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3D printed controllable porous hydroxyapatite bioceramic stent and preparation method thereof

A technology of porous hydroxyapatite and hydroxyapatite, applied in bone implants, additive processing, etc., can solve the problems of low efficiency and achieve low viscosity, good fluidity, and high precision

Inactive Publication Date: 2019-09-24
SHANGHAI INST OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For traditional porous materials, 3D printing technology is used to process and form, but the specific surface area limits the porosity under the relative volume, resulting in low efficiency (Chinese patents CN 109227877A, 107998455A, CN 109650909A), the researchers proposed "three-period minimization Surface" (TPMS) topology method, the bionic structure topologically formed by this method has more advantages, such as perfect pore interconnection, high surface area to volume ratio, easy control of pore structure, high strength and stiffness, etc., light weight Porous materials have broad application prospects in bone engineering due to their high specific strength and high energy absorption efficiency.

Method used

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  • 3D printed controllable porous hydroxyapatite bioceramic stent and preparation method thereof
  • 3D printed controllable porous hydroxyapatite bioceramic stent and preparation method thereof
  • 3D printed controllable porous hydroxyapatite bioceramic stent and preparation method thereof

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] 1. Add the hydroxyapatite powder to the premix of resin, dispersant, defoamer and other additives until the powder reaches 40vol%, use zirconia grinding balls with a diameter of 3-5mm, the ball-to-material ratio is 1:2, and the rotation speed 100r / min, ball milling for 4h to prepare hydroxyapatite slurry for photocuring printing.

[0031] 2. Use the Magics three-dimensional mapping software to draw a p-cell model with a bionic TPMS structure and a theoretical porosity of 85%, such as figure 2 As shown in A.

[0032] 3. Put the hydroxyapatite ceramic-resin slurry under the DLP light curing machine for printing, the wavelength is 405nm, and the light intensity is 10000μw / cm 2， The thickness of the printing layer is 50 μm, the exposure time of the first layer is 3s, and the exposure time of the single layer is 1s, and the printing is accumulated and formed layer by layer.

[0033] 4. Put the printed ceramic green body into an ordinary pressureless muffle furnace for deg...

Embodiment 2

[0036] 1. Add the hydroxyapatite powder to the premix of resin, dispersant, defoamer and other additives until the powder reaches 40vol%, use zirconia grinding balls with a diameter of 3-5mm, the ball-to-material ratio is 1:2.5, and the speed 110r / min, ball milling for 6h to prepare hydroxyapatite slurry for photocuring printing.

[0037] 2. Use the Magics 3D mapping software to draw the S-14 model with a bionic TPMS structure and a theoretical porosity of 85%, such as figure 2 Shown in B.

[0038] 3. Put the hydroxyapatite ceramic-resin slurry under the DLP light curing machine for printing, the wavelength is 405nm, and the light intensity is 10000μw / cm 2，The thickness of the printing layer is 50 μm, the exposure time of the first layer is 5s, and the exposure time of the single layer is 1s, and the printing is accumulated layer by layer.

[0039] 4. Put the printed ceramic green body into an ordinary pressureless muffle furnace for degreasing and sintering. The temperatur...

Embodiment 3

[0042] 1. Add the hydroxyapatite powder to the premix of resin, dispersant, defoamer and other additives until the powder reaches 45vol%, use zirconia grinding balls with a diameter of 3-5mm, the ball-to-material ratio is 1:3, and the rotation speed 120r / min, ball milling for 6h to prepare hydroxyapatite slurry for photocuring printing.

[0043] 2. Use Solidworks three-dimensional drawing software to draw a G-yroid model with a bionic TPMS structure and a theoretical porosity of 90%, such as figure 2 C shows.

[0044] 3. Put the hydroxyapatite ceramic-resin slurry under the DLP light curing machine for printing, the wavelength is 405nm, and the light intensity is 10000μw / cm 2， The thickness of the printing layer is 50 μm, the exposure time of the first layer is 2s, and the exposure time of the single layer is 2s, and the printing is accumulated and formed layer by layer.

[0045] 4. Put the printed ceramic green body into an ordinary pressureless muffle furnace for degreasi...

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Abstract

The invention relates to a 3D printed controllable porous hydroxyapatite bioceramic stent and a preparation method thereof. The method comprises the steps that hydroxyapatite paste used for a hydroxyapatite bone tissue bioceramic stent is prepared; a TPMS porous structure is established by using three-dimensional modeling software, and a model structure is adjusted to obtain a TPMS porous structure model with the porosity of 60%-95%, and is saved in an STL format; an STL format model with macroscopic pores is introduced into a photocurable printer; photocuring printing parameters are adjusted, so that the hydroxyapatite paste is stacked layer by layer for superposition moulding to obtain a bioceramic stent biscuit; the bioceramic stent biscuit is put into an ultraviolet curing box for secondary curing, and is placed in a muffle sintering furnace for degreasing and calcination to obtain the porous hydroxyapatite bone tissue bioceramic stent with high density. The prepared porous hydroxyapatite bone tissue stent has a pore structure with high connectivity, has inorganic components consistent with the inorganic components of the human bone, and has excellent biological properties.

Description

technical field [0001] The invention relates to a bioceramic support, in particular to a method for preparing a controllable porous hydroxyapatite bone tissue engineering bioceramic support based on 3D printing technology. Background technique [0002] Large bone defects caused by various reasons such as trauma, infection, tumor, surgery, bone aging, congenital deformity, etc. usually require bone grafting for treatment. At present, bone tissue engineering technology overcomes the shortcomings of traditional bone defect transplantation technology, and provides a new option for clinical bone repair treatment. As a new processing and molding technology, 3D printing can meet the needs of micro and macro structures at the same time, has high molding precision, avoids complicated mold production technology, and realizes personalized customization, which has great advantages in bone tissue engineering. [0003] Hydroxyapatite (hydroxyapatite, abbreviated as HA or HAp) is not only...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C04B35/447C04B35/622A61F2/28B33Y10/00B33Y70/00
CPCA61F2/28B33Y10/00B33Y70/00C04B35/447C04B35/622C04B2235/6026C04B2235/656C04B2235/6562C04B2235/6567
Inventor 姚永霞王操沈民浩赵喆
Owner SHANGHAI INST OF TECH
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