Unlock instant, AI-driven research and patent intelligence for your innovation.

Conjugated zinc linoleate preparation and preparation method thereof

A technology of conjugated linoleic acid and zinc oleate, which is applied in pharmaceutical formulas, medical preparations containing active ingredients, metabolic diseases, etc., can solve problems such as adverse reactions, low absorption and utilization, and irritating the stomach, and achieve product purity High, stable product quality, uniform response effect

Inactive Publication Date: 2020-03-24
常州凯康生物科技有限公司
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] Inorganic zinc and small molecule organic zinc preparations currently on the market are poorly effective as food and drug supplements, irritate the stomach and cause related side effects, and thus need to be upgraded for quality improvement
Inorganic zinc (zinc sulfate, zinc chloride, zinc nitrate, etc.) has low absorption and utilization rate (only 7%), which is easy to stimulate the stomach and cause adverse reactions; organic acid zinc (zinc gluconate, zinc licorice, zinc acetate, zinc citrate) , amino acid zinc, zinc lactate, etc.) have a high zinc content, which inhibits the absorption of calcium, iron and other trace elements, leading to calcium deficiency, anemia and other symptoms

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Conjugated zinc linoleate preparation and preparation method thereof
  • Conjugated zinc linoleate preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Weigh 30g of conjugated linoleic acid in 450ml of distilled water at room temperature 25°C under nitrogen protection, add 45ml of 10%wt sodium hydroxide solution under stirring, and stir for 2 hours to obtain sodium conjugated linoleate solution;

[0026] (2), add 106ml of zinc chloride solution of 10%wt, stir while adding, form pale yellow granular substance, through centrifugation, obtain thick conjugated linoleic acid zinc preparation;

[0027] (3) The crude preparation was successively washed with distilled water, deionized water and methanol, dried in vacuum at 60° C., and pulverized to obtain 30.6 g of the product.

Embodiment 2

[0029] (1) Weigh 30g of conjugated linoleic acid in 300ml of distilled water at near room temperature 30°C under nitrogen protection, add 42ml of 10%wt sodium hydroxide solution under stirring, and stir for 4 hours to obtain conjugated linoleic acid sodium solution;

[0030] (2), add 160ml of zinc bromide solution of 10%wt, stir while adding, form pale yellow granular substance, through centrifugation, obtain thick conjugated linoleic acid zinc preparation;

[0031] (3) Wash the crude preparation successively with distilled water, deionized water and diethyl ether, vacuum-dry and pulverize at 50° C. to obtain 30.18 g of the product.

Embodiment 3

[0033] (1) Weigh 30g of conjugated linoleic acid in 300ml of methanol at near room temperature 35°C under nitrogen protection, add 48ml of 10%wt potassium hydroxide solution under stirring, and stir for 4 hours to obtain conjugated linoleic acid Potassium solution;

[0034] (2), add 180ml of zinc sulfate solution of 10%wt, stir while adding, form pale yellow granular matter, through centrifugation, obtain thick conjugated linoleic acid zinc preparation;

[0035] (3) The crude preparation was successively washed with distilled water, deionized water and methanol, dried in vacuum at 80° C., and pulverized to obtain 30.68 g of the product.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a conjugated zinc linoleate preparation and a preparation method thereof. The preparation is prepared from the following raw materials: conjugated linoleic acid and soluble zinc salt in a molar ratio of 2: (1.00-1.50), the preparation method comprises the following steps: carrying out saponification reaction on conjugated linoleic acid with biological functional activity and alkali metal alcoholate or alkali metal hydroxide at room temperature or near room temperature, and reacting with a soluble zinc salt solution to obtain conjugated zinc linoleate; the method disclosed by the invention is homogeneous reaction, simple in process, simple and convenient to operate, high in product purity and stable in property, and is particularly suitable for the application fieldwith higher requirements on product quality.

Description

technical field [0001] The invention relates to the technical field of nutritional supplement preparations, in particular to a zinc conjugated linoleate preparation and a preparation method thereof. Background technique [0002] Conjugated linoleic acid, discovered in the late 1980s, is a natural fatty acid with many important biological activities. Animal experiments have shown that conjugated linoleic acid has the functions of reducing fat, increasing muscle, anti-cancer, anti-atherosclerosis, enhancing body immunity, and improving bone tissue metabolism. As a newly discovered nutrient, conjugated linoleic acid does not have the so-called homology problem because it is a secondary metabolite of animals. In principle, there is no upper limit for use, and regular consumption is beneficial and harmless to the body. Adding a certain dose of conjugated linoleic acid in food can make up for the lack of human intake, enhance the body's ability to resist many diseases, and improv...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A23L33/12A23L33/16A61K33/30A61K31/201A61P3/02
CPCA23L33/12A23L33/16A61K33/30A61K31/201A61P3/02A23V2002/00A23V2200/30A23V2250/1642A61K2300/00
Inventor 刘康慨
Owner 常州凯康生物科技有限公司