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A preparation method of zinc or zinc alloy or its composite material tissue engineering scaffold

A technology of tissue engineering scaffolds and composite materials, which is applied in the field of medical material preparation, can solve the problems of difficult preparation, high safety factor requirements, high metal 3D printing costs, etc., and achieves a wide range of pore sizes, uniform distribution of pores, and is conducive to repair Effect

Inactive Publication Date: 2021-03-30
TIANJIN UNIVERSITY OF TECHNOLOGY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For example, zinc alloy and magnesium alloy are suitable for metal 3D printing powder materials, which are difficult to prepare, and at the same time, the safety factor requirements are relatively high during the preparation and storage process, which is prone to danger.
During the printing process, the high-temperature viscosity of zinc alloy will cause the volatilized alloy powder to adhere to the inner wall of the bracket and the surface of the hole structure, resulting in distortion of the final printed structure
At the same time, the high cost of metal 3D printing also limits the promotion of its preparation process

Method used

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  • A preparation method of zinc or zinc alloy or its composite material tissue engineering scaffold
  • A preparation method of zinc or zinc alloy or its composite material tissue engineering scaffold

Examples

Experimental program
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Effect test

Embodiment 1

[0027] The invention discloses a preparation method of a pure zinc tissue engineering scaffold, wherein the base material of the tissue engineering scaffold is pure zinc. The polylactic acid model was prepared by FDM3D printing, and then the pure zinc tissue engineering scaffold was prepared by percolation casting after preparing gypsum and salt mold. The steps are as follows:

[0028] 1) Adjust the parameter C in the P function: A=cos(x)+cos(y)+cos(z)+C to -0.5 to obtain a monomer model with a porosity of 64% and a pore size of 1174 μm. Import UG software, stack and cut regularly to obtain a cylindrical porous scaffold body with a diameter of 60mm and a height of 40mm.

[0029] 2) Import the designed stent model into the slicing software corresponding to the FDM3D printer to obtain the printer identification format file. Set the printing temperature and input it into the printer to prepare the polylactic acid porous scaffold. After obtaining the stent body, remove the base...

Embodiment 2

[0035] The invention discloses a preparation method of a pure zinc tissue engineering scaffold, wherein the base material of the tissue engineering scaffold is pure zinc. The polylactic acid model was prepared by FDM3D printing, and then the pure zinc tissue engineering scaffold was prepared by percolation casting after preparing gypsum and salt mold. The steps are as follows:

[0036] 1) Adjust the parameter C in the P function: A=cos(x)+cos(y)+cos(z)+C to 0.25 to obtain a monomer model with a porosity of 42% and a pore size of 645 μm, and import the monomer into UG software, after regular stacking and cutting, a cylindrical porous scaffold body with a diameter of 60mm and a height of 40mm is obtained.

[0037] 2) Import the designed stent model into the slicing software corresponding to the FDM3D printer to obtain the printer identification format file. Set the printing temperature and input it into the printer to prepare the polylactic acid porous scaffold. After the ste...

Embodiment 3

[0043] The invention discloses a preparation method of a pure zinc tissue engineering scaffold, wherein the base material of the tissue engineering scaffold is pure zinc. The polylactic acid model was prepared by FDM3D printing, and then the pure zinc tissue engineering scaffold was prepared by percolation casting after preparing gypsum and salt mold. The steps are as follows:

[0044] 1) Adjust the parameter C in the P function: A=cos(x)+cos(y)+cos(z)+C to 0.5 to obtain a monomer model with a porosity of 35% and a pore size of 240 μm, and import the monomer into UG software, after regular stacking and cutting, a cylindrical porous scaffold body with a diameter of 60mm and a height of 40mm is obtained.

[0045] 2) Import the designed stent model into the slicing software corresponding to the FDM3D printer to obtain the printer identification format file. Set the printing temperature and input it into the printer to prepare the polylactic acid porous scaffold. After the sten...

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Abstract

The invention provides a manufacturing method of a zinc or zinc alloy or zinc alloy composite material tissue engineering support. The method designs and manufactures the multi-hole zinc or zinc alloyor zinc alloy composite material tissue engineering support by means of combination with the 3D printing technology, mould turnover casting and an air compressing seepage method. The method solves the problem that current 3D printing cannot directly manufacture the zinc or zinc alloy or zinc alloy composite material multi-hole support, and alloy 3D printing manufacturing of zinc, zinc alloys andthe like with the low melting point, the low boiling point and high high-temperature volatility can be achieved indirectly. The method comprises the following specific steps that 1, hole parameters are designed through P function, and STL data are obtained through UG modeling; 2, the data are imported into corresponding software of a 3D printer, and printing is carried out to obtain a polylactic acid support; 3, prepared gypsum and salt composite slurry are poured, dried and sintered to obtain a mould turnover body; 4, penetrating of the hole diameter of the mould turnover body is carried out,and the surface is trimmed; 5, the air compressing seepage method is adopted for seeping molten metal in the mould turnover body; and 6, salt is washed away ultrasonically, gypsum mould turning overis carried out, and the multi-hole zinc or zinc alloy or zinc alloy composite material tissue engineering support is obtained.

Description

technical field [0001] The invention belongs to the technical field of medical material preparation, and relates to a preparation method of a bone tissue engineering support, in particular to a preparation method of a degradable zinc or zinc alloy or composite material tissue engineering support capable of designing pore structure and pore size. Background technique [0002] In recent years, with the rapid development of medical bone tissue engineering, porous metal scaffolds that are biodegradable in physiological environments have attracted considerable attention in bone tissue engineering applications. Degradable metal scaffolds not only have excellent mechanical properties, but also can provide a good growth and reproduction space for human tissue cells. Its suitable corrosion degradation rate and good biological safety allow degradable metal stents to gradually degrade in the body while meeting service requirements, and finally be absorbed and metabolized by the human b...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B22D23/04B22C7/02C22C18/00C22C18/02C22C32/00A61L27/58A61L27/50A61L27/04A61L27/12B33Y10/00
CPCA61L27/047A61L27/12A61L27/50A61L27/58A61L2300/112A61L2300/412A61L2430/02B22C7/02B22D23/04B33Y10/00C22C18/00C22C18/02C22C32/0089
Inventor 刘德宝潘超陆国梁苏越
Owner TIANJIN UNIVERSITY OF TECHNOLOGY
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