Auricularia auricular polysaccharide extraction method based on puffing treatment and preparation and application thereof

A black fungus polysaccharide and extraction method technology, applied in the field of black fungus polysaccharide extraction, can solve the problems of long extraction period, loss of active components, deterioration and the like, and achieve the effects of enhancing immunity and improving yield

Inactive Publication Date: 2019-01-25
INST OF MICROBIOLOGY HEILONGJIANG ACADEMY OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the scientific research institutes of colleges and universities and many enterprises have carried out relevant research on the extraction of black fungus by using modern science and technology, they are all in the laboratory scale and stage, mainly because the black fungus extraction system is extremely viscous under normal circumstances, and the separation of material and liquid is difficult. , the extraction efficiency is extremely low, and it is difficult to achieve large-scale production; the difficulty in separating the material and liquid leads to a long extraction cycle, the loss or deterioration of active ingredients, and the existing black fungus extract related products are not only of poor quality, but also seriously adulterated
[0004] At present, the research methods for extracting black fungus polysaccharides mainly include: hot water extraction method, alkali extraction method, enzymatic method, ultrasonic-assisted extraction method, microwave-assisted extraction method, etc. Facilitates the dissolution of active ingredients
Using hot water to extract polysaccharides is a simple and easy method with low cost but low yield and time-consuming
Alkaline extraction of polysaccharides can shorten the time and increase the yield, but if the pH is too high, the biological activity of polysaccharides is easily lost
Enzymatic extraction uses cellulase, pectinase and neutral protease combined with hot water extraction. Although the yield of black fungus polysaccharides is high, the molecular structure of black fungus polysaccharides is destroyed, and the molecular weight of the extracted polysaccharides is greatly changed. Small, thus affecting the efficacy of black fungus polysaccharides

Method used

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  • Auricularia auricular polysaccharide extraction method based on puffing treatment and preparation and application thereof
  • Auricularia auricular polysaccharide extraction method based on puffing treatment and preparation and application thereof
  • Auricularia auricular polysaccharide extraction method based on puffing treatment and preparation and application thereof

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Experimental program
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Effect test

Embodiment 1

[0029] Add 1000g of dried black fungus 16 mesh coarse powder, add 12% water and mix evenly, connect the external heating sleeve of the single-rod extrusion extruder, set the external heating time for 25min, set the high pressure of 3Mpa and the temperature of 210°C, and extrude Puffing treatment, then superfine crushing until the particle size is 100 mesh, take the superfine powder, add water 70 times according to the weight ratio, soak at room temperature for 30min, extract at 95°C for 1h, centrifuge the extract at 10,000rpm for 5min, and vacuum dry to obtain black Fungus polysaccharide 105.6g, crushed into fine powder, added appropriate amount of starch and dextrin, mixed well, made into granules, packed into hard capsules, and 1000 capsules were obtained.

Embodiment 2

[0031] Add 1000g of dry black fungus 32 mesh coarse powder, add 22% water and mix evenly, connect the external heating sleeve of the single-rod extrusion extruder, set the external heating time for 35min, set the high pressure of 8Mpa at a temperature of 190°C, and extrude Treatment, then superfine grinding to a particle size of 160 mesh, take the superfine powder, add water 50 times by weight, soak at room temperature for 90 minutes, extract at 100°C for 3 hours, centrifuge the extract at 3000rpm for 30 minutes, and vacuum dry to obtain black fungus 138.5g of polysaccharides, crushed into fine powder, added 7g of magnesium stearate, 300g of dextrin, supplemented with sucrose to the specified amount, mixed evenly, wet granulated, granulated after drying, and 1000g of granules were obtained.

Embodiment 3

[0033] Add 1000g of dry black fungus 24 mesh coarse powder, add 17% water and mix evenly, connect the external heating sleeve of the single-rod extrusion extruder, set the external heating time for 30min, set the high pressure of 6Mpa and the temperature of 200°C, and extrude Puffing treatment, then superfine crushing until the particle size is 120 mesh, take the superfine powder, add water 60 times according to the weight ratio, soak at room temperature for 60min, extract at 98°C, extract for 2h, centrifuge the extract at 4000rpm for 20min, and vacuum dry to obtain black 150.2 g of fungus polysaccharides, crushed into fine powder, added with 6.8 g of magnesium stearate, supplemented with sucrose to the specified amount, mixed evenly, made into granules, and pressed into tablets to obtain 1000 tablets of the preparation.

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Abstract

The invention provides an auricularia auricular polysaccharide extraction method based on puffing treatment and a preparation and application thereof, which belong to the technical field of biology. According to the auricularia auricular polysaccharide extraction method based on puffing treatment provided by the invention, auricularia auricular polysaccharide is obtained by dry auricularia auricular grinding, extrusion, extraction in water and centrifuging. The invention further provides the application of the auricularia auricular polysaccharide and the preparation thereof in the preparationof food, food for special medical purpose, health-care food and medicines in terms of oxidation resistance and immunity enhancement. Compared with the prior art, the auricularia auricular polysaccharide prepared by utilizing the technical solution provided by the invention is remarkably improved in terms of yield, oxidation resistance and immunity enhancement.

Description

technical field [0001] The invention relates to the field of biotechnology, in particular to a method for extracting polysaccharides from black fungus based on puffing treatment, as well as its preparation and application. Background technique [0002] With the advancement of science and technology and the improvement of living standards, people's pursuit of high-quality life, health and comfort is becoming more and more intense. Fungal polysaccharides are currently the most promising new resource for health food and medicine. Scientific experiments have shown that fungal polysaccharides have anti-tumor activity, strong inhibitory effect on cancer cells, and play an important role in immune regulation, lowering blood pressure, lowering blood fat, and antithrombotic. At present, the research on the relationship between the structure, properties and pharmacodynamics of polysaccharides has become one of the most active research fields in life sciences. The main active ingredi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08B37/00A61K9/16A61K9/20A61K31/715A61P37/04A61P39/06
CPCA61K9/1652A61K9/2059A61K31/715A61P37/04A61P39/06C08B37/0003
Inventor 孔祥辉张介驰陈喜君于德水杨国力张丕奇马银鹏陈鹤戴肖东王佳龙
Owner INST OF MICROBIOLOGY HEILONGJIANG ACADEMY OF SCI
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