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Antitoxic antibacterial complex agent for resistance to HPV virus infection and preparation method of phase inversion gel of complex agent

A compound agent and phase inversion technology, applied in the field of medicine, can solve the problems of unfavorable treatment, lack of protection of wound surface, easy recurrence of infection, etc., achieve the effect of repairing damaged mucosal tissue, good clinical application prospects, and improving treatment effect

Pending Publication Date: 2019-10-01
湖北亿彤实业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

During the treatment, there will be a physiological hyporesponse period, or side effects such as temporary leukopenia, thrombocytopenia, and mild liver abnormalities, which are not conducive to treatment, and the effect is not very satisfactory
The invention patent application number is 03111091.6, and the name is "Anti-Human Papilloma Virus Ointment". It introduces an ointment for the treatment of HPV virus and a drug for smearing, but because it contains toxic substances such as arsenic and lead red, it has side effects. Large, easy poisoning risk
The patent application number is 201410541305.3, and the title is "Pokeweed Antiviral Protein Freeze-dried Powder Compound and Its Preparation Method", which discloses a compound agent. Not only the use process is cumbersome, but also the liquid is easy to lose, the retention time in the female reproductive tract is short, the drug penetration is poor, the wound is not protected, and it is difficult to achieve the intended purpose
The patent application number is 201610694240.5, and the name is "An Anti-Human Papillomavirus Gel and Its Preparation Method" discloses a drug gel. Although the residence time of this semi-solid gel is ideal, it has a certain effect on the wound surface. Protective effect, but the diffusion ability is weak, and the drug cannot guarantee to reach the dead corners (folds, fissures, deep wounds) in the female reproductive tract, resulting in incomplete drug coverage and easy recurrence of infection

Method used

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  • Antitoxic antibacterial complex agent for resistance to HPV virus infection and preparation method of phase inversion gel of complex agent
  • Antitoxic antibacterial complex agent for resistance to HPV virus infection and preparation method of phase inversion gel of complex agent

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preparation example Construction

[0040] The preparation method of described Quercus Iberia water extract is: get Quercus Iberia leaf and pulverize into 80 order powders and add 10 times of volume water to decoct respectively 2 times, each time 45 minutes, concentrating under reduced pressure after merging filtrate, drying After that, the aqueous extract of Quercus iberia was obtained.

[0041] The preparation method of the turmeric alcohol extract is as follows: take the turmeric decoction pieces and grind them into 50 mesh powders, add 10 times the volume of ethanol, heat and reflux for 1 hour, filter while it is hot, repeat the aforementioned operations for the filter residue, combine the two filtrates, and concentrate to No alcohol smell, the turmeric alcohol extract is obtained after drying.

Embodiment 1

[0043] 1. Take 8 parts of Inonotus obliquus intracellular polysaccharide (commercially available product), 4 parts of Quercus Iberia water extract, 0.25 part of chlorhexidine gluconate, dissolve with 20 parts of purified water and set aside;

[0044] 2. Get 2 parts of ethyl acetate extract of Inonotus obliquus and 2.75 parts of turmeric alcohol extract, after dissolving with 5 parts of 95% ethanol by volume fraction, set aside;

[0045] 3. Take 16 parts of Poloxamer 407 and 2 parts of Poloxamer 188, add them to 40 parts of purified water, heat to above 55°C, stir well until dissolved, then slowly add the solutions of the above step 1 and step 2 respectively, and stir After uniformity, cool to room temperature to obtain the phase-inversion gel of the antidote and antibacterial agent mixture.

Embodiment 2

[0047] 1. Get 4 parts of intracellular polysaccharide of Inonotus obliquus, 3 parts of exopolysaccharide of Inonotus obliquus, 5 parts of Quercus iberica water extract, 0.15 part of chlorhexidine gluconate, dissolve with 20 parts of purified water and set aside;

[0048] 2. Get 2.85 parts of ethyl acetate extract of Inonotus obliquus and 2 parts of turmeric alcohol extract, after dissolving with 5 parts of 95% ethanol by volume fraction, set aside;

[0049] 3. Take 15 parts of Poloxamer 407, add it to 43 parts of purified water, heat to above 55°C, stir well until dissolved, then slowly add the solution of the above step 1 and step 2, stir evenly and cool to room temperature to obtain Anti-toxin and antibacterial agent mixture phase inversion gel.

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Abstract

The invention discloses an antitoxic antibacterial complex agent for resistance to HPV virus infection and a preparation method of phase inversion gel of the complex agent. The antitoxic antibacterialcomplex agent comprises chaga mushroom polysaccharide, a chaga mushroom ethyl acetate extract, an Iberian oak water extract, a radix curcumae alcohol extract, chlorhexidine gluconate and a high polymer carrier. The preparation method comprises the steps that the high polymer carrier is heated and dissolved in water of 50 DEG or above, the chaga mushroom polysaccharide, the chaga mushroom ethyl acetate extract, the Iberian oak water extract, the radix curcumae alcohol extract and the chlorhexidine gluconate are separately dissolved in a proper amount of water or ethyl alcohol and then added tothe high polymer carrier, even mixing is conducted, and through cooling, the flow-state gel is obtained. The invention provides a drug and the preparation method of the phase inversion gel of the drug. The drug can effectively inhibit HPV viruses and stop the HPV viruses from entering cells through cell membrane fusion, enhances the cell immune activity, repairs the damaged mucosa of the genitaltract of women and has an obvious treatment effect on the diseases, such as cervical epithelia cell neoplasia (CIN) and cervical erosion, caused by HPV virus infection.

Description

technical field [0001] The invention relates to the field of medicine, and more specifically, relates to the preparation method of the antiviral and antibacterial compound agent and its phase inversion gel, as well as its application in the treatment and prevention of HPV infection and related diseases. Background technique [0002] With the continuous deepening of human understanding of diseases related to HPV virus infection, HPV virus DNA sequence analysis technology has become the main method and basis for HPV virus typing. At present, there are more than 100 types of HPV identified, about 35 types can infect the female reproductive tract, and about 20 types are related to tumors. According to different types of HPV and the risk of tumor occurrence, HPV is divided into low-risk types and high-risk types. Among them, 15 types were identified as high-risk HPV viruses, which were related to the occurrence of cervical cancer and cervical intraepithelial lesions (CINⅡ / Ⅲ), es...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/9066A61K9/06A61P15/00A61P17/12A61P31/20A61P35/00A61K31/715A61K31/191A61K31/155
CPCA61K9/0034A61K9/06A61K31/155A61K31/19A61K31/715A61K36/07A61K36/49A61K36/9066A61K47/26A61P15/00A61P17/12A61P31/20A61P35/00A61K2300/00
Inventor 黄仁杰约翰·古斯塔夫·卡尔松杰森·陈
Owner 湖北亿彤实业有限公司
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