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A tape-based electrochemical sweat sensor

A sensor and electrochemical technology, applied in the field of tape-based electrochemical sweat sensors, can solve the problems of insufficient sensitivity in sweat collection and detection, and achieve the effects of low cost and convenient use.

Active Publication Date: 2020-11-20
UNIV OF SCI & TECH BEIJING
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The present invention provides a tape-based electrochemical sweat sensor in order to overcome the shortcomings of the existing sweat sensor in the prior art that it is not easy to realize the collection and detection of sweat.

Method used

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  • A tape-based electrochemical sweat sensor
  • A tape-based electrochemical sweat sensor
  • A tape-based electrochemical sweat sensor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Example 1: Preparation of Tape-Based Electrode

[0026] Step 1: Electrode sputtering. like figure 1 As shown, a commercially available tape was carefully pasted on the back of the patterned mask with six circular micro-holes (including connecting circuits), and placed in a magnetron sputtering apparatus (gold sputtering), sputtering power 80w, For 10 min, a planar gold working electrode with a patterned array was obtained. Subsequently, the four micro-holes of the mask were sealed with adhesive tape, and then placed in the magnetron sputtering apparatus (silver sputtering) again, with a sputtering power of 80w and a sputtering time of 5min to obtain two silver reference electrodes.

[0027] Step 2: Insulation layer encapsulation. Take a piece of PET film, punch out the same patterned micro-holes as in step 1 with a hole punch, and carefully glue it to the adhesive layer, exposing only the six electrodes of the sputtering, covering the external transmission circuit. ...

Embodiment 2

[0030] Example 2: Preparation of Janus Wettable Film

[0031] Dissolve 5g of polyurethane (PU) particles in 45g of dimethylformamide (DMF) solution, stir magnetically for 2h until the PU particles are completely dissolved to obtain a 10wt% PU solution, which is then poured into the syringe of the electrospinning machine. Cut commercially available medical gauze into a 20×30cm strip and stick it on the receiving table about 15cm away from the syringe needle. Start the machine to start electrospinning, voltage 15kV, injection speed 2mL h- 1 , spinning time 5min. Put the gauze spun with PU in a fume hood for 24 hours until it is completely dry and set aside. The side spun with the PU film is the hydrophobic side, and the side not spun with the PU film is the hydrophilic side. When the hydrophobic side is attached to the skin, this Janus wettable membrane is able to adequately wick sweat away from the body surface, but not when the hydrophilic side is attached to the skin. The...

Embodiment 3

[0032] Embodiment 3: Glucose detection

[0033] Electrode modification: First make up to 1% chitosan solution, dissolve chitosan in 2% acetic acid, stir magnetically for 1 hour; then add graphene oxide (2 mg / mL) and ultrasonicate for 30 minutes to prepare chitosan / graphene oxide viscous solution; next, the chitosan / graphene oxide solution was mixed with glucose oxidase solution (10 mg / mL, PBS, pH=7.2) in a volume ratio of 2:1 to obtain glucose oxidase / chitosan Sugar / graphene oxide solution. 3 μL of glucose oxidase / chitosan / graphene oxide solution was added dropwise to the dendritic gold electrode, protected from light, and dried at 4° C. overnight to obtain a glucose sensor.

[0034] Detection: Take a clean test tube, add weighed anhydrous glucose and deionized water, and prepare glucose standard solutions with concentrations of 0 mM, 0.25 mM, 0.5 mM, 0.75 mM, 1 mM and 1.25 mM, respectively, for use. Then take another dry test tube to prepare a glucose test solution with a ...

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Abstract

The invention provides an adhesive tape-based electrochemical sweat sensor, and belongs to the technical field of chemical detection sensors. The sensor takes a commercially available adhesive tape asa substrate and comprises a sweat absorbing layer and an electrochemical detection layer from bottom to top. The sweat absorbing layer is composed of a PET film with micropores, and the micropores are filled with a Janus wettability film; the electrochemical detection layer is composed of an electrode printed on an adhesive tape; and the Janus wettability film in the micropore area is in direct contact with the surface of the electrode, so that sweat can be quickly transferred from the skin side to the electrode side. A double-electrode electrochemical sensing system composed of nano dendritic gold and Ag / AgCl can detect multiple components of sweat simultaneously, sensitively and in real time, and includes but not limited to glucose, lactic acid, sodium ions and potassium ions. The wearable adhesive tape-based electrochemical sweat sensor is low in cost, convenient to use and particularly suitable for real-time detection of sweat.

Description

technical field [0001] The invention relates to the technical field of chemical detection sensors, in particular to a tape-based electrochemical sweat sensor. Background technique [0002] Blood testing has always been the preferred standard for current medical diagnosis and analysis. Blood analysis is invasive to the human body, needs to be performed in a standardized laboratory, and cannot achieve continuous monitoring. Sweat is a fluid secreted by sweat glands, mainly composed of water, and contains various electrolyte ions (sodium, potassium, calcium, and chloride) and human metabolites (glucose, lactate, uric acid, urea, etc.). Therefore, sweat is an important non-invasive detection object that can be used to monitor the degree of electrolyte imbalance, metabolism and dehydration in real time. Sweat glucose levels correlate with blood glucose levels, salt concentrations in sweat may be associated with cystic fibrosis; pH in sweat may be associated with skin disease or ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N27/30G01N27/327A61B10/00
CPCA61B10/0064G01N27/30G01N27/3277G01N27/3278
Inventor 许太林何学成张学记
Owner UNIV OF SCI & TECH BEIJING
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