Green and efficient preparation method for aqueous phase iron oxide nanoparticles

Abstract

The invention discloses a green and efficient preparation method for aqueous phase iron oxide nanoparticles. The method comprises the following steps: respectively introducing a mixed solution of an Fe<3+> salt and an Fe<2+> salt or an Fe<2+> salt solution, an alkali solution and a surfactant solution into channels of an FNC (ionic flash nanoprecipitation) device, and enabling the solutions in different channels to reach an eddy-mixing zone simultaneously to be rapidly mixed; performing a reaction on the mixed liquid under an ice bath condition, and further performing heating aging so as to obtain a muddy solution; centrifuging the muddy solution, collecting supernate, adding acetone for precipitation, performing centrifugation so as to obtain precipitate, and dissolving the precipitate with distilled water, so as to obtain the aqueous phase iron oxide nanoparticles. By adopting a rapid ion mixing and precipitation technique, the obtained product has good particle size distribution andstability, inorganic phase-aqueous phase conversion operation is avoided, and green and nontoxic aqueous phase iron oxide nanoparticles can be directly prepared, can be directly used in biochemical application of aqueous phases, and have large application prospects.

Description

technical field [0001] The invention relates to the technical field of nano-iron oxide synthesis, and more specifically, to a green and efficient preparation method of aqueous-phase nano-iron oxide particles. Background technique [0002] Nano-iron oxide (Iron oxide Nanoparticle, ION) has attracted much attention in the field of biomedicine. It has been widely used as a contrast-enhancing reagent for magnetic resonance imaging, magnetic hyperthermia, and biosensing. A series of synthesis methods of nano-iron oxide have been developed in previous studies, mainly including microemulsion method, sol-gel method, hydrothermal synthesis method, high temperature thermal decomposition method and co-precipitation method. Among them, the microemulsion method refers to the preparation of nano-iron oxide in the oil-water dispersion system. This method forms a nano-reactor with the water-in-oil system. With the help of Fe 2+ , Fe 3+ Mineralization under ionic alkaline conditions can sy...

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Problems solved by technology

[0003] Most of the above-mentioned existing nano-iron oxide preparation methods use a large amount of environmentally harmful organic solvents, and most of the ION prepared by the microemulsion method, sol method, and high-temperature thermal decomposition method are nano-iron oxide dispersed in an organic phase, which cannot be directly For biomedical applications in aqueous phase

Although it has been reported to modify the surface of the ION system dispersed in the organic phase and transfer it to the aqueous phase, due to the large specific surface energy of the particles, particle agglomeration and sedimentation are prone to occur during the modification process; and the complicated preparation process increases the product cost.

In the conventional co-precipitation method, due to the fast mineralization reaction rate of salt ions, it is difficult to achieve effective control, which often results in excessive particle size distribution of nanoparticles, poor system stability, and poor repeatability between batches of prepared particles. Microemulsion The method is limited by the ratio of oil to water in the system, only a small amount of preparation can be carried out, and impurities are prone to exist on the surface

In the sol-gel method, it is easy to introduce sol-gel matrix components, which may have a certain impact on its application, and the above methods cannot achieve large-scale batch preparation of nano-iron oxide

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