Production technology of glucose sodium chloride injection

Abstract

The invention discloses a production technology of glucose sodium chloride injection. The method comprises the following steps of step I, performing weighing; step II, performing thick blending; stepIII, performing thin blending; step IV, performing washing, stuffing and sealing; step V, performing sterilization; step VI, performing lamp inspection; and step VII, performing packing. According tothe production technology of glucose sodium chloride injection provided by the invention, the quality of the raw materials is strictly controlled, the technological process is adjusted and optimized,and the content of insoluble granules, heavy metal, and bacterial endotoxin in products is obviously reduced. Because nitrogen filling for encapsulation is adopted, the products are good in stability,antioxidants do not need to be added, the safety of the injection is further improved, and the production efficiency of an optimized technology and the qualified rate of finished products are both obviously increased.

Description

technical field [0001] The invention relates to the field of injection production, in particular to a production process for glucose and sodium chloride injection. Background technique [0002] Glucose and Sodium Chloride Injection is widely used clinically to adjust the electrolyte and acid-base balance of human body. It is mainly used for the treatment of dehydration caused by massive bleeding, diarrhea and vomiting. Glucose is one of the main sources of heat in the human body. Sodium and chlorine are important electrolytes in the body, mainly present in extracellular fluid, and play a very important role in maintaining the normal volume and osmotic pressure of blood and extracellular fluid in the human body. [0003] Insoluble particulates in injections refer to particulate impurities generated or mixed in by various means during the production or use of medicines, with particle sizes ranging from 1 to 50 μm and invisible to the naked eye. Because it can flow with the bl...

AI Technical Summary

Problems solved by technology

Boiling water for injection can speed up the dissolution rate of glucose and tinidazole, but due to the high temperature and long retention time, more 5-HMF is produced by the degradation of glucose in a high temperature environment, and there are also residual particles of activated carbon that cannot be completely removed in the subsequent filtration process. Adding solution to adjust the pH is easy to introduce new impurities and particles, and at the same time make the electrolyte composition in the liquid medicine change, etc.

[0007] The existing production process has problems such as slow dissolution rate of raw materials, high content of activated carbon particles and other particles, and high glucose degradation product 5-HMF, which directly affects the production efficiency and quality safety of glucose sodium chloride injection.

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