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Preparation method of nerve repair drug-carrying system with electrical stimulation and angiogenesis promotion effects

A technology for promoting angiogenesis and nerve repair, applied in medical science, electrospinning, tissue regeneration, etc., can solve the problems of low regeneration ability of nerve tissue and unsatisfactory repair effect of peripheral nerve injury, etc., and achieve excellent biocompatibility, The effect of accelerating nerve repair without hindering nerve regeneration

Active Publication Date: 2020-04-10
深圳南泥湾科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the characteristics of highly differentiated nerve tissue and low regeneration ability, the repair effect of peripheral nerve injury is still unsatisfactory.

Method used

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  • Preparation method of nerve repair drug-carrying system with electrical stimulation and angiogenesis promotion effects

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Add 1.0g of natural graphite powder and 0.5g of sodium nitrate to a three-necked flask, place the three-necked flask in an ice bath and slowly add 23mL of concentrated sulfuric acid, continue stirring for 15 minutes, and then slowly add 4g of potassium permanganate to keep the system temperature at a constant temperature. Stirring was continued for 2 hours above 20°C. After removing the ice bath, the mixture in the three-necked flask was heated to 35°C and continuously stirred for 1.5h, then 46mL of deionized water was slowly added, and the system temperature was maintained at 98°C and stirred vigorously for 30min. The three-necked flask was placed in the air to cool naturally, and 140 mL of deionized water and 10 mL of hydrogen peroxide were added to terminate the reaction. At this time, the suspension in the flask turned bright yellow. After centrifugal separation, the filter cake is washed with 5% HCl aqueous solution and deionized water in sequence until it is neutra...

Embodiment 2

[0028] This example is basically the same as Example 1, except that the concentration of the GO suspension is changed from 1% to 2%, the concentration of the gelatin aqueous solution is changed from 20% to 15%, and the concentration of the chitosan solution is changed from 3%. 4%, the mixing ratio of the three remains unchanged.

Embodiment 3

[0030] This example is basically the same as Example 1, except that the concentration of the GO suspension is changed from 1% to 3%, the concentration of the gelatin aqueous solution is changed from 20% to 15%, and the concentration of the chitosan solution is changed from 3%. 4%, the mixing ratio of the three remains unchanged.

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PUM

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Abstract

The invention relates to a nerve repair drug-carrying system with bioelectrical stimulation and angiogenesis promoting effects and a preparation method thereof. Gelatin, chitosan, polylactic acid andother natural polymer components in the nerve repair drug-carrying system ensure good biocompatibility and no toxicity, polylactic acid can also meet the good mechanical property requirement of a catheter, catheter collapse in the nerve growth process is avoided, and excellent flexibility enables the nerve repair drug-carrying system not to hinder nerve regeneration. Due to the introduction of a conductive copolymer GO, the catheter has weak conductivity, meets the requirement of physiological current of a human body, and is beneficial to accelerating nerve repair; and by introducing a VEGF growth factor, an extracellular matrix microenvironment in a human body can be simulated to the maximum extent, nerve repair is promoted from the microvascular regeneration acceleration direction, and finally the nerve injury repair quality is improved.

Description

Technical field [0001] The invention relates to the technical field of biomedical materials, in particular to a nerve repair drug-carrying system with bioelectric stimulation and angiogenesis-promoting effects and a preparation method thereof. Background technique [0002] For a long time, peripheral nerve injury, especially long-segment nerve defect, has always been an important topic in neuroscience research, and it is also one of the urgent problems in the medical field. Studies have shown that although peripheral nerves have a certain regenerative ability, the efficiency of this regenerative ability is low and easily blocked by the surrounding scars, so that the regenerated axons are scattered and eventually form neuromas. At present, autologous nerve transplantation is regarded as the gold standard for the treatment of peripheral nerve injury. In recent years, with the tremendous development of tissue engineering, it has brought new hope for peripheral nerve regeneration. ...

Claims

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Application Information

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IPC IPC(8): A61L27/22A61L27/20A61L27/08A61L27/18A61L27/38A61L27/50A61L27/54A61L27/56A61F2/00D01D5/00
CPCA61F2/00A61F2002/0086A61L27/08A61L27/18A61L27/20A61L27/222A61L27/227A61L27/383A61L27/3878A61L27/50A61L27/54A61L27/56A61L2430/32D01D5/003D01D5/0069D01D5/0092
Inventor 徐海星李锐许沛虎黄志军宁偲偲张婉婷闫秀美马毓聪李意璇李信
Owner 深圳南泥湾科技有限公司
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