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Biomedical degradable double-layer stent for nerve repair and preparation method thereof

A biomedical and nerve repair technology, applied in the field of medical supplies, can solve the problems of failure to effectively maintain the space between cells, and achieve the effects of controllable degradation time, simple preparation method, and small pore size

Active Publication Date: 2019-06-14
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patent CN108187147A discloses an electrospun three-layer stent catheter, which has a corresponding response mechanism after conductive electrical stimulation, but when a variety of cells are assembled in the biomaterial, it cannot effectively maintain the position of the intercellular space

Method used

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  • Biomedical degradable double-layer stent for nerve repair and preparation method thereof
  • Biomedical degradable double-layer stent for nerve repair and preparation method thereof
  • Biomedical degradable double-layer stent for nerve repair and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0050] (1) Solution preparation: dissolve poly(ε-caprolactone) with a viscosity-average molecular weight of 100,000 in chloroform, and prepare a concentration of 10% ( w / v ) polymer solution, magnetically stirred for 12 h to obtain a uniform polymer solution;

[0051] (2) Electrospinning: put the polymer solution in the feeding syringe of the electrospinning equipment, adjust the distance between the needle of the syringe and the stationary ground roller to 17 cm; the ambient temperature of spinning is 25 °C; turn on the high voltage Power supply and feeding syringe pump, adjust the voltage to 18 kv, and the feeding speed of the solution is 0.25 mm / min. After working continuously for 10 h, the electrospun poly(ε-caprolactone) fiber membrane is obtained on the rotating grounded roller , the film thickness is 0.20 mm;

[0052] (3) Drying and shaping: The electrospun fiber membrane was placed in a fume hood to evaporate and remove the organic solvent at a temperature of 25 °C a...

Embodiment 2

[0054] (1) Solution preparation: dissolve poly(ε-caprolactone) with a viscosity-average molecular weight of 100,000 in chloroform, and prepare a concentration of 10% ( w / v ) polymer solution, magnetically stirred for 12 h to obtain a uniform polymer solution;

[0055] (2) Electrospinning: Put the polymer solution in the feeding syringe of the electrospinning equipment, adjust the distance between the needle tip of the syringe and the stationary ground roller to 17 cm; the ambient temperature of spinning is 25 °C; turn on the high voltage Power supply and feeding syringe pump, adjust the voltage to 18 kv, and the feeding speed of the solution is 0.25 mm / min. After working continuously for 10 h, the electrospun poly(ε-caprolactone) fiber film is obtained on the rotating grounded roller , the film thickness is 0.20 mm;

[0056] (3) Drying and forming: the electrospun fiber membrane was placed in a fume hood to evaporate and remove the organic solvent at a temperature of 25 °C a...

Embodiment 3

[0059] (1) Solution preparation: dissolve poly(ε-caprolactone) with a viscosity-average molecular weight of 100,000 in chloroform, and prepare a concentration of 10% ( w / v ) polymer solution, magnetically stirred for 12 h to obtain a uniform polymer solution;

[0060] (2) Electrospinning: Put the polymer solution in the feeding syringe of the electrospinning equipment, adjust the distance between the needle tip of the syringe and the stationary ground roller to 17 cm; the ambient temperature of spinning is 25 °C; turn on the high voltage Power supply and feeding syringe pump, adjust the voltage to 18 kv, and the feeding speed of the solution is 0.25 mm / min. After working continuously for 6 hours, the electrospun poly(ε-caprolactone) fiber film is obtained on the rotating grounded roller , the film thickness is 0.11 mm;

[0061] (3) Drying and forming: the electrospun fiber membrane was placed in a fume hood to evaporate and remove the organic solvent at a temperature of 25 °...

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Abstract

The invention relates to a biomedical degradable double-layer stent for nerve repair and a preparation method thereof. The preparation method comprises first dissolving a polyester material in an organic solvent to obtain a polyester polymer solution; performing electrospinning to obtain an electrospinning fiber membrane; drying the electrospinning fiber membrane to obtain a fiber layer of a biodegradable double-layer stent; dissolving a polyvinyl alcohol material in deionized water, adding glycerin and sodium chloride in the heating, stirring and dissolving process, and obtaining a PVA / GI / NaCl polymer solution by ultrasonic processing; adding the PVA / GI / NaCl polymer solution into a glass die, laying the fiber layer on the surface of the solution, standing, freezing and thawing twice, to obtain hydrogel, and removing salt by washing to obtain the biomedical degradable double-layer stent for nerve repair. The biomedical degradable double-layer stent has excellent mechanical properties,controllable degradation time, small pore size and large porosity, a physiological structure of nerve fibers is mimicked, nutrient exchange and cell proliferation are facilitated, and the repair and regeneration against nerve damage are accelerated.

Description

technical field [0001] The invention belongs to the technical field of medical supplies, and in particular relates to a biomedical degradable double-layer bracket for nerve repair and a preparation method thereof. Background technique [0002] The so-called nerve repair regeneration is based on the original nerve anatomy and function, to promote the repair and remodeling of damaged or damaged nerves, rebuild the nerve anatomical projection pathways and circuits, regulate and improve nerve signal conduction, and finally realize the restoration of nerve function (Alessandro Faroni, et al. Neural Regeneration Research 2014, 14: 1341-1346). According to the treatment object, it can be divided into peripheral nerve repair and regeneration and central nerve repair and regeneration. Peripheral nerve injury, especially the repair and reconstruction of long and thick nerve defects, is still a difficult problem in clinical medicine. Autologous nerve transplantation is the classic pr...

Claims

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Application Information

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IPC IPC(8): A61L27/18A61L27/16A61L27/02A61L27/50A61L27/52A61L27/56A61L27/58D01D5/00
Inventor 张进乔紫雯王君曾亮丹
Owner FUZHOU UNIV
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