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Organic/inorganic hybrid material of oligomeric silsesquioxane group, preparation method and application in bone tissue engineering

A siloxane-based, hybrid material technology, applied in tissue regeneration, prosthesis, medical science, etc., can solve the problem of material loss of toughness

Inactive Publication Date: 2021-08-03
QINGDAO UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] For the existing organic / inorganic composite materials used for hard tissue engineering, when subjected to body fluid erosion, the degradation rates of high molecular polymers and inorganic particles are different. The high molecular polymers degrade first, and the inorganic particles will become free nanoparticles. particles, the material will lose its toughness and cannot really meet the problem of high strength and high toughness requirements. The present invention provides a kind of organic / inorganic hybrid of oligomeric silsesquioxane (POSS) base for hard tissue engineering Material and its preparation method, prepared by click chemistry through oligomeric silsesquioxane (POSS) and organic compounds, the material is based on polyhedral oligomeric silsesquioxane network, POSS cages are covalently bonded by reactive flexible chains Connection, by changing the reactive flexible chain in the middle, the strength, toughness and self-healing properties of POSS-based organic-inorganic hybrid materials can be adjusted, and the material supports the growth and differentiation of stem cells in bone tissue engineering

Method used

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  • Organic/inorganic hybrid material of oligomeric silsesquioxane group, preparation method and application in bone tissue engineering
  • Organic/inorganic hybrid material of oligomeric silsesquioxane group, preparation method and application in bone tissue engineering
  • Organic/inorganic hybrid material of oligomeric silsesquioxane group, preparation method and application in bone tissue engineering

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] 12 mg of vinyl Poss is dissolved in 200 μl N, N-dimethylformamide, and 10.5 mg of bis (2-mercaptoethyl) ether and 1.6 mg of 2,2-dimethoxy-2-phenylbenzene. Ethyl ketone, with an oscillator to mix the solution well, and the solution was placed under an ultraviolet lamp having a wavelength of 365 nm to obtain a white organic gel. The product was placed in vacuum drying in vacuum drying in vacuo to dry, and the weight of the product was not changed, i.e., obtaining a POS group organic inorganic hybrid material (OEG1-POS). The structure is as follows:

[0032]

[0033] POSS-based organic inorganic hybrid material (OEG1-POS) is composed of POSS-based and shorter chains by chemical bonds, similar to crosslinking of inorganic materials, and therefore has a large mechanical strength, and because in Poss The organic chain is introduced into the organic inorganic hybrid material, so the toughness of the material is improved.

[0034] This material has better mechanical properties in...

Embodiment 2

[0036] 13 mg of vinyl POSS was dissolved in 200 μl N, N-dimethylformamide, and 15 mg of 3,8-dioxane-1,8-octane thiol and 1.7 mg 2,2-dimethoxy. -2-phenylstone, with an oscillator to mix the solution in an ultraviolet lamp having a wavelength of 365 nm, resulting in a white organic gel. The product was placed in vacuum drying tank at 60 ° C for vacuum drying, and the weight of the product was not changed, i.e., obtaining a POSS organic inorganic hybrid material (OEG2-POS). The structure is as follows:

[0037]

[0038] Comparative Example 1, the POSS-based organic inorganic hybrid material (OEG2-POS) prepared in Example 2, as the growth of the reactive flexible arm, the growth of the organic segment, the material surface is smooth, Figure 8 The Sem Picture of OEG2-POSS and OEG2-POSS can be seen in that the surface of the smooth material is more conducive to the growth of HAP crystals. Image 6 ).

[0039] This material has a high Young's modulus in the compression test, Figure 5 Pr...

Embodiment 3

[0041] 4.5 mg of 8 vinyl Poss is dissolved in 200 μl N, N-dimethylformamide, and 28.5 mg of dithiol-based polyethylene glycol (molecular weight 1000) and 0.6 mg of 2,2-dimethoxy-2-benzene were added. Byceticketone, the solution was sufficiently mixed with an oscillator, and the solution was placed under an ultraviolet lamp having a wavelength of 365 nm to obtain a transparent organic gel. The product was placed in vacuum drying tank at 60 ° C for vacuum drying, and the weight of the product was not changed, i.e., obtained a POS group organic inorganic hybrid material (PEG1K-POS). The structure is as follows:

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Abstract

The present invention aims at the existing organic / inorganic composite materials for hard tissue engineering. When eroded by body fluids, the high molecular polymer is first degraded, the inorganic particles will become free nanoparticles, and the material will lose its toughness. Provided are an oligomeric silsesquioxane-based organic-inorganic hybrid material, a preparation method and its application in bone tissue engineering, belonging to the technical field of biological composite materials. The spatial structure of the hybrid material is: or A is an oligomeric silsesquioxane cage, and its general structural formula is R n Si n O 1.5n , where n=6, 8, 10 or 12; B is the reactive flexible arm connecting the two cages. The present invention also provides a preparation method for preparing the above hybrid material by click chemistry and its use as a bone material in tissue engineering. The hybrid material constructed by the invention has simple reaction operation, mild conditions, and is insensitive to oxygen and water; the product has high yield and good selectivity; the product is easy to purify, the post-processing is simple, and the obtained material has very good mechanical properties and biological activity .

Description

Technical field [0001] The present invention belongs to the technical field of biocomposites, and more particularly to an oligomeric hybrid hybrid material, a preparation method, and its application in bone tissue engineering. Background technique [0002] In traditional tissue engineering applications, a key principle is to develop a bracket material that can match natural tissue mechanics and stimulate stem cell differentiation for tissue regeneration. Skeleton is a composite comprised of hard mineral nanoparticles (hydroxyapatite, HAP) and organic fiber collagen, and HAP regularly arranged on organic fibers. Because it has complex nanostructures, this high-strength, high toughness can be constituted. In the past, we have tried to simulate these nano structures in the synthetic material. Although some progress has been made in this field, it is difficult to achieve complex nanostructures in synthesis. In material science, mimic biomariations are still a huge challenge in design...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C08G77/392A61L27/02A61L27/18
CPCA61L27/025A61L27/18A61L2430/02C08G77/392C08L83/08
Inventor 周现锋卢迎习李志波芦娜娜
Owner QINGDAO UNIV OF SCI & TECH