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Sr-GO/PCL composite bone scaffold and preparation method thereof

A bone scaffold and composite particle technology, which is applied in the fields of pharmaceutical formulation, processing and manufacturing, and medical science, can solve problems such as poor hydrophilicity, poor dispersion, and low mechanical strength, and achieve improved mechanical strength and cell adhesion. Excellent mechanical strength properties and hydrophilic properties, the effect of accelerating osteoblast differentiation

Inactive Publication Date: 2019-10-15
JIANGXI UNIV OF SCI & TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] In view of the low mechanical strength, poor hydrophilicity and low biological activity of the polycaprolactone bone scaffold in the prior art, graphene oxide and strontium nanoparticles are introduced into the polycaprolactone bone scaffold material as the second phase and have poor dispersion, which is easy to Reunion and other issues

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0044] (1) Weigh 0.025 mg of graphene oxide powder with an electronic balance, add it into 50 mL of ultrapure water, and form a suspension with a concentration of 0.5 mg / mL under the action of ultrasonic stirring.

[0045] (2) 100mL containing Sr 2+ A solution with a concentration of 10mM (prepared by adding strontium chloride to depurified water) was added dropwise to 100mL graphene oxide solution under stirring, and the stirring speed was 2000r / min. React for 72 hours, then use ultrapure water to repeatedly wash the filtered composite powder, and centrifuge it on a centrifugal device with a rotation speed of 10,000rpm for 15min, and then dry it at 60°C for 24h to obtain the Sr-GO composite powder;

[0046] (3) Weigh 9.95g of PCL powder with a particle size of 40 μm, add it to a three-necked flask filled with anhydrous ethanol solution, and realize its pre-dispersion by mechanical stirring and ultrasonic dispersion;

[0047] (4) Use an electronic balance to weigh 0.05g of Sr...

Embodiment 2

[0051] (1) Weigh 0.025 mg of graphene oxide powder with an electronic balance, add it into 50 mL of ultrapure water, and form a suspension with a concentration of 0.5 mg / mL under the action of ultrasonic stirring.

[0052] (2) 100mL containing Sr 2+ A solution with a concentration of 10mM (prepared by adding strontium chloride to depurified water) was added dropwise to 100mL graphene oxide solution under stirring, and the stirring speed was 2000r / min. React for 72 hours, then use ultrapure water to repeatedly wash the filtered composite powder, and centrifuge it on a centrifugal device with a rotation speed of 10,000rpm for 15min, and then dry it at 60°C for 24h to obtain the Sr-GO composite powder;

[0053] (3) Weigh 9.9 g of PCL powder with a particle size of 40 μm, add it to a three-necked flask filled with anhydrous ethanol solution, and realize its pre-dispersion by mechanical stirring and ultrasonic dispersion;

[0054] (4) Use an electronic balance to weigh 0.1g of Sr-...

Embodiment 3

[0058] (1) Weigh 0.025 mg of graphene oxide powder with an electronic balance, add it into 50 mL of ultrapure water, and form a suspension with a concentration of 0.5 mg / mL under the action of ultrasonic stirring.

[0059] (2) 100mL containing Sr 2+ A solution with a concentration of 10mM (prepared by adding strontium chloride to depurified water) was added dropwise to 100mL graphene oxide solution under stirring, and the stirring speed was 2000r / min. React for 72 hours, then use ultrapure water to repeatedly wash the filtered composite powder, and centrifuge it on a centrifugal device with a rotation speed of 10,000rpm for 15min, and then dry it at 60°C for 24h to obtain the Sr-GO composite powder;

[0060] (3) Weigh 9.5g of PCL powder with a particle size of 40 μm, add it to a three-necked flask filled with anhydrous ethanol solution, and realize its pre-dispersion by mechanical stirring and ultrasonic dispersion;

[0061] (4) Use an electronic balance to weigh 0.5g of Sr-G...

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PUM

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Abstract

The invention provides a Sr-GO / PCL composite bone scaffold and a preparation method thereof. The Sr-GO / PCL composite bone scaffold is composed of a PCL matrix and Sr-GO composite particles dispersed in the PCL matrix. The preparation method comprises the steps that a Sr<2+>-containing solution is added dropwise to a GO-containing solution under the action of stirring, then a static reaction is performed on the mixed solution at a room temperature, an oxygen-containing functional group on the surface of GO attaches and deposits Sr<2+> in an anchor solution to grow to form ruthenium nanoparticles, and Sr-GO composite particles are obtained; PCL powder and the Sr-GO composite particles are mixed by a liquid phase, then solid-liquid separation is carried out to obtain Sr-GO / PCL composite powder; and Sr-GO / PCL composite powder is subjected to selective laser sintering to obtain the Sr-GO / PCL composite scaffold. The preparation method utilizes GO as a nucleation matrix and carrier of Sr nanoparticles, the dispersion of GO and Sr nanoparticles in the PCL matrix is synergistically promoted, and the composite scaffold is endowed with excellent biological activity, hydrophilicity and mechanical properties; and meanwhile, PCL degradation in the body is used for achieving slow controlled release of Sr<2+> to achieve the purposes of promotion of vascularization, mineralization and osteogenesis.

Description

technical field [0001] The invention relates to a preparation method of a Sr-GO / PCL composite bone support, belonging to the technical field of artificial bone support materials. Background technique [0002] Polycaprolactone (PCL), as a synthetic polymer material, has great potential in the field of biomedicine because of its good biocompatibility, biodegradability and low melting point (59-64°C). application potential. Especially after the material is certified by the US Food and Drug Administration (FDA) and the European Consolidation (CE) as being applicable to tissue engineering, the products manufactured by it are more likely to be marketed. However, PCL itself has no biological activity and poor hydrophilicity, which leads to its low affinity to cells. At the same time, the mechanical strength of PCL is also low, which is difficult to meet the use requirements of compact bone. The above problems limit its application in bone transplantation. application on things. ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/44A61L27/54A61L27/58B29B7/00B29C64/153B33Y10/00
CPCA61L27/443A61L27/446A61L27/54A61L27/58A61L2300/102A61L2300/412A61L2300/604A61L2400/12A61L2430/02B29B7/002B33Y10/00B29C64/153C08L67/04
Inventor 戚方伟帅词俊彭淑平杨友文杨文静
Owner JIANGXI UNIV OF SCI & TECH