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Composite process method for preparing intravascular stent

A vascular stent and composite technology technology, which is applied in medical science, filament/thread forming, electrospinning, etc., can solve the problems of limited source of autologous blood vessels, difficult to meet the performance requirements of vascular stents, and expensive allogeneic decellularization technology. , to achieve the effect of accelerating endothelialization, favorable adsorption and good biocompatibility

Active Publication Date: 2019-12-24
SHANGHAI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, large-diameter artificial blood vessels (>6mm) made of materials such as metal, nylon, and polytetrafluoroethylene have achieved extensive success in the field of repairing large and medium-sized artery defects. However, there is no suitable artificial blood vessel for small-diameter blood vessels (<6mm). Solution, now the main treatment method is blood vessel transplantation, but due to the limited source of autologous blood vessels and the high price of allogeneic decellularization technology, a large number of artificial blood vessels are clinically needed as transplant substitutes
[0003] With the extensive research on vascular stents in recent years, it is found that the best way to prepare vascular stents is to imitate the three-layer structure of natural blood vessels to achieve the purpose of vascular transplantation. The performance requirements of the bracket

Method used

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  • Composite process method for preparing intravascular stent
  • Composite process method for preparing intravascular stent
  • Composite process method for preparing intravascular stent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] A composite process method for preparing vascular stents, comprising the following steps:

[0039] a. Dissolve PLCL and PEG in a mixed solution of calcium chloride and N,N-dimethylformamide with a volume ratio of 1:1 according to the mass ratio of 5:1, and prepare a 150 mg / mL solution as the oil phase, and add The endothelial growth factor trimethylated chitosan is used as the water phase, the oil phase and the water phase are fully mixed at a ratio of 10:1, and stirred until a stable water-emulsion solution is prepared.

[0040] b. Load the water-emulsion solution in a into the cylinder for electrospinning, such as figure 1 As shown, a 316L stainless steel solid electrode rod with a diameter of 2.5 cm is used as a receiving rod to collect electrospinning, and the receiving range length of the receiving rod to receive electrospinning on the shaft is 7 mm, wherein the distance between the receiving rod and the needle The voltage was 10kv, the injection speed was 0.8mL / h...

Embodiment 2

[0046] This embodiment is basically the same as Embodiment 1, a composite process method for preparing a vascular stent, comprising the following steps:

[0047] a. Dissolve PLCL and PEG in a mixed solution of calcium chloride and N,N-dimethylformamide with a volume ratio of 1:1 according to the mass ratio of 7:1, and prepare a 250mg / mL solution as the oil phase, and add Endothelial growth factor trimethylated chitosan is used as the water phase, the oil phase and the water phase are fully mixed at a ratio of 15:1, and stirred until a stable water-emulsion solution is prepared.

[0048] b. Load the water-emulsion solution in a into the barrel for electrospinning, use a 316L stainless steel solid electrode rod with a diameter of 2.5cm as the receiving rod to collect the electrospinning, and control the receiving rod to receive the electrospinning on the shaft The length of the receiving range is 8mm, the voltage between the receiving rod and the needle is 10kv, the injection sp...

Embodiment 3

[0054] This embodiment is basically the same as Embodiment 1, a composite process method for preparing a vascular stent, comprising the following steps:

[0055] a. Dissolve PLCL and PEG in a mixed solution of calcium chloride and N,N-dimethylformamide with a volume ratio of 1:1 according to the mass ratio of 10:1, and prepare a 350 mg / mL solution as the oil phase. The endothelial growth factor trimethylated chitosan is used as the water phase, the oil phase and the water phase are fully mixed at a ratio of 20:1, and stirred until a stable water-emulsion solution is prepared.

[0056] b. Load the water-emulsion solution in a into the barrel for electrospinning, use a 3cm diameter 316L stainless steel solid electrode rod as a receiving rod to collect the electrospinning, and control the receiving rod to receive the electrospinning on the shaft The length of the receiving range is 9mm, the voltage between the receiving rod and the needle is 15kv, the injection speed is 1.2mL / h, ...

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Abstract

The invention relates to a composite process method for preparing an intravascular stent, which adopts two different processes to prepare a three-layer intravascular stent structure, adopts PLCL, PEGand endothelial growth factors as inner-layer materials, adopts electrospinning, and forms axially ordered spun material; a middle layer is collagen, an electrochemical method is adopted, and the prepared collagen layer is firmer than collagen hydrogel; an outermost layer adopts electrospinning, the material is PLCL, and the spun material is collected to be circumferentially ordered. The intravascular stent prepared by the invention well simulates the three-layer structure of a natural blood vessel, and has a wide prospect in clinical application.

Description

technical field [0001] The invention relates to a composite process method for preparing a vascular stent, which is applied in the fields of biomanufacturing technology and tissue repair. Background technique [0002] Cardiovascular disease has become one of the main causes of death in the world. The main causes of cardiovascular disease are intimal hyperplasia and thrombosis, which lead to vascular occlusion. Once vascular occlusion occurs, it will lead to tissue ischemia far from the heart. make it lose its original organizational function. At present, large-diameter artificial blood vessels (>6mm) made of metal, nylon, polytetrafluoroethylene and other materials have achieved extensive success in the field of human large and medium-sized artery defect repair, but there is no suitable artificial blood vessel for small-diameter blood vessels (<6mm). Solution, now the main treatment method is blood vessel transplantation, but due to the limited source of autologous bl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/40A61L27/50A61L27/24A61L27/18A61L27/54A61L27/22D01D5/00
CPCA61L27/18A61L27/227A61L27/24A61L27/50A61L27/507A61L27/54A61L2300/414A61L2430/22D01D5/003D01D5/0076C08L67/04
Inventor 胡庆夕沈志鹏张海光刘随红
Owner SHANGHAI UNIV
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