Preparation method of hemostatic menstruation-regulating granules

A granulation and menstruation regulating technology, which is applied in the direction of medical preparations with non-active ingredients, medical preparations containing active ingredients, and pharmaceutical formulas, etc., can solve the problems of difficult operation of granulation process, unfavorable storage, easy bed collapse, etc., to achieve The process is simple, the production cycle is shortened, and the integrity is good

Inactive Publication Date: 2020-02-18
湖南安邦制药股份有限公司
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  • Abstract
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Problems solved by technology

Although this process omits the step of spray-drying the concentrated extract, the material is highly viscous due to the presence of donkey-hide gelatin and sucrose in the prescription. When spraying and granulating, the material is easily softened and adhered to the inner wall of the equipment, and the hygroscopicity is strong and the bed collapses easily. , leading to difficulties in the one-step granulation process, and the prepared granules are loose and small particles with strong hygroscopicity, which is not conducive to storage

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  • Preparation method of hemostatic menstruation-regulating granules

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preparation example Construction

[0036] One embodiment of the present invention provides a preparation method of hemostasis regulating menstruation granule, comprising the following steps S1-S6.

[0037] S1. Take astragalus, donkey-hide gelatin, codonopsis pilosula, white peony root, angelica, Agrimony, madder, bergamot, Dipsacus and auxiliary materials according to the formula of Zhixue Tiaojing granule.

[0038] In one embodiment, the Hemostasis Tiaojing Granules include the following raw materials in parts by weight: 45-50 parts of astragalus, 45-50 parts of donkey-hide gelatin, 43-48 parts of Codonopsis pilosula, 12-16 parts of white peony root, 10-50 parts of angelica 15 parts, 45-50 parts of agrimony, 20-28 parts of madder, 12-16 parts of bergamot, 12-16 parts of Dipsacus, 10-20 parts of pregelatinized starch and 25-30 parts of sucrose powder.

[0039] Further, in terms of parts by weight, the raw materials of Zhixue Tiaojing Granules include 48 parts of astragalus, 48 ​​parts of donkey-hide gelatin, 45...

Embodiment 1

[0065] 1) Raw materials: Astragalus 48kg, Ejiao 48kg, Codonopsis 45kg, Paeoniae Alba 15kg, Angelica 12kg, Agrimony 48, Rubia 24kg, Bergamot 12kg, Dipsacus 12kg, Precrossed starch 18kg and sucrose powder 27kg.

[0066] 2) Extraction of volatile oil from angelica and bergamot medicinal materials: Add 6 times the amount of water to angelica and bergamot, steam distillation and extraction for 4 hours, collect volatile oil, keep the mixed water extract of angelica and bergamot for later use, and keep the dregs of angelica and bergamot for later use ; Take β-cyclodextrin of 8 times the amount of the volatile oil, add an appropriate amount of purified water to mix, and adjust it into a paste, dilute the volatile oil with 4 times the amount of 95% ethanol, use a colloid mill to clathrate for 20 minutes, filter, and store at 50°C Dry at ~60°C to obtain β-cyclodextrin inclusion compound.

[0067] 3) Take half the amount of Astragalus membranaceus and dry it on a belt dryer at 70°C to 80...

Embodiment 2

[0074] Step 1) to step 4) of Embodiment 2 are the same as Embodiment 1.

[0075] 5) Pump the extract into a concentrator to concentrate to an extract with a specific gravity of 1.35 (measured at 60°C).

[0076] 6) Put the extract into a baking tray for vacuum drying, spread it evenly, control the temperature at 60°C-80°C, vacuum degree at -0.06--0.08MPa, and dry for 15 hours to obtain dry extract, powder it, and obtain the particle size It is 150 μm~250 μm, and the dry extract powder of water content is 6.0wt%, about 58kg.

[0077] 7) Take the crushed dry extract powder, donkey-hide gelatin powder, and sucrose powder, add astragalus ultrafine powder, and pregelatinized starch, mix evenly, and then pump it to the hopper of LG200 dry granulator through a vacuum feeder, and pass through the horizontal Feeding, the speed of horizontal feeding is 75r / min; to the pressing roller, the pressure is 13MPa, the operating speed of the pressing roller is 15r / min, and the displacement of the...

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Abstract

The invention relates to a preparation method of hemostatic menstruation-regulating granules. The preparation method comprises the following steps of: preparing materials according to a prescription of the hemostatic menstruation-regulating granules; mixing radix angelicae sinensis and fructus citri sarcodactylis; then, performing extraction by a distillation method; collecting volatile oil to obtain a mixed extraction solution and mixed medicine residues of the radix angelicae sinensis and the fructus citri sarcodactylis; performing inclusion on the volatile oil by beta-cyclodextrin to obtaina beta-cyclodextrin inclusion compound; crushing colla corii asini into colla corii asini powder; taking and crushing a half amount of radix astragali to respectively obtain ultrafine radix astragalipowder and coarse radix astragali powder; mixing the coarse radix astragali powder, the other half amount of radix astragali, the mixed medicine residues of the radix angelicae sinensis and the fructus citri sarcodactylis, radix codonopsis, radix paeoniae alba, herba agrimoniae, radix rubiae and radix dipsaci; performing water extraction, filtration and impurity removal to obtain a water extraction solution; then, merging the obtained water extraction solution with the mixed extraction solution of the radix angelicae sinensis and the fructus citri sarcodactylis; performing concentration to obtain an extract with the specific gravity being 1.25 to 1.35; performing vacuum drying treatment and crushing on the extract to obtain dry extract powder; uniformly mixing the dry extract powder, thecolla corii asini powder, the ultrafine radix astragali powder and auxiliary materials, and performing dry process granulation; and then, performing blending with the beta-cyclodextrin inclusion compound to obtain the hemostatic menstruation-regulating granules.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method of Zhixue Tiaojing Granules. Background technique [0002] Zhixue Tiaojing granules are mainly prepared from nine medicinal materials such as donkey-hide gelatin, angelica, bergamot, astragalus, codonopsis pilosula, and white peony. See expired menstrual blood, pale menstruation, mental fatigue, dizziness, lower abdominal distension, pale tongue, thin white fur, thready and weak pulse. [0003] At present, wet granulation and one-step granulation are mainly used in the preparation of Zhixue Tiaojing Granules. Among them, in the wet granulation process, the traditional Chinese medicine extract is concentrated into an extract with a relative density of about 1.1, and then spray-dried to obtain a dry cream powder, and then add donkey-hide gelatin powder, astragalus ultrafine powder and appropriate amount of auxiliary materials ...

Claims

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Application Information

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IPC IPC(8): A61K36/752A61K47/69A61P15/00A61K35/36
CPCA61K35/36A61K36/185A61K36/232A61K36/344A61K36/481A61K36/65A61K36/71A61K36/73A61K36/74A61K36/752A61K2236/331A61K2236/37A61K47/6951A61P15/00A61K2300/00
Inventor 文复权李艳波易小兰龚上羽覃华龙培
Owner 湖南安邦制药股份有限公司
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