Rapidly- degradable injectable type bone cement and application thereof

A fast-degrading, injection-type technology, used in medical science, tissue regeneration, prostheses, etc., can solve the problem of slow degradation rate of calcium phosphate bone cement, shorten the setting time, improve the compressive strength, and promote the growth of bone cells. the effect of entering

Active Publication Date: 2019-03-01
GUANGZHOU RAINHOME PHARM&TECH CO LTD
View PDF7 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the deficiencies of the prior art and provide a rapidly degradable inje

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Rapidly- degradable injectable type bone cement and application thereof
  • Rapidly- degradable injectable type bone cement and application thereof
  • Rapidly- degradable injectable type bone cement and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] As an embodiment of the rapidly degradable injectable bone cement described in the present invention, the rapidly degradable injectable bone cement described in this embodiment includes solid phase powder and solidification liquid;

[0035] The solid phase powder includes calcium sulfate, bioactive glass and calcium phosphate bone cement solid phase powder; the mass ratio of the calcium sulfate to the calcium phosphate bone cement solid phase powder is 0.01:1; the bioactive glass and calcium phosphate bone cement The mass ratio of the cement solid phase powder is 0.01:1; the calcium phosphate bone cement solid phase powder comprises α-tricalcium phosphate, calcium carbonate, strontium-doped octacalcium phosphate and amorphous calcium phosphate; the α-tricalcium phosphate and The mass ratio of calcium carbonate is 1:0.05; the mass ratio of the α-tricalcium phosphate to amorphous calcium phosphate is 1:0.1; in the calcium phosphate bone cement solid phase powder, the molar...

Embodiment 2

[0045] As an embodiment of the rapidly degradable injectable bone cement described in the present invention, the rapidly degradable injectable bone cement described in this embodiment includes solid phase powder and solidification liquid;

[0046] The solid phase powder includes calcium sulfate, bioactive glass and calcium phosphate bone cement solid phase powder; the mass ratio of the calcium sulfate to the calcium phosphate bone cement solid phase powder is 0.04:1; the bioactive glass and calcium phosphate bone cement The mass ratio of the cement solid phase powder is 0.04:1; the calcium phosphate bone cement solid phase powder comprises α-tricalcium phosphate, calcium carbonate, strontium-doped octacalcium phosphate and amorphous calcium phosphate; the α-tricalcium phosphate and The mass ratio of calcium carbonate is 1:0.05; the mass ratio of the α-tricalcium phosphate to amorphous calcium phosphate is 1:0.1; in the calcium phosphate bone cement solid phase powder, the molar...

Embodiment 3

[0056] As an embodiment of the rapidly degradable injectable bone cement described in the present invention, the rapidly degradable injectable bone cement described in this embodiment includes solid phase powder and solidification liquid;

[0057] The solid phase powder includes calcium sulfate, bioactive glass and calcium phosphate bone cement solid phase powder; the mass ratio of the calcium sulfate to the calcium phosphate bone cement solid phase powder is 0.06:1; the bioactive glass and calcium phosphate bone cement The mass ratio of the cement solid phase powder is 0.04:1; the calcium phosphate bone cement solid phase powder comprises α-tricalcium phosphate, calcium carbonate, strontium-doped octacalcium phosphate and amorphous calcium phosphate; the α-tricalcium phosphate and The mass ratio of calcium carbonate is 1:0.1; the mass ratio of the α-tricalcium phosphate to amorphous calcium phosphate is 1:0.15; in the calcium phosphate bone cement solid phase powder, the molar...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
Concentrationaaaaaaaaaa
Particle sizeaaaaaaaaaa
Particle sizeaaaaaaaaaa
Login to view more

Abstract

The invention discloses rapidly -degradable injectable type bone cement and application thereof. According to the rapidly -degradable injectable type bone cement and the application thereof, calcium sulfate with good biocompatibility and the high degradation rate and bioactive glass are added into calcium phosphate bone cement, the degradation rate of the calcium phosphate bone cement is adjustedby controlling the additive amount of the calcium sulfate and the bioactive glass, meanwhile, after degradation of the calcium sulfate and the bioactive glass in the bone cement, a porous structure isformed in the bone cement, and bone cement degradation and the ingrowth of bone cells are promoted; and strontium-doped octacalcium phosphate serves as modified alpha-TCP bone cement of Sr2+ sources,the setting time can be shortened, the compressive strength of the bone cement is improved, and the modified alpha-TCP bone cement adopted the strontium-doped octacalcium phosphate has a more stableand appropriate ion releasing rate, and cell proliferation is promoted.

Description

technical field [0001] The invention relates to the technical field of calcium phosphate bone cement, in particular to a rapidly degradable injectable bone cement and its application. Background technique [0002] Calcium Phosphate Cement (CPC) was successfully developed by Borwn and Chow in the 1990s. It is a self-curing non-ceramic hydroxyapatite artificial bone material. It is composed of solid phase powder and solidification liquid mixed according to a certain ratio to form an easy-to-shape slurry, which solidifies itself in a short time, and the final hydration product is apatite, which is similar to the inorganic composition and crystal structure of human bone tissue. . CPC has good osteoconductivity and biocompatibility, and can be shaped arbitrarily during surgery to fill bone defects of various shapes. It has been widely used in the fields of bone defect repair, maxillofacial surgery repair and drug carrier. [0003] The degradation and absorption process of the c...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61L27/20A61L27/02A61L27/10A61L27/12A61L27/50A61L27/56A61L27/58
CPCA61L27/025A61L27/10A61L27/12A61L27/20A61L27/50A61L27/56A61L27/58A61L2400/06A61L2430/02C08L5/00
Inventor 车七石
Owner GUANGZHOU RAINHOME PHARM&TECH CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap