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Hydrogel vascular embolism material and shape memory embolism treatment method

A technology of vascular embolization and treatment method, which is applied in the field of hydrogel vascular embolization materials and its preparation, which can solve the problems of incompact embolization, high cost, and high recanalization rate of blood vessels, and achieve excellent temperature-responsive shape memory characteristics and low preparation costs , The effect of simple preparation process

Active Publication Date: 2019-12-13
ZHEJIANG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, precious metal microcoils have disadvantages such as inability to compact embolization, high rate of vascular recanalization, and high cost.

Method used

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  • Hydrogel vascular embolism material and shape memory embolism treatment method
  • Hydrogel vascular embolism material and shape memory embolism treatment method
  • Hydrogel vascular embolism material and shape memory embolism treatment method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] 7.3910 g of 2-phenoxyethyl acrylate, 1.8147 g of acrylamide, and 0.0230 g of polyethylene glycol diacrylate (molecular weight=700) were dissolved in 8.47 g of dimethylsulfoxide. After being fully dissolved, argon gas was continuously passed into the solution for 30 minutes to remove oxygen in the solution, and then 0.0316 g of azobisisoheptanonitrile was added to the solution and fully dissolved to obtain a gel precursor solution.

[0036] Inject the gel precursor solution into a cylindrical mold (inner diameter = 3.0mm), seal the mold and place it in an incubator, adjust the temperature of the incubator to 50°C to thermally initiate monomer polymerization, and continue the reaction for 10 hours. Columnar organogels based on sulfoxide as solvent.

[0037] Take the columnar organogel out of the mold and replace it with water 50 times the mass of the organogel, and replace the water every 12 hours for 10 consecutive days to fully replace dimethyl sulfoxide with water, and...

Embodiment 2

[0042]4.9219 g of 2-phenoxyethyl acrylate, 2.7294 g of acrylamide, and 0.0229 g of polyethylene glycol diacrylate (molecular weight=700) were dissolved in 9.90 g of dimethylsulfoxide. After fully dissolving, argon gas was continuously passed into the solution for 30 minutes to remove oxygen in the solution, and then 0.0321 g of azobisisoheptanonitrile was added to the solution and fully dissolved to obtain a gel precursor solution.

[0043] Inject the gel precursor solution into a cylindrical mold (inner diameter = 3.0mm), seal the mold and place it in an incubator, adjust the temperature of the incubator to 50°C to thermally initiate monomer polymerization, and continue the reaction for 10 hours. Columnar organogels based on sulfoxide as solvent.

[0044] Take the columnar organogel out of the mold and replace it with water 50 times the mass of the organogel, and replace the water every 12 hours for 10 consecutive days to fully replace dimethyl sulfoxide with water, and then ...

Embodiment 3

[0047] 1.2301 g of 2-phenoxyethyl acrylate, 4.0961 g of acrylamide, and 0.0228 g of polyethylene glycol diacrylate (molecular weight=700) were dissolved in 12.21 g of dimethylsulfoxide. After being fully dissolved, argon gas was continuously passed into the solution for 30 minutes to remove oxygen in the solution, and then 0.0322 g of azobisisoheptanonitrile was added to the solution and fully dissolved to obtain a gel precursor solution.

[0048] Inject the gel precursor solution into a cylindrical mold (inner diameter = 3.0mm), seal the mold and place it in an incubator, adjust the temperature of the incubator to 50°C to thermally initiate monomer polymerization, and continue the reaction for 10 hours. Columnar organogels based on sulfoxide as solvent.

[0049] Take the columnar organogel out of the mold and replace it with water 50 times the mass of the organogel, and replace the water every 12 hours for 10 consecutive days to fully replace dimethyl sulfoxide with water, an...

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Abstract

The invention discloses a hydrogel vascular embolism material and a shape memory embolism treatment method. The hydrogel vascular embolization material is obtained by free radical copolymerization ofa hydrophobic monomer containing a benzene ring, a hydrophilic monomer capable of forming an intermolecular hydrogen bond and a cross-linking agent, the hydrogel vascular embolization material is formed by crosslinking physical crosslinking points formed by hydrophobic association and hydrogen bond interaction and covalent crosslinking points generated by chemical crosslinking. The vascular embolism material can achieve the purpose of vascular embolism, has excellent mechanical properties, and has the characteristics of relatively high breaking strain and breaking stress, excellent fatigue resistance, excellent resilience and the like.

Description

technical field [0001] The invention belongs to the technical field of polymer materials, and in particular relates to a hydrogel vascular embolization material and a preparation method thereof. Background technique [0002] Transcatheter arterial embolization is a clinically effective method for a wide range of tumor and vascular diseases. In principle, it has a significant therapeutic effect on some unresectable hypervascular solid tumors, intracranial aneurysms, arteriovenous malformations, and various difficult-to-control non-blood disease hemorrhages. Precious metal microcoils are commonly used clinical vascular embolism materials, and are an important means of treating aneurysms. The precious metal microcoils are implanted into the aneurysm through interventional surgery and twisted into groups to form larger emboli. The purpose of embolism. This method has gradually replaced traditional surgery, and has the advantages of less trauma, relatively simple surgery, and q...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L24/00A61L24/06C08F220/30C08F220/56C08F222/20C08J3/075
CPCA61L24/001A61L24/0031A61L24/06C08F220/30C08F220/56C08J3/075C08L33/26
Inventor 俞豪杰梁瑞雪王立
Owner ZHEJIANG UNIV
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