Aquagel, preparation method therefor and application of aquagel

A hydrogel and reaction technology, used in medical science, bandages, etc., can solve the problems of insignificant bacteriostatic effect and drug resistance, and achieve the effects of no cytotoxicity, reduction of reaction steps, and mild reaction conditions.

Active Publication Date: 2019-02-01
GUANGDONG PROV MEDICAL INSTR INST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

CN107496976A discloses the method for preparing chitosan hydrogel, this hydrogel has antibacterial type and system does not need to add antibacterial agent additionally, but this gel needs to add the glutaraldehyde that has cytotoxicity as cross-linking agent
CN102675651A discloses a preparation method of chitosan hydrogel for antibacterial dressings, but additional biguanide salts are added to the gel system to play a bacteriostatic effect, and biguanide salt antibacterial agents have certain cytotoxicity, and long-term use will also produce drug resistance
For some existing chitosan gels, the antibacterial effect of chitosan alone is not obvious

Method used

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  • Aquagel, preparation method therefor and application of aquagel
  • Aquagel, preparation method therefor and application of aquagel

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preparation example Construction

[0035] A preparation method of the hydrogel comprises mixing and reacting an O-quaternary ammonium salt chitosan solution and an aldehyde sodium alginate solution to obtain a product with a structure shown in formula (1).

[0036] Further, in the preparation method, the O-quaternary ammonium salt chitosan is prepared by modifying chitin with a quaternary ammonium salt modifier.

[0037] What is explained here is that O-quaternary ammonium chitosan refers to the introduction of quaternary ammonium salt at the C-6 position in the molecular structure of chitosan to synthesize O-quaternary ammonium chitosan with a certain degree of substitution. The following quaternary ammonium chitosan refers to O-quaternary ammonium chitosan unless otherwise specified.

[0038] Further, in the preparation method, the aldehyde sodium alginate is prepared from sodium alginate through an oxidation reaction.

[0039] Further, the mixed reaction is a Schiff base reaction.

[0040] The preparation ...

Embodiment 1

[0079] The hydrogel preparation method of embodiment 1 is as follows:

[0080] Weigh 1g of chitin, dissolve it in 30mL of isopropanol, stir at room temperature for 2 hours, add 7g of (3-chloro-2-hydroxypropyl)trimethylammonium chloride reagent, stir for 2 hours, and then add to the reaction solution 40wt% NaOH solution was added to the reaction solution at 50°C for 8 hours. After the reaction is completed, filter, remove the supernatant, wash repeatedly with ethanol, and then dry at 40° C. to remove the ethanol to obtain a crude quaternized chitosan product. The crude product was dissolved in 10 ml of distilled water, fully stirred and filtered, the filtrate was washed with 30 ml of acetone, the precipitate was precipitated and filtered, and the step of washing with acetone was repeated 3 times. Dissolve the precipitate obtained by filtration with 20 mL of distilled water, dialyze the solution for 2 days with a dialysis bag to remove small molecular substances; filter with su...

Embodiment 2

[0085] The hydrogel preparation method of embodiment 2 is as follows:

[0086] Weigh 1g of chitin, dissolve it in 30mL of isopropanol, stir at room temperature for 2 hours, add 3.7g of 2,3-epoxypropyltrimethylammonium chloride reagent, stir for 2 hours, and then add 50wt% NaOH solution was reacted at 70°C for 8 hours. After the reaction is completed, filter, remove the supernatant, wash repeatedly with ethanol, and then dry at 40° C. to remove the ethanol to obtain a crude quaternized chitosan product. The crude product was dissolved in 10 ml of distilled water, fully stirred and filtered, the filtrate was washed with 30 ml of acetone, the precipitate was precipitated and filtered, and the step of washing with acetone was repeated 3 times. Dissolve the precipitate obtained by filtration with 20 mL of distilled water, dialyze the solution for 2 days with a dialysis bag to remove small molecular substances; filter with suction and dry in vacuum to obtain purified quaternary amm...

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Abstract

The invention discloses aquagel, a preparation method therefor and an application of the aquagel. The aquagel is a product obtained through subjecting an O-quaternary ammonium salt chitosan solution and an aldehyde-group sodium alginate solution to a mixed reaction. Simultaneously, the invention further discloses the preparation method for the aquagel. The method comprises the following steps: 1)modifying chitin to prepare O-quaternary ammonium salt chitosan; 2) modifying sodium alginate to prepare aldehyde-group sodium alginate; and 3) preparing the aquagel. The invention further discloses the application of the aquagel. The aquagel disclosed by the invention has bacterial inhibition, moisture preserving property and high biocompatibility and has a broad application prospect in the fields of biomedicine, reshaping facial beautification and the like. Aquagel products can serve as wound surface dressing in medical clinics and products of skin repairing, nursing and the like of reshaping facial beautification.

Description

technical field [0001] The invention relates to a hydrogel and its preparation method and application. Background technique [0002] Hydrogel is a polymer with a unique three-dimensional network structure formed by cross-linking one or several hydrophilic polymer materials. It can absorb water and swell, absorb a large amount of water and store water without dissolution. The very similar structure and properties of the matrix have broad application prospects in the fields of biomedicine and regenerative medicine. The disadvantages of drying and causing scars on the wound surface. Hydrogels can be divided into chemical cross-linked hydrogels and physical cross-linked hydrogels according to different cross-linking methods. Chemical cross-linked hydrogels are formed by chemical cross-linking between molecules, and covalent bonds between polymer chains The form of bonds forms a three-dimensional network structure, and the cross-linking process is irreversible. This kind of hyd...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08J3/075C08L5/08C08L5/04A61L26/00
CPCA61L26/0052A61L26/008C08J3/075C08J2305/04C08J2305/08C08L5/08C08L5/04
Inventor 耿志杰刘群峰裴大婷刘金彦张丽周小雁张锦
Owner GUANGDONG PROV MEDICAL INSTR INST
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