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Nitrogen doped graphene quantum dots as well as preparation method and application thereof

A technology of graphene quantum dots and nitrogen doping, which is applied in the field of fluorescence sensing, can solve the problems of high yield and gram-level preparation methods of undoped GQDs, and achieve obvious selective recognition ability, high quantum yield, and product The effect of uniform structure and size

Inactive Publication Date: 2019-11-26
广西医科大学附属肿瘤医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] However, the facile and gram-scale synthesis of doped GQDs with specific metal ion selectivity remains challenging.
There is currently no high-yield, gram-scale preparation of doped GQDs with mercury ion selectivity

Method used

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  • Nitrogen doped graphene quantum dots as well as preparation method and application thereof
  • Nitrogen doped graphene quantum dots as well as preparation method and application thereof
  • Nitrogen doped graphene quantum dots as well as preparation method and application thereof

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Embodiment 1

[0060] 1. Hydrothermal synthesis of nitrogen-doped graphene quantum dots

[0061] After hydrothermal synthesis in a mixed aqueous solution of 1,3,6-trinitropyrene, tryptophan and sodium hydroxide for a certain period of time, the resulting solution was purified by dialysis. Among them, the concentration of 1,3,6-trinitropyrene is 6mmol / L, the concentration of tryptophan is 15mmol / L, the concentration of sodium hydroxide is 0.15mol / L, the hydrothermal reaction temperature is 200℃, and the hydrothermal reaction The time is 10h. After the reaction product was fully dialyzed by a dialysis bag with a molecular weight cut-off of 1000 Da, the solution in the dialysis bag was fully dialyzed again by a dialysis bag with a molecular weight cut-off of 3500 Da, and the solution outside the dialysis bag was the nitrogen-doped graphene quantum dot solution.

[0062] 2. Characterization and detection

[0063] Nitrogen-doped graphene quantum dots in specific example 1 are tested and charact...

Embodiment 2

[0077] 1. Hydrothermal synthesis of nitrogen-doped graphene quantum dots

[0078] After hydrothermal synthesis in a mixed aqueous solution of 1,3,6-trinitropyrene, tryptophan and sodium hydroxide for a certain period of time, the resulting solution is purified by dialysis and further freeze-dried to obtain a graphene quantum dot solid. Among them, the concentration of 1,3,6-trinitropyrene is 4mmol / L, the concentration of tryptophan is 20mmol / L, the concentration of sodium hydroxide is 0.15mol / L, the hydrothermal reaction temperature is 180℃, and the hydrothermal reaction The time is 6h. After the reaction product was fully dialyzed by a dialysis bag with a molecular weight cut-off of 1000 Da, the solution in the dialysis bag was fully dialyzed again by a dialysis bag with a molecular weight cut-off of 3500 Da, and the solution outside the dialysis bag was the nitrogen-doped graphene quantum dot solution.

[0079] 2. Characterization and detection

[0080] Nitrogen-doped grap...

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Abstract

The invention discloses nitrogen doped graphene quantum dots as well as a preparation method and application thereof in detecting mercury ions and cysteine and belongs to the technical field of fluorescence sensation. The preparation method comprises the following steps: dissolving a carbon source compound and a nitrogen source compound into water so as to obtain a mixed water solution, and performing a hydrothermal reaction under an alkali condition, so as to obtain the nitrogen doped graphene quantum dots, wherein the carbon source compound is 1,3,6-trinitropyrene; the nitrogen source compound is tryptophan; and the alkali condition is adjusted by using sodium hydroxide. The preparation method is high in yield, and gram-grade synthesis can be achieved at one time. Due to doping of high-content nitrogen atoms, the prepared nitrogen doped graphene quantum dots have glue fluorescence and have unique mercury ion selectivity. On the basis of quenching of mercury ions upon fluorescence ofthe nitrogen doped graphene quantum dots, sensitive fluorescence detection on the mercury ions can be achieved, and the detection limit is low. As the fluorescence quenched by the mercury ions can berecovered by using the cysteine, fluorescence detection on the cysteine can be achieved with the combination of the nitrogen doped graphene quantum dots and the cysteine.

Description

technical field [0001] The invention relates to the technical field of fluorescence sensing, in particular to a nitrogen-doped graphene quantum dot, a preparation method thereof, and an application in fluorescence detection of mercury ions and cysteine. Background technique [0002] Small molecules play crucial roles in various physiological and pathological processes. For example, mercury ions (Hg 2+ ) is one of the most toxic pollutants, which poses a great threat to the environment and human health. It can be converted into more toxic methylmercury through microbial methylation, and then accumulate in organisms through the food chain. Even at low concentrations of Hg intake 2+ It can also damage the nervous, endocrine and other systems, which can lead to many fatal diseases, such as headaches, kidney failure, mental loss, etc. As one of the essential amino acids in the human body, cysteine ​​has important physiological functions in nerve tissue, metabolism and detoxifi...

Claims

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Application Information

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IPC IPC(8): C09K11/65B82Y20/00B82Y30/00G01N21/64
CPCB82Y20/00B82Y30/00C09K11/65G01N21/6428G01N2021/6432
Inventor 唐卫中罗涛陈洁刘军杰毛宇昂赵昌
Owner 广西医科大学附属肿瘤医院
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