A kind of ultra-strong ferromagnetic fluorescent nanomicelle, preparation method and application
A fluorescent nanometer and magnetic nanoparticle technology, applied in the field of fluorescent nanomaterial preparation, can solve problems such as poor dispersion of magnetic fluorescent nanomicelles, and achieve the effects of high biocompatibility, high thermal conversion efficiency, and long-term stable performance.
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Embodiment 1
[0039] The raw materials needed to prepare the ultra-strong ferromagnetic fluorescent nanomicelles of the present invention include indium phosphide quantum dots and ferric oxide nanoparticles, and the preparation methods are as follows:
[0040] Preparation of indium phosphide quantum dots:
[0041] (1) Nucleus synthesis of indium phosphide quantum dots: indium chloride (Indium chloride), tris (dimethylamino) phosphine (Tris (dimethylamino) phosphine) as raw materials, oleylamine as a solvent, heated to 190°C, and then reacted at 190°C for 30min under nitrogen.
[0042] (2) Shell growth and synthesis of indium phosphide quantum dots: zinc chloride (Zinc chloride), octadecanethiol (1-Octadecanethiol) as raw materials, oleylamine as solvent, heated to 260 ° C under vacuum conditions, and The product in step (1) was injected into the reaction with a glass syringe at 140° C., and then maintained at 260° C. for 30 minutes under nitrogen. Then, after the reaction was completed, i...
Embodiment 2
[0048]In this example, the indium phosphide quantum dots and ferric oxide nanoparticles of Example 1 are used to prepare the super-strong ferromagnetic fluorescent nanomicelle of the present invention, and the process is as follows:
[0049] (1) Mix and disperse 1mg of iron ferric oxide nanoparticles and 3mg of indium phosphide quantum dots in 1mL of chloroform, sonicate the mixture for 5min to disperse evenly, then add 10mL of methanol for centrifugal sedimentation;
[0050] (2) After settling, the supernatant was removed to obtain a precipitate. Under ultrasonic conditions, the precipitate was dissolved in 1 mL of dimethyl sulfoxide, and 20 mg of polyphosphate was added thereto. The rate of addition of polyphosphate was 1 ml / min. , continuous ultrasonication until completely dissolved to obtain a magnetic fluorescent mixture;
[0051] (3) Slowly add the above mixed solution into a glass bottle containing 10 mL of deionized water while ultrasonicating, and use a pipette with ...
Embodiment 3
[0057] In this embodiment, phospholipidated polyethylene glycol polymers are used to replace polyphosphate ester polymers to synthesize magnetic nanomicelles, and other processes are the same as
[0058] Embodiment 2, prepare the transmission electron microscope (TEM) picture of magnetic nano micelles as Figure 5 .
[0059] Such as Figure 5 As shown, in the magnetic nanomicelles synthesized with phospholipidated polyethylene glycol polymers, the ferroferric oxide nanoparticles are still agglomerated together. The free flow of indium phosphide quantum dots cannot make the combination of iron ferric oxide nanoparticles and indium phosphide quantum dots better.
[0060] From Figure 4 and Figure 5 It is found by comparison that the magnetic fluorescent nano-micelles prepared by the present invention have better dispersion and more uniformity.
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