Calcium phosphate-based bone repair scaffold and preparation method thereof

A calcium phosphate-based bone and calcium phosphate bone technology, which can be used in coatings, medical science, prostheses, etc., can solve the problems of inability to manufacture bone repair scaffolds, inability to control pore size, toxic and side effects of pore-forming agents, etc. Effects on new bone formation, promotion of cell adhesion and proliferation, and enhancement of mechanical strength

Inactive Publication Date: 2019-02-26
GUANGZHOU RAINHOME PHARM&TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The preparation method of traditional porous scaffold materials is manual operation with poor reproducibility; the added pore-forming agent has potential tox

Method used

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  • Calcium phosphate-based bone repair scaffold and preparation method thereof
  • Calcium phosphate-based bone repair scaffold and preparation method thereof
  • Calcium phosphate-based bone repair scaffold and preparation method thereof

Examples

Experimental program
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Example Embodiment

[0032] Example 1

[0033] A preparation method of calcium phosphate-based bone repair scaffold, characterized in that, comprising the following steps:

[0034] (1) Mix the calcium phosphate bone cement solid phase powder and the solidification liquid, and the solid-liquid ratio of the calcium phosphate bone cement solid phase powder and the solidification liquid is 1g: 0.45mL, and stir evenly to obtain a calcium phosphate bone cement slurry. The solid phase powder includes polyethylene glycol, α-tricalcium phosphate, strontium-doped octacalcium phosphate and / or strontium-doped amorphous calcium phosphate; in the solid phase powder, the molar ratio of strontium and calcium is: strontium: calcium = 0.1:1; the molar ratio of the sum of calcium and strontium to phosphorus is: calcium+strontium:phosphorus=1.1:1; the mass fraction of polyethylene glycol in the solid phase powder is 0.5%;

[0035] Dissolving hydroxypropyl methyl cellulose and carboxymethyl chitosan in a 0.5 mol / L ci...

Example Embodiment

[0043] Example 2

[0044] A preparation method of calcium phosphate-based bone repair scaffold, characterized in that, comprising the following steps:

[0045] (1) Mix the calcium phosphate bone cement solid phase powder and the solidification liquid, and the solid-liquid ratio of the calcium phosphate bone cement solid phase powder and the solidification liquid is 1g: 0.45mL, and stir evenly to obtain a calcium phosphate bone cement slurry. The solid phase powder includes polyethylene glycol, α-tricalcium phosphate, strontium-doped octacalcium phosphate and / or strontium-doped amorphous calcium phosphate; in the solid phase powder, the molar ratio of strontium and calcium is: strontium: calcium = 0.7:1; the molar ratio of the sum of calcium and strontium to phosphorus is: calcium+strontium:phosphorus=1.3:1; the mass fraction of polyethylene glycol in the solid phase powder is 0.6%;

[0046] Dissolving hydroxypropyl methyl cellulose and carboxymethyl chitosan in a 0.5 mol / L ci...

Example Embodiment

[0054] Example 3

[0055] A preparation method of calcium phosphate-based bone repair scaffold, characterized in that, comprising the following steps:

[0056] (1) Mix the calcium phosphate bone cement solid phase powder and the solidification liquid, the solid-liquid ratio of the calcium phosphate bone cement solid phase powder and the solidification liquid is 1g: 0.5mL, and stir evenly to obtain a calcium phosphate bone cement slurry, wherein the The solid phase powder includes polyethylene glycol, α-tricalcium phosphate, strontium-doped octacalcium phosphate and / or strontium-doped amorphous calcium phosphate; in the solid phase powder, the molar ratio of strontium and calcium is: strontium: calcium = 0.7:1; the molar ratio of the sum of calcium and strontium to phosphorus is: calcium+strontium:phosphorus=1.3:1; the mass fraction of polyethylene glycol in the solid phase powder is 0.7%;

[0057] Dissolving hydroxypropyl methyl cellulose and carboxymethyl chitosan in a 0.5 m...

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Abstract

The invention discloses a calcium phosphate-based bone repair scaffold and a preparation method thereof. Calcium phosphate bone cement is used as a raw material and is combined with a 3D printing technology to obtain a calcium phosphate bone cement scaffold with through macropores; a dopamine solution is used for modifying the surface of the scaffold; dopamine forms a polydopamine layer on the surface of the scaffold through self-oxidation under alkaline conditions; polydopamine has good viscosity and biocompatibility, can be used as an adhering coating layer of BMP-2, improves the content offixed BMP-2, and promotes cell adhesion and proliferation; the BMP-2 loaded on the scaffold can also effectively promote the proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells. The prepared calcium phosphate-based bone repair scaffold has through macropores, meets the mechanical strength requirements of cancellous bones, has excellent biocompatibility, can effectively promote bone tissue regeneration, and has potential application value in the field of bone tissue repair.

Description

technical field [0001] The invention relates to the technical field of bone repair materials, in particular to a calcium phosphate-based bone repair bracket and a preparation method thereof. Background technique [0002] Bone is an important tissue of the human body. Although it has bone regeneration and self-repair capabilities, for bone defects caused by tumors, trauma, and abnormal bone growth, in the case that bone self-repair alone cannot heal, it is necessary to use implant materials to assist the damage. Tissue repair and healing. From the perspective of bone tissue self-healing, an ideal bone repair scaffold needs to have good biocompatibility, biodegradability, three-dimensional porous structure, and a complex shape that matches the defect site. The porous bone repair scaffold has a high specific surface area and space, which is conducive to the loading of active factors, cell adhesion and growth, deposition of extracellular matrix, entry of nutrients and oxygen, d...

Claims

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Application Information

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IPC IPC(8): A61L27/42A61L27/34A61L27/56A61L27/54B33Y80/00
CPCA61L27/34A61L27/425A61L27/54A61L27/56A61L2300/252A61L2300/412A61L2300/606A61L2420/02A61L2420/08A61L2430/02B33Y80/00C08L89/00C08L79/02C08L1/284C08L5/08C08L71/02
Inventor 车七石
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD
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