Absorbable oral cavity restoration membrane and preparation method thereof

Abstract

The invention discloses an oral cavity restoration membrane and a preparation method thereof. The oral cavity restoration membrane uses gelatin and polycaprolactone as raw materials, which are subjected to a static spinning process respectively for obtaining a membrane formed by nanometer stage fiber; the lamination is performed in sequence of a gelatin layer, a polycaprolactone layer and a gelatin layer to obtain the three-layer structure oral cavity restoration membrane with the gradually changed fiber diameter. The preparation method of the oral cavity restoration membrane comprises the following steps of preparing a gelatin solution, preparing a gelatin membrane, drying the gelatin membrane, preparing a polycaprolactone solution, preparing a polycaprolactone membrane, drying the polycaprolactone membrane, laminating the gelatin fiber membrane and the polycaprolactone fiber membrane, and performing cutting, inner packaging, sterilization and outer packaging. The method has the advantages that the keratinized gum growth can be effectively guided; the restoration time is shortened; the membrane is applied to the oral cavity and maxillofacial soft tissue restoration in a wider range.

Description

technical field [0001] The invention belongs to the technical field of biological materials and tissue engineering, and in particular relates to an absorbable oral cavity adsorption film and a preparation method thereof. Background technique [0002] Oral tissue defects need to be repaired. At present, oral tissue defects mainly include loss of periodontal tissue, insufficient or missing width of attached gingiva, defect after maxillofacial tumor resection, wound dehiscence after GBR, and donor site defect of connective tissue transplantation. , maxillary sinus fistula, wound closure after mandibular impacted tooth extraction, gingival recession, root surface exposure, abnormal frenulum attachment position / vestibular groove too shallow, buccal mucosal tissue defect, and prevention of gustatory sweating syndrome, etc. [0003] At present, in the repair of oral tissue defects, autologous tissue transplantation is limited, and it will cause additional pain to the patient. It al...

AI Technical Summary

Problems solved by technology

[0003] Currently used in the repair of oral tissue defects, autologous tissue transplantation is limited, and it will cause additional pain to the patient, and it also has high requirements for the doctor's technical level, and the chair time is longer

ADM (Acellular Dermal Matrix), CM (Collagen Matrix Membrane) and other tissue engineering materials have problems such as relatively narrow application range, complications, long repair time, and unsatisfactory long-term effects.

PRF (platelet-rich fibrin) is not suitable for a large number of materials, and the existing centrifugation methods and equipment also determine that only small-area PRF can be prepared, which is difficult to apply to large-scale defects