Metal bionic bone trabecula for repairing cancellous bone defect and preparing method thereof

Abstract

The invention discloses a metal bionic bone trabecula for repairing a cancellous bone defect and a preparation method thereof. The method includes the steps that with a fast fuse fabrication (FFF) method, metal powder is melted and subjected to electrostatic filament drawing, deposition molding is conducted according to a preset bone trabecula model, and the metal bionic bone trabecula is obtained. According to the preparing method, metal materials are printed into a porous structure similar to the bone trabecula through the FFF technology, the printing precision meets the condition that the filament diameter is 10 microns or below, and true bionics is achieved. Moreover, the adopted metal materials of tantalum, titanium tantalum alloy or titanium tantalum niobium zirconium alloy and the like has biological activities for promoting tissue regeneration, and fully meets clinical use requirements. The bionic bone trabecula prepared with the method can perfectly replace an autologous or allogeneic bone.

Description

technical field [0001] The invention relates to a medical device, in particular to a metal bionic bone trabecular for cancellous bone defect repair and a preparation method thereof. Background technique [0002] Cancellous bone is a porous network structure connected by a large number of irregularly shaped bone trabeculae. Intertwined network of trabeculae (see figure 1 ) actually have certain longitudinal and transverse arrangement rules, which can increase bone strength. These trabecular stress changes can have a pronounced effect on the strength of the bone. The bone trabeculae observed by microscopic means are characterized by external force stimulation: deformation of bone trabeculae, decrease in density, and enlargement of pores in the network structure. When the force reaches a certain level, diffuse fracture will occur, the integrity will be destroyed, and the strength provided by the cancellous bone will decrease, which will lead to a decrease in bone resistance ...

AI Technical Summary

Problems solved by technology

[0005] There are different degrees of defects in autologous or allogeneic bone grafting: 1) Autologous bone grafting will increase the surgical trauma and operation time. The available bone source is limited. The shape and size of the grafted bone are not easy to meet the requirements, and infection may occur in the bone harvesting area , pain and other complications

2) Allogeneic bone transplantation may cause the spread of blood-borne diseases and cause immune reactions to interfere with bone healing and other disadvantages; in addition, allogeneic bone only has osteoconduction but no osteoinductive effect, and fracture healing after transplantation may be relatively slow

[0006] At present, the artificial bone substitutes used clinically for bone defect repair mainly have the following problems: 1) The elastic modulus of the implant does not match that of the bone, and stress shielding is likely to occur after implantation, which accelerates the loss of bone mass and the risk of secondary fractures Increase; 2) The implant does not have the biological function of promoting fracture healing, but only provides a stable environment for fracture healing; 3) Due to the limitation of traditional processing technology, the shape of the filler does not match the defect, which will cause wear and may Cause fracture again; 4) The porosity and irregular shape of porous materials processed by traditional techniques affect the effect of osseointegration

Traditional 3D printing technologies, such as Selective Laser Melting (SLM for short) and Electron Beam Melting (EBM for short), have limited printing accuracy, the highest accuracy can only reach 40 μm, which cannot be satisfied with trabecular bone bionic structure

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