A kind of method of cumene compound selective oxidation

A compound, cumene technology, applied in the field of organic chemical industry and fine organic synthesis, can solve the problems of reducing environmental compatibility and biocompatibility, product transition metal pollution, safety reduction, etc., achieving novel reaction methods, avoiding toxic and harmful The use of organic solvents, the effect of convenient operation
CN110423185BActive Publication Date: 2022-03-18ZHEJIANG UNIV OF TECH
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
ZHEJIANG UNIV OF TECH
Publication Date
2022-03-18

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Abstract

A method for selective oxidation of cumene compound, said method is: placing cumene compound shown in formula (I), iron porphyrin catalyst, oxidant, and dispersant in a ball milling tank, sealing the ball milling tank, At room temperature, ball mill at a speed of 100 to 800 rpm for 3 to 24 hours. During the ball milling process, stop the ball milling once every 1 to 3 hours to release the gas in the ball mill tank. After the reaction is completed, the reaction mixture is post-treated to obtain the product of formula (II). Shows 2-phenyl-2-propanol compounds; the present invention realizes the oxidative transformation of cumene and its derivatives by solid-phase ball milling, the reaction mode is novel, the operation is convenient, and the energy consumption is low; no organic solvent is needed, and poisonous The use of harmful organic solvents is environmentally friendly; the peroxide content is low and the safety factor is high; the selectivity of 2-phenyl-2-propanol and its derivatives is high, which is in line with the current green chemical process, environmental compatibility chemical process, and biocompatible Social needs of sexual chemical process.
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Description

(1) Technical field

[0001] The invention relates to a new method for preparing 2-phenyl-2-propanol compounds through selective oxidation of cumene compounds, which belongs to the field of organic chemical industry and fine organic synthesis. (2) Background technology

[0002] 2-Phenyl-2-propanol and its derivatives are an important class of fine chemical intermediates, widely used in the synthesis of fine chemical products such as medicines, pesticides, dyes, spices (WO 2017068412; WO 2015135094; Chemical Engineering Science 2018, 177:391-398; ChemCatChem 2014, 6:555-560). At present, the synthesis of 2-phenyl-2-propanol and its derivatives is mainly based on cumene and its derivatives as raw materials, and oxygen is used as an oxidant, and it is prepared by oxidation reaction (ACS Sustainable Chemistry & Engineering 2019,7:7708- 7715; ChemCatChem2018, 10:198-205). In this oxidation process, since the intermediate product 2-phenyl-2-propyl hydroperoxide and its derivatives...

Claims

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