the present invention is prepared through the following steps:

[0060] at 5m 3 Add 1.8t of water to the reaction kettle of 222kg of niacin, add 36L of isopropanol, heat up to 83°C, add 169kg of manganese sulfate monohydrate, stir for 0.5h, and use sodium hydroxide solution to control the pH value to 6.0, after making it fully reacted, cooling, and then filter-pressing, washing the product obtained after filter-pressing 3 times, drying at 105°C in a drying room and pulverizing to obtain 324.7kg of manganese nicotinate product.

[0061] The filtered mother liquor contains residual nicotinic acid and manganese nicotinate, which is recycled for use in the next batch of reactions; the number of cycles of recycling is 3 to 5 times.

[0062] After detection and analysis, the Mn in the product manganese nicotinate 2+ The mass content is 16.1%, the mass content of niacin ligand is 71.4%, n(C:H:N)≈6:6:1, the water loss rate of th...

Embodiment 3

[0073] A preparation method of manganese nicotinate of the present invention is prepared through the following steps:

[0074] at 5m 3 0.88t of water was added to the reaction kettle of 1, 220kg of niacin was added to the water, the temperature was raised to 30°C, 88L of isopropanol was added, 58kg of manganese oxide was added, the reaction was stirred for 1.5h, and the pH value was controlled to 6.5 with sodium hydroxide solution throughout the process. , after making it fully reacted, cooled, and centrifuged again, the product obtained after centrifugation was washed 3 times, and after flash drying, 271.0 kg of manganese nicotinate product was obtained.

[0075] The filtered mother liquor contains residual nicotinic acid and manganese nicotinate, which is recycled for use in the next batch of reactions; the number of cycles of recycling is 3 to 5 times.

[0076] After detection and analysis, the Mn in the product manganese nicotinate 2+ The mass content is 16.1%, the mass ...

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Abstract

The invention discloses a preparation method of manganese nicotinate, which comprises the following steps: adding nicotinic acid into water, then adding a manganese source to stir and react, controlling the pH value of the reaction system to be weakly acidic throughout the whole process, and cooling after complete reaction, solid-liquid After separation, the obtained solid product is washed and dried to obtain manganese nicotinate. The method is simple, the reaction time is short, the cost is low, the production efficiency is high, the equipment requirement is not high, and the yield of the product is high and the purity is high. The yield is as high as 95% or more in terms of manganese, and the product purity is as high as 98%. The invention also discloses the application of manganese nicotinate in animal feed. It is used in poultry feed, which has a good growth-promoting effect on poultry animals and improves the quality of carcass; it is used in pig feed, especially for the reproductive performance of breeding sows. It has been greatly improved; when used in aquatic feed, it has the effect of significantly improving growth performance and reducing mortality; when used in ruminant feed, it has the effect of increasing the milk production of ruminants and reducing the incidence of mastitis.

Description

technical field [0001] The invention belongs to the field of preparation of feed additives, in particular to a preparation method of manganese nicotinate and the application of manganese nicotinate in animal feed. Background technique [0002] Manganese is a component of arginase, prolinase, RNA polymerase, manganese-containing superoxide dismutase (Mn-SOD), pyruvate carboxylase, etc. It is also a component of many enzymes in the body such as phosphorylase, aldolase Activator of enzymes, transferases, and hydrolases. The absence of manganese in animals results in decreased feed intake, slower growth, lower feed utilization, bone abnormalities, ataxia, and reproductive dysfunction. [0003] Niacin is 3-picolinic acid, also known as nicotinic acid. It is a vitamin with the simplest structure and the most stable physical and chemical properties. It is an indispensable nutrient in humans and animals. The function of cell metabolism and expansion of blood vessels can promote th...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07D213/803C07D213/80A23K20/174A23K20/20A23K50/75A23K50/30A23K50/80A23K50/10
CPCA23K20/174A23K20/30A23K50/10A23K50/30A23K50/75A23K50/80C07D213/80C07D213/803
Inventor 向阳葵黄逸强邓敏彭红星夏飞辉苏军姚亚军张亚伟
Owner XINGJIA BIO ENG CO LTD
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