Method for depositing hydroxyapatite on metal surface and metal implant

A hydroxyapatite and metal surface technology, applied in the field of medical devices, can solve the problems of low crystallinity of HA particles, high content of soluble calcium phosphate, poor surface binding force, etc., to suppress the generation of hydrogen, improve the purity and crystallization of HA Degree, improve the effect of electrical conductivity

Inactive Publication Date: 2020-01-24
SUZHOU MICROPORT ORTHORECON CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At the same time, for metal plants with three-dimensional structures such as voids formed on the surface, plasma spraying is a linear spraying, which cannot allow HA to enter the interior of the three-dimensional structure, and excessively thick coatings may even block the v

Method used

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  • Method for depositing hydroxyapatite on metal surface and metal implant
  • Method for depositing hydroxyapatite on metal surface and metal implant
  • Method for depositing hydroxyapatite on metal surface and metal implant

Examples

Experimental program
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Effect test

Embodiment 1

[0071] The method for depositing hydroxyapatite on the metal surface described in this embodiment is as follows:

[0072] First, a smooth titanium sheet with a side length of 25 mm and a thickness of 2 mm is provided as a metal substrate.

[0073]Next clean the titanium sheet. Pure water, isopropanol, and pure water were used as cleaning agents in sequence, and ultrasonic vibration was used to clean the titanium sheet, and the cleaning time was 15 minutes each time. Then, the titanium sheet was pickled in a mixed solution containing 20% ​​nitric acid and 5% hydrofluoric acid, and the pickling time was 20s. Finally, rinse the titanium piece in pure water for 3-4 times. Unless otherwise specified herein, "%" refers to mass percentage.

[0074] Next, a rough structure is formed on the surface of the titanium sheet. The cleaned titanium sheet was placed in a mixed acid solution containing 24% sulfuric acid and 9% hydrochloric acid, reacted in a water bath for 1 hour at 70° C.,...

Embodiment 2

[0082] The method for depositing hydroxyapatite on the metal surface described in this embodiment is as follows.

[0083] First, a smooth titanium sheet with a side length of 25 mm and a thickness of 2 mm is provided as a metal substrate.

[0084] Next clean the titanium sheet. Pure water, isopropanol, and pure water were used as cleaning agents in sequence, and ultrasonic vibration was used to clean the titanium sheet, and the cleaning time was 15 minutes each time. Then, the titanium sheet was pickled in a mixed solution containing 40% nitric acid and 3% hydrofluoric acid, and the pickling time was 20s. Finally, rinse the titanium piece in pure water for 3-4 times.

[0085] Next, a rough structure is formed on the surface of the titanium sheet.

[0086] In this embodiment, a micron-scale rough structure and a nano-scale rough structure are formed on the surface of the titanium sheet, and the specific operations are as follows:

[0087] Step 1): Place the cleaned titanium...

Embodiment 3

[0096] The method for depositing hydroxyapatite on the metal surface described in this embodiment is as follows.

[0097] First, a smooth titanium sheet with a side length of 25 mm and a thickness of 2 mm is provided as a metal substrate.

[0098] Next clean the titanium sheet. Pure water, isopropanol, and pure water were used as cleaning agents in sequence, and ultrasonic vibration was used to clean the titanium sheet, and the cleaning time was 15 minutes each time. Then, the titanium sheet was pickled in a mixed solution containing 30% nitric acid and 5% hydrofluoric acid, and the pickling time was 20s. Finally, rinse the titanium piece in pure water for 3-4 times.

[0099] Next, a rough structure is formed on the surface of the titanium sheet. The specific operation is as follows: in the fluorine-containing acid solution, the cleaned titanium sheet is used as the anode, and the graphite electrode sheet is used as the cathode, and the reaction is performed at a DC voltage...

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Abstract

The invention relates to a method for depositing hydroxyapatite on a metal surface and a metal implant. The method for depositing hydroxyapatite on the metal surface comprises the steps that a material substrate is provided; a rough structure is formed on the surface of the metal substrate; an electrolyte is provided; the metal substrate with the surface provided with the rough structure is placedin the electrolyte, and a hydroxyapatite layer is formed on the rough structure through electrochemical deposition; and the electrolyte is prepared with the raw materials of calcium salt, phosphate and hydrogen peroxide. A high-purity and high-crystalline HA coating is formed on the surface of the metal implant which is obtained with the method; and the HA coating has high binding force to the surface of the metal implant, so that the using safety and reliability of the metal implant are improved.

Description

technical field [0001] The invention relates to the technical field of medical devices, in particular to a method for depositing hydroxyapatite on a metal surface and a metal implant. Background technique [0002] Metal materials are widely used in the field of medical implants due to their excellent properties. Common metal materials such as stainless steel, titanium and titanium alloys, zirconium and zirconium alloys, cobalt-chromium alloys, etc., have become orthopedic and dental materials due to their good biocompatibility, low toxicity, suitable mechanical strength and sufficient corrosion resistance. The material of choice for hard tissue implantation and replacement. However, most metal materials tend to be biologically inert in the human body without special surface treatment. This makes it difficult for the metal implant to form an effective osseointegration interface with the surrounding bone tissue in the human body, which in turn leads to loosening of the metal...

Claims

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Application Information

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IPC IPC(8): C25D9/06A61L27/04A61L27/32A61L27/50
CPCA61L27/047A61L27/32A61L27/50A61L2400/18A61L2420/02A61L2430/02C25D9/06
Inventor 姚夏睿俞天白
Owner SUZHOU MICROPORT ORTHORECON CO LTD
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