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A method for preparing porous bone repair scaffolds with different magnesium phosphate phases based on 3D printing technology

A magnesium phosphate, 3D printing technology, applied in the fields of biomedical engineering and biomedical materials, to achieve the effects of simple raw materials, rapid preparation and low cost

Active Publication Date: 2021-07-27
TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there is no general method based on material extrusion molding technology that can be used to prepare a variety of magnesium phosphate phase porous bone repair scaffold materials

Method used

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  • A method for preparing porous bone repair scaffolds with different magnesium phosphate phases based on 3D printing technology
  • A method for preparing porous bone repair scaffolds with different magnesium phosphate phases based on 3D printing technology
  • A method for preparing porous bone repair scaffolds with different magnesium phosphate phases based on 3D printing technology

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Weigh 4g of magnesium oxide (particle size less than 100nm), add 4mL of an aqueous solution containing 1% hydroxypropyl methylcellulose into the solid powder, and stir with a metal spoon for 10 minutes to form a thick paste. Transfer the paste to the feed box of the 3D printer, input the pre-designed data file, and load the feed box with an air pressure of 0.3MPa, run the 3D printer, and prepare a square-shaped three-dimensional porous raw material. The raw material was immersed in 10 mL of calcium dihydrogen phosphate (0.5M) aqueous solution at 60°C for 3 days, the scaffold material was cleaned and dried at 60°C to obtain a bone repair scaffold material with a porous three-dimensional structure. The obtained stent material is ground into powder, and X-ray diffraction is carried out, see figure 1 , the composition of the scaffold material is CaHPO 4 with MgHPO 4 , and a small amount of Mg(OH) 2 , Incompletely reacted MgO. figure 2 is the SEM picture of the scaffold...

Embodiment 2

[0058] Same as Example 1, the difference is that after obtaining the cube-shaped three-dimensional porous raw material, it is soaked in 10 mL potassium dihydrogen phosphate (1M) aqueous solution at 60° C. for 3 days. X-ray diffraction characterization, see Figure 6 , the composition of the scaffold material is struvite-(K)(MgKPO 4 ·6H 2 O), and a small amount of Mg(OH) 2 , Incompletely reacted MgO.

[0059] In this example, repeat the above experimental content and replace "hydroxypropyl methylcellulose" with gelatin, xanthan gum, tragacanth gum, locust bean gum, tamarind polysaccharide gum, Tianqing gum, guar gum, gelatin One or more of cold gum, carbomer, gum arabic, carrageenan, and pectin will not affect the performance of the product obtained.

Embodiment 3

[0061] Same as Example 1, the difference is that after obtaining the cube-shaped three-dimensional porous raw material, it is immersed in 10 mL of ammonium dihydrogen phosphate (2M) aqueous solution at 60° C. for 3 days. X-ray diffraction characterization, see Figure 7 , the component of the scaffold material is struvite (MgNH 4 PO 4·6H 2 O), and a small amount of Mg(OH) 2 , Incompletely reacted MgO.

[0062] In this example, repeating the above experiment content and replacing "hydroxypropyl methylcellulose" with one or more of polyvinylpyrrolidone, polyether F127, and polyether P123 does not affect the performance of the obtained product.

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Abstract

The invention discloses a method for preparing porous bone repair scaffolds with different magnesium phosphate phases based on 3D printing technology. The method uses one or more of magnesium oxide, magnesium hydroxide and basic magnesium carbonate as a base material to prepare a slurry, and then uses 3D printing technology to produce a raw material with a three-dimensional porous structure of a preset shape; and then The raw material is soaked in phosphate solution, washed and dried to prepare porous bone repair scaffold materials with different magnesium phosphate phases. The method has simple raw materials, rapid preparation and low cost, can control the phase of the product magnesium phosphate, and is convenient to combine with other substances beneficial to bone defect repair.

Description

technical field [0001] The invention relates to the technical fields of biomedical engineering and biomedical materials. More specifically, it relates to a method for preparing porous bone repair scaffolds in different phases of magnesium phosphate based on 3D printing technology. Background technique [0002] Human skeleton is the largest tissue in the human body and has a special hierarchical structure. Human bones have a certain ability to regenerate and self-repair small-sized defects, but they cannot repair themselves when the bone defect exceeds a critical size. Synthetic bone repair materials overcome the defects of autologous bone grafts and allogeneic bone grafts, and have attracted extensive attention from materials scientists and medical workers. Tissue engineering is a new interdisciplinary subject developed in the 1980s. Usually, the tissue cells cultured in vitro are planted on a scaffold material that has good biocompatibility and can be gradually degraded ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/12A61L27/56B33Y80/00
CPCA61L27/12A61L27/56A61L2430/02B33Y80/00
Inventor 郭燕川曹霄峰
Owner TECHNICAL INST OF PHYSICS & CHEMISTRY - CHINESE ACAD OF SCI