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A kind of preparation method of nano-gold particles with different particle sizes

A technology of nano-gold particles and particle size, which is applied in the direction of nanotechnology, nanotechnology, metal processing equipment, etc., can solve the problems that the shape and size are difficult to control, the particle size parameters of nanoparticles cannot be adjusted, and the process parameters are difficult to control. Achieve the effects of adjustable particle size parameters, easy adjustment of preparation process parameters, and good biocompatibility

Active Publication Date: 2022-03-29
YUNNAN NORMAL UNIV
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  • Abstract
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AI Technical Summary

Problems solved by technology

[0007] Many existing technologies use a reducing agent to prepare nano-gold particles in a one-time reduction method. The process parameters of this preparation method are difficult to control, and the prepared nano-gold particles often have uneven particle sizes.
Especially for the preparation of large-diameter gold nanoparticles, there are often problems that the shape and size are difficult to control
However, other physical methods such as impact, extrusion, collision, shearing or friction are used to prepare gold nanoparticles, and there are disadvantages such as complex methods, inconvenient operation and high cost.
Moreover, the particle size parameters of the prepared nanoparticles cannot be adjusted and the size is not uniform, which limits the application of gold nanoparticles in medical testing, chemical sensing, environmental monitoring and other fields.
It is also not conducive to the study of the particle size effect of gold nanoparticles on cell viability, surface-enhanced Raman scattering and fluorescent labeling, etc.

Method used

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  • A kind of preparation method of nano-gold particles with different particle sizes
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  • A kind of preparation method of nano-gold particles with different particle sizes

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preparation example Construction

[0029] Below in conjunction with accompanying drawing, preparation method of the present invention is further described;

[0030] Such as figure 1 As shown, the preparation method of gold nanoparticles with different particle sizes provided by the embodiments of the present invention:

[0031] S101: Prepare 0.1M sodium potassium tartrate solution and 1% chloroauric acid solution as stock solution, and set aside;

[0032] S102: In a 100mL round-bottomed flask, add 50mL of 0.25mM chloroauric acid solution, and heat to boiling under magnetic stirring; add 1mL of 0.1M sodium potassium tartrate solution, and react under reflux for 30min to obtain translucent wine red colloidal gold Sol, naturally cooled to room temperature, set aside;

[0033] S103: Take a certain amount of the above-mentioned wine red colloidal gold solution as the seed growth solution and dilute it to 20mL, heat the growth solution to 80°C; add 10mL of 1mM chloroauric acid solution and 10mL of 5mM tartaric acid...

Embodiment 1

[0042] (1) configure 0.1M sodium potassium tartrate solution and 1% chloroauric acid solution for subsequent use;

[0043] (2) In a 100 mL round bottom flask, dilute 515 μL of 1% chloroauric acid stock solution to 50 mL to obtain a 0.25 mM chloroauric acid solution, and heat to boiling with magnetic stirring. Then quickly add 1mL of 0.1M sodium potassium tartrate solution, and react under reflux for 30min to obtain a bright wine red colloidal gold sol, which is naturally cooled to room temperature for later use.

[0044](3) Take an appropriate amount of the above nano-gold sol for ultraviolet-visible spectroscopy (UV-Vis) analysis and transmission electron microscope (TEM) analysis.

[0045] Such as image 3 and Figure 4 As shown in A, the maximum absorption peak of the nano-gold sol is located at 524nm, and through TEM analysis, it can be known that its particle size is 28±1nm, and the particles present good monodispersity.

[0046] (4) Take appropriate amount of above-me...

Embodiment 2

[0049] (1) configure 0.1M sodium potassium tartrate solution and 1% chloroauric acid solution for subsequent use;

[0050] (2) In a 100 mL round bottom flask, dilute 515 μL of 1% chloroauric acid stock solution to 50 mL to obtain a 0.25 mM chloroauric acid solution, and heat to boiling with magnetic stirring. Then quickly add 1mL of 0.1M sodium potassium tartrate solution, and react under reflux for 30min to obtain a bright wine red colloidal gold sol, which is naturally cooled to room temperature for later use.

[0051] (3) Take 4mL of the above colloidal gold sol as the seed growth solution and dilute it to 20mL, and heat the growth solution to 80°C, then add 10mL of 1mM chloroauric acid solution and 10mL of 5mM potassium tartrate sodium solution (dropping method is simple constant speed mode and the speed is 20mL / h). After the dropwise addition is completed, the mixed solution is heated to boiling, kept boiling for 30 minutes, and then naturally cooled to room temperature ...

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Abstract

The invention belongs to the technical field of nano-metal materials, and discloses a preparation method of nano-gold particles with different particle sizes; 50 mL of 0.25 mM chloroauric acid solution is added to a round-bottomed flask, heated to boiling with magnetic stirring; potassium tartrate sodium is added Solution, reacted under reflux for 30min to obtain wine red colloidal gold sol, cooled naturally to room temperature for later use; diluted the seed growth solution to 20mL, heated to 80°C; solution; the dropwise addition is completed and the mixed solution is heated to boiling, kept boiling for more than 30 minutes, and cooled to obtain nano-gold sol; change the amount of seed growth solution or repeat the above drop-adding steps to prepare nano-gold particles with different particle sizes. The invention is simple and quick, easy to operate, easy to control the parameters of the preparation process, and can prepare nano-gold particles with uniform particle size and controllable particle size parameters.

Description

technical field [0001] The invention belongs to the technical field of nano metal materials, in particular to a method for preparing nano gold particles with different particle sizes. Background technique [0002] At present, the existing technologies commonly used in the industry are as follows: [0003] Nanomaterials have unique small size effect, quantum effect and surface interface effect, so that nanomaterials can be widely used in various fields such as medical detection, chemical sensing, environmental protection, textile and machinery industry. Gold nanoparticles have unique biocompatibility, high electron density and dielectric properties, excellent optical and catalytic properties, and have been used in microscopic labeling, chemical biosensing and biochips, food safety detection and analysis, surface catalysis and environmental protection. Conservation methods have achieved rich research results. Therefore, it is very important to study the simple, fast and safe...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22F9/24B22F1/0545B82Y40/00B82Y30/00
CPCB82Y30/00B82Y40/00B22F9/24B22F1/054
Inventor 汤俊琪欧全宏满石清石俊生
Owner YUNNAN NORMAL UNIV
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