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Drug-loaded compound microsphere as well as preparation and application thereof

A compound and microsphere technology, applied in application, drug combination, antibacterial drugs, etc., can solve the problems of low utilization rate of antibiotics and large residues, and achieve the effects of controlling antibiotic pollution, low cost, and wide range of raw materials

Pending Publication Date: 2019-12-13
ZHEJIANG UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The purpose of the present invention is to provide a method for preparing drug-loaded bait microspheres that can be used for antibiotic pollution control in freshwater aquaculture. The drug-loaded microspheres prepared by this method can solve the problems of low utilization rate and large residual amount of antibiotics in freshwater aquaculture

Method used

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  • Drug-loaded compound microsphere as well as preparation and application thereof
  • Drug-loaded compound microsphere as well as preparation and application thereof
  • Drug-loaded compound microsphere as well as preparation and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Embodiment 1 drug-loaded composite microspheres and fish kinetics test

[0020] 1. The quality formula of drug-loaded composite microspheres: 2 parts of starch, 0.6 parts of vanillin, 2 parts of sodium alginate, 0.4 parts of tetracycline hydrochloride, and 3 parts of calcium chloride.

[0021] 2. Preparation of drug-loaded composite microspheres:

[0022] (1) Heat 200mL of deionized water to 50°C, stir and add 2g of starch to form a uniform mixture, then add 0.6g of flavor additive vanillin, after the vanillin is completely dissolved, slowly and evenly add 2g of sodium alginate, and fully dissolve Add 0.4g tetracycline hydrochloride to completely disperse tetracycline hydrochloride in the mixed solution to obtain mixed colloids;

[0023] (2) Under stirring, use a peristaltic pump to squeeze the mixed colloid into 200mL of 3g (mass concentration: 1.5%) CaCl at a rate of 200mL / h through a catheter with a needle. 2 After filtering, 10 g of the filter cake was added to 20...

Embodiment 2

[0032] Embodiment 2 drug-loaded composite microspheres and fish kinetics test

[0033] 1. The quality formula of drug-loaded composite microspheres: 2 parts of starch, 0.6 parts of taurine, 3 parts of sodium alginate, 0.5 parts of sulfadiazine, and 4.5 parts of calcium chloride.

[0034] 2. Preparation of drug-loaded composite microspheres:

[0035] (1) Heat 200mL of deionized water to 50°C, stir and add 2g of starch to form a uniform mixture, then add 0.2g of flavor additive taurine, after the taurine is completely dissolved, add 3g of sodium alginate to it, fully dissolve and evenly Then add 0.5g sulfadiazine to completely disperse sulfadiazine in the mixed solution to obtain mixed colloids;

[0036] (2) Under stirring, use a peristaltic pump to squeeze the mixed colloid into a 300mL solution containing 4.5g (mass concentration 1.5%) CaCl through a catheter with a needle at a rate of 300mL / h. 2 Take 10g of the filter cake and add it to 200mL of 0.9% sodium chloride aqueous...

Embodiment 3

[0045] Embodiment 3 drug-loaded composite microspheres and fish kinetics test

[0046] 1. The quality formula of drug-loaded composite microspheres: 1 part of starch, 0.5 part of sweetener, 3 parts of sodium alginate, 1 part of tetracycline hydrochloride, and 4 parts of calcium chloride.

[0047] 2. Preparation of drug-loaded composite microspheres:

[0048] (1) Heat 200mL of deionized water to 50°C, stir and add 1g of starch to form a uniform mixture, add 0.5g of flavor additive vanillin, and slowly and evenly add 3g of sodium alginate after the vanillin is completely dissolved, and fully dissolve Add 1g of tetracycline hydrochloride to completely disperse the tetracycline hydrochloride in the mixed solution to obtain mixed colloids;

[0049] (2) Under stirring, use a peristaltic pump to squeeze the mixed colloid into 200mL of 4g (mass concentration 2%) CaCl 2 In the water, filter, take 10g of the filter cake and add it to 200mL of 0.9% sodium chloride aqueous solution with...

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Abstract

The invention discloses a drug-loaded compound microsphere as well as a preparation and an application thereof. The drug-loaded compound microsphere is prepared from the following raw materials in parts by mass: 1-2 parts of starch, 0.4-0.6 parts of a flavoring agent, 2-3 parts of sodium alginate, 0.4-4 parts of antibiotics and 2-5 parts of calcium chloride. According to the invention, an antibiotic use mode is changed, the antibiotic dosage is controlled from the source, the flavoring agent, sodium alginate, calcium chloride and antibiotics are compounded, the compound microsphere is obtainedby using a liquid drop method and a freeze drying method, has the effects of improving the addition density of antibiotics and the intake rate of diseased fishes, reducing the residual quantity of water bodies which are not utilized with the antibiotics, and achieving the effect of controlling antibiotic pollution in the water while ensuring the curative effect of fish diseases, and the product is wide in raw material source and low in cost, and the prepared microsphere is environmentally friendly.

Description

[0001] (1) Technical field [0002] The invention relates to a method for controlling antibiotic residues in fresh water, in particular to a drug-loaded composite microsphere and its application for controlling antibiotic pollution in fresh water aquaculture. [0003] (2) Background technology [0004] Antibiotics, as important drugs against bacterial diseases in aquaculture, play an irreplaceable role at this stage. The use of antibiotics in aquaculture to treat and prevent bacterial diseases began in the 1950s. With the rapid development of the aquaculture industry, the frequency of diseases in the breeding process is increasing, and the scope and amount of antibiotics used as veterinary drugs are increasing day by day. And there is the problem of antibiotic drug abuse. Its feeding methods mainly include oral method, soaking method, whole pond sprinkle method, injection method, hanging bag method, dipping method and rubbing method. These extensive feeding methods make only a...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A23K50/80A23K20/163A23K20/195A23K20/24A23K20/111A23K20/142A23K20/105A01K61/13A61K9/50A61K47/36A61K47/02A61K31/63A61K31/65A61P1/00A61P33/02A61P31/04A61P17/00
CPCA23K50/80A23K20/163A23K20/195A23K20/24A23K20/111A23K20/142A23K20/105A01K61/13A61K9/5036A61K9/501A61K31/63A61K31/65A61P1/00A61P33/02A61P31/04A61P17/00Y02A40/81
Inventor 张明蔡忠侠潘响亮张银
Owner ZHEJIANG UNIV OF TECH
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