A drug sustained-release preparation containing dezocine and its preparation method

A sustained-release preparation, the technology of dezocine, applied in the field of medicine, achieves the effect of relieving pain and stabilizing drug release speed
CN110101865BActive Publication Date: 2020-04-10TIANJIN CITY THIRD CENT HOSPITAL
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
TIANJIN CITY THIRD CENT HOSPITAL
Publication Date
2020-04-10

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Abstract

The invention provides a dizocine-containing medicine sustained-release preparation and a preparation method thereof. The dizocine-containing medicine sustained-release preparation is prepared from, by weight, 1-10 parts of dezocine, 1-10 parts of a polylactic acid-hydroxyacetic acid block copolymer, 1-10 parts of a dissolution aiding additive, 1-10 parts of an osmotic pressure regulator, 0.1-0.5part of a pH value stabilizer, 1-5 parts of a wetting agent, 1-10 parts of a freeze-dried powder protectant, 10-50 parts of an organic solvent and 100-1000 parts of water for injection. Compared withan existing dezocine injection reagent, the dezocine is encapsulated in a biocompatible high-molecular polymer, the medicine can be released slowly, the release speed of the medicine is stable, the stable blood concentration can be maintained for 8h or more after single-time administration, the pain of a patient can be effectively relieved, and the dezocine injection reagent can be used for relieving the pain of the patient after the operation.
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Description

technical field

[0001] The invention belongs to the technical field of medicine, and relates to a pharmaceutical composition for anesthesia and analgesic injection and a preparation method thereof, in particular to a drug sustained-release preparation containing dezocine and a preparation method thereof. Background technique

[0002] Dezocine is a mixed agonist-antagonist of opioid receptors, which is a small-molecule highly fat-soluble drug that fully agonizes κ receptors and partially agonizes and partially antagonizes μ receptors. When the blood concentration of dazocine reaches 5-9 μg / L, it will produce analgesic effect, and the analgesic effect is strong, and its analgesic effect is 5-9 times that of pethidine, which is equivalent to morphine. Studies have shown that the spinal cord κ receptor is an important target for dezocine to produce analgesic effect. Dezocine absorbs quickly in the body, distributes rapidly, and has a long half-life, so its analgesic effect has ...

Claims

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