Preparation method of lymphatic targeted molybdenum sulfide nanosheet and product thereof

A nano-sheet and lymphatic targeting technology, which is applied in the direction of molybdenum sulfide, medical preparations with non-active ingredients, medical preparations containing active ingredients, etc., can solve the problems of few reports on molybdenum sulfide materials, and avoid killing normal cells , The preparation method is simple and the effect of easy preparation

Inactive Publication Date: 2019-03-19
SHANGHAI NAT ENG RES CENT FORNANOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are not many reports on functional molybdenum sulfide materials

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] A lymphatic targeting molybdenum sulfide hybrid nanosheet, prepared according to the following steps:

[0023] a. Add 1 mmol of ammonium molybdate tetrahydrate, 30 mmol of thiourea, 30 mmol of trisodium citrate and 50 mmol of cadmium chloride solution to 35 ml of deionized water successively, stir vigorously for 30 min, and then transfer the mixed solution into Put it into a high-pressure reactor and make it react continuously for 24 h under the condition of 200 degrees. After the reaction, the temperature was lowered to room temperature and taken out, and centrifuged at 8000 rpm for 10 min to obtain a black solid product. Wash with deionized water and ethanol three times respectively, and obtain solid product a after vacuum freeze-drying;

[0024] b. Dissolve the above-mentioned product a in 40ml of N-methylpyrrolidone solution, and use a cell disruptor to sonicate for 6h at a power of 325W (setting 6h, ultrasonic on for 3s, ultrasonic off for 3s), centrifuge and wash ...

Embodiment 2

[0028] A lymphatic targeting molybdenum sulfide hybrid nanosheet, prepared according to the following steps:

[0029] a. Add 1 mmol of ammonium molybdate tetrahydrate, 30 mmol of thiourea, 30 mmol of trisodium citrate and 40 mmol of copper chloride solution to 35 ml of deionized water successively, stir vigorously for 30 min, and then transfer the mixed solution into Put it into a high-pressure reactor and make it react continuously for 24 h under the condition of 200 degrees. After the reaction, the temperature was lowered to room temperature and taken out, and centrifuged at 8000 rpm for 10 min to obtain a black solid product. Wash with deionized water and ethanol three times respectively, and obtain solid product a after vacuum freeze-drying;

[0030] b. Dissolve the above-mentioned product a in 40ml of dimethylamide solution, and use a cell disruptor to sonicate for 6h at a power of 325W (setting 6h, ultrasonic on for 3s, ultrasonic off for 3s), centrifuge, wash, The prod...

Embodiment 3

[0034] A lymphatic targeting molybdenum sulfide hybrid nanosheet, prepared according to the following steps:

[0035] a. Add 1 mmol of ammonium molybdate tetrahydrate, 30 mmol of thiourea, 30 mmol of trisodium citrate and 50 mmol of copper chloride solution to 35 ml of deionized water successively, stir vigorously for 30 min, and then transfer the mixed solution into Put it into a high-pressure reactor and make it react continuously for 24 h under the condition of 200 degrees. After the reaction, the temperature was lowered to room temperature and taken out, and centrifuged at 8000 rpm for 10 min to obtain a black solid product. Wash with deionized water and ethanol three times respectively, and obtain solid product a after vacuum freeze-drying;

[0036] b. Dissolve the above-mentioned product a in 40ml of dimethyl sulfoxide solution, and use a cell disruptor to sonicate for 6h at a power of 325W (setting 6h, ultrasonic on for 3s, ultrasonic off for 3s), centrifuge and wash ,...

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PUM

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Abstract

The invention relates to a preparation method of a lymphatic targeted molybdenum sulfide nanosheet and a product thereof. The molybdenum sulfide is synthesized by means of a hydrothermal synthetic method, and sulfide nanoparticles are embedded at the same time, so that the spaces among layers are enlarged, and peeling is facilitated further. By taking an organic solvent as a reaction solvent, molybdenum sulfide is peeled by a liquid phase to prepare the two-dimensional molybdenum sulfide nanosheet. Finally, modified by hyaluronic acid, the lymphatic targeted two-dimensional molybdenum sulfidenanosheet is prepared. The invention relates to the novel method of preparing molybdenum sulfide. The method, by being applied to treating cancers clinically, can achieve targeted photothermal therapyof tumor cells and prevent normal cells from being killed.

Description

technical field [0001] The invention relates to the field of preparation of nanomaterials, in particular to a preparation method of a lymphatic-targeting molybdenum sulfide hybrid nano-sheet and its product and application, which have a lymphatic-targeting function. Background technique [0002] Cancer is one of the major diseases that seriously threaten human life and health. In recent years, the incidence of cancer has continued to increase. Although surgical treatment, radiotherapy and chemotherapy can be performed on cancer, surgical treatment has almost no therapeutic effect on metastatic cancer cells. Radiotherapy Chemotherapy and chemotherapy kill normal cells as well as cancer cells. Due to these limitations of traditional cancer treatment methods, there is currently no effective method for tumor treatment. [0003] In 2004, Novoselov and others from the University of Manchester successfully stripped graphene, which opened up a new field of material research. After t...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K47/02A61K47/36A61P35/00B82Y40/00B82Y5/00C01G39/06
CPCA61K41/0052A61K47/02A61K47/36A61P35/00B82Y5/00B82Y40/00C01G39/06C01P2004/20
Inventor 何丹农朱君曹文涛刘睿金彩虹
Owner SHANGHAI NAT ENG RES CENT FORNANOTECH
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