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Drug loading biological activity glass complex calcium phosphate bone cement and application thereof

A technology of bioactive glass and calcium phosphate bone cement, which is applied in the fields of medical science, tissue regeneration, prosthesis, etc., can solve the problems of lack of macroporous structure of osteoblasts, slow degradation, low mechanical properties of calcium phosphate bone cement, etc., to achieve Increase porosity, increase compressive strength, and facilitate cell proliferation and adhesion

Active Publication Date: 2019-02-15
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] At present, the mechanical properties of calcium phosphate bone cement materials are low, and the biodegradation is slow, and the cured bone cement spontaneously forms a microporous structure, lacking a macroporous structure for osteoblasts to grow into, etc., thus limiting its application.

Method used

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  • Drug loading biological activity glass complex calcium phosphate bone cement and application thereof
  • Drug loading biological activity glass complex calcium phosphate bone cement and application thereof
  • Drug loading biological activity glass complex calcium phosphate bone cement and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] The preparation method of drug-loaded bioactive glass microspheres described in this embodiment is:

[0037] (1) Dissolve 0.65g of calcium nitrate in a mixed solution of 180mL of deionized water and 70mL of absolute ethanol, mix uniformly to form a water phase solution; dissolve ethyl orthosilicate in cyclohexane to form an oil phase solution;

[0038] (2) Mix the water phase solution and the oil phase solution, then add 0.22g of cetyltrimethylammonium bromide and stir evenly, then add 3mL of ammonia water, stir for 3 hours, then add 0.35g of triethyl phosphate, stir for reaction , to obtain a bioactive glass gel solution, wherein the molar ratio of ethyl orthosilicate, triethyl phosphate and calcium nitrate is 80:5:15;

[0039] (3) Centrifuge the bioactive glass gel solution, wash the precipitate, and dry it at 60°C to obtain a bioactive glass gel powder;

[0040] (4) Heat-treat the obtained bioactive glass gel powder in a high-temperature furnace at 650° C. for 8 hou...

Embodiment 2

[0044] As an embodiment of the drug-loaded bioactive glass composite calcium phosphate bone cement of the present invention, the drug-loaded bioactive glass composite calcium phosphate bone cement described in this embodiment includes a solid phase powder and a solidification liquid, and the solid phase powder Comprising the drug-loaded bioactive glass microspheres and the calcium phosphate bone cement solid phase powder prepared in Example 1; the mass ratio of the drug-loaded bioactive glass microspheres and the calcium phosphate bone cement solid phase powder is 0.04:1; the calcium phosphate bone The cement solid phase powder comprises α-tricalcium phosphate, calcium carbonate and strontium-doped octacalcium phosphate; in the calcium phosphate bone cement solid phase powder, the molar ratio of strontium to calcium is: strontium:calcium=0.05:1; the calcium The molar ratio of the sum of strontium and phosphorus is: calcium+strontium: phosphorus=1.1:1; the degree of substitution o...

Embodiment 3

[0048] As an embodiment of the drug-loaded bioactive glass composite calcium phosphate bone cement of the present invention, the drug-loaded bioactive glass composite calcium phosphate bone cement described in this embodiment includes a solid phase powder and a solidification liquid, and the solid phase powder Comprising the drug-loaded bioactive glass microspheres and the calcium phosphate bone cement solid phase powder prepared in Example 1; the mass ratio of the drug-loaded bioactive glass microspheres and the calcium phosphate bone cement solid phase powder is 0.04:1; the calcium phosphate bone The cement solid phase powder comprises α-tricalcium phosphate, calcium carbonate and strontium-doped octacalcium phosphate; in the calcium phosphate bone cement solid phase powder, the molar ratio of strontium to calcium is: strontium:calcium=0.1:1; the calcium The molar ratio of the sum of strontium and phosphorus is: calcium+strontium: phosphorus=1.2:1; the degree of substitution ...

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Abstract

The invention discloses drug loading biological activity glass complex calcium phosphate bone cement and application thereof. According to the invention, drug loading biological activity glass microspheres are added into the calcium phosphate bone cement, the in vivo degradation rate of the biological activity glass microspheres is relatively high, a porous structure inside the calcium phosphate bone cement can be adjusted, a bone-like apatite layer can be formed on the surface of each biological activity glass microsphere, and the drug loading biological activity glass complex calcium phosphate bone cement has good biological activity; and simultaneously, loaded drugs are released while the biological activity glass microspheres are degraded, so that the bone cement has the effects of bone remodeling and drug therapy; and the cell proliferation is promoted by using strontium-doped octacalcium phosphate modified alpha-TCP bone cement. The calcium phosphate bone cement has moderate timeof coagulation, is good in syringeability, mechanical strength and biocompatibility, and meets clinic requirements of bone repair.

Description

technical field [0001] The invention relates to the technical field of calcium phosphate bone cement, in particular to a drug-loaded bioactive glass composite calcium phosphate bone cement and an application thereof. Background technique [0002] Calcium Phosphate Cement (CPC) was successfully developed by Brown and Chow in the 1990s. It is a self-curing non-ceramic hydroxyapatite artificial bone material. It is composed of solid phase powder and solidification liquid mixed according to a certain ratio to form an easy-to-shape slurry, which solidifies itself in a short time, and the final hydration product is apatite, which is similar to the inorganic composition and crystal structure of human bone tissue. . CPC has good osteoconductivity and biocompatibility, and can be shaped arbitrarily during surgery to fill bone defects of various shapes. It has been widely used in the fields of bone defect repair, maxillofacial surgery repair and drug carrier. [0003] At present, ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/10A61L27/12A61L27/54A61L27/56A61L27/58
CPCA61L27/10A61L27/12A61L27/54A61L27/56A61L27/58A61L2300/102A61L2300/112A61L2300/412A61L2300/604A61L2430/02
Inventor 车七石
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD
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