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Magnetic Iron Oxide Nanoparticles Containing Metal Atom Clusters and Its Preparation and Application

A technology of metal atomic clusters and magnetic iron oxide, applied in the direction of iron oxide, iron oxide/iron hydroxide, magnetic objects, etc., can solve the problems of complex preparation process, difficult control of reaction process, and limited improvement of application performance

Active Publication Date: 2021-08-20
陕西佰磁康达医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the particles prepared by these methods have some shortcomings, such as: ferrite or cubic morphology can only improve the magnetic properties and corresponding application performance; and for the ferrite core / shell nanostructure, due to its complicated preparation process, make the reaction process difficult to control

Method used

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  • Magnetic Iron Oxide Nanoparticles Containing Metal Atom Clusters and Its Preparation and Application
  • Magnetic Iron Oxide Nanoparticles Containing Metal Atom Clusters and Its Preparation and Application
  • Magnetic Iron Oxide Nanoparticles Containing Metal Atom Clusters and Its Preparation and Application

Examples

Experimental program
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Effect test

Embodiment 1

[0036] The preparation method of magnetic iron oxide nanoparticles (Iron cluster iron oxide, ICIO) containing iron atom clusters: iron acetylacetonate Fe(acac) 3 (0.4mmol), oleic acid (6mmol), oleylamine (6mmol), trioctylamine (30mL), stirred well under nitrogen atmosphere to obtain a homogeneous mixture. Heat the mixture to 200°C for 1 h, then increase the nitrogen flow to add iron acetylacetonate Fe(acac) 3 (0.05 mmol) was heated to 340° C. and refluxed for 2 h to obtain a dark brown mixture, which was naturally cooled to room temperature. Add 10mL of alcohol to the black-brown mixture, the black substance is precipitated, and then centrifuged, the black substance obtained by centrifugation is dissolved in 10mL of n-hexane, and centrifuged at 5000rpm for 10min to remove the undispersed residue; centrifuged to obtain The product was precipitated with alcohol, and centrifuged at 5000 rpm for 10 min to remove the solvent to obtain magnetic iron oxide nanoparticles containing i...

Embodiment 2

[0039] The preparation method of magnetic iron oxide nanoparticles (Iron cluster iron oxide, ICIO) containing iron atom clusters: iron oleate Fe(OA) 3 (0.4mmol), erucic acid (8mmol), octadecylamine (4mmol), octylamine (40mL), stirred well under nitrogen atmosphere to obtain a homogeneous mixture. Heat the mixture to 150°C, add and keep for 1h, then increase the flow of nitrogen to add iron acetylacetonate Fe(acac) 3 (0.05 mmol) was heated to 200° C. for 8 h under reflux to obtain a dark brown mixture, and the dark brown mixture was naturally cooled to room temperature. Subsequent processing is the same as in Example 1.

Embodiment 3

[0041] Preparation method of magnetic iron oxide nanoparticles (Iron cluster iron oxide, ICIO) containing iron atom clusters: iron pentacarbonyl Fe(CO) 5 (0.04mmol), stearic acid (1mmol), oleylamine (10mmol), tributylamine (40mL), stirred well under nitrogen atmosphere to obtain a homogeneous mixture. Heat the mixture to 300°C and keep it for 1h, then increase the nitrogen flow and add iron oleate Fe(OA) 3 (0.005 mmol) was heated to 360° C. and refluxed for 0.5 h to obtain a dark brown mixture, which was naturally cooled to room temperature. Subsequent processing is the same as in Example 1.

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Abstract

The invention provides magnetic iron oxide nanoparticles containing metal atomic clusters, the metal atomic clusters are embedded in iron oxide crystal matrix, and the content of the metal atomic clusters accounts for 0.1-15%. The present invention also provides a method for preparing the above-mentioned magnetic iron oxide nanoparticles containing metal atomic clusters. The metal precursors of iron oxide, organic acids, and organic amines are dissolved in an organic solvent in proportion to form a uniform reaction system, and then the After the reaction system is heated to 150-350°C in an inert gas atmosphere, the metal atom cluster precursor is added, and the temperature is raised to reflux until the precursor is completely decomposed. The nanoparticle of the present invention improves the magnetic properties of the magnetic iron oxide particles due to the chimera of metal atomic clusters, and the iron oxide fully ensures the stability of the properties of the nanoparticle, so it can be better applied to biomedical detection and treatment and other fields.

Description

technical field [0001] The invention relates to the technical field of magnetic iron oxide, in particular to a magnetic iron oxide nanoparticle containing metal atom clusters and its preparation and application. Background technique [0002] In recent years, the study of magnetic nanoparticles has aroused widespread interest in various disciplines, among which iron oxide, as an important magnetic material, has good biocompatibility, in addition to being used in magnetic fluids, catalysts and magnetic recording materials It also has a wide range of applications in bioseparation, detection, targeted drugs and medical imaging, and has been used in preclinical or clinical practice for iron supplements (such as ferumoxytol), magnetic resonance imaging contrast agents (such as ), magnetic hyperthermia (such as European regulatory approved ) and drug carriers. In order to prepare magnetic iron oxide nanoparticles with good biocompatibility, excellent magnetic properties and sta...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C01G49/06B82Y40/00A61K49/06H01F1/11
CPCA61K49/06H01F1/11B82Y40/00C01G49/06C01P2002/72C01P2004/03C01P2004/04C01P2004/64C01P2006/42C01P2002/54C01G49/02C01G53/00C01G51/00B82Y5/00B82Y25/00H01F1/0054A61K49/1887H01F1/058
Inventor 樊海明刘晓丽彭明丽
Owner 陕西佰磁康达医疗科技有限公司