The invention discloses a GH4169 high-temperature alloy capable of determining the component coordinated change relation on the basis of a cluster type method and a preparation method. According to the method, GH4169 high-temperature alloying elements are divided into Ni-like elements which enter a cluster type and contain Ni, Fe, Co and Cu, Cr-like elements which contain Cr, Mo, Mn and Si, Nb-like elements which contain Nb, Al and Ti, and trace elements which do not enter the cluster type and contain C, P, S, B, Mg and Ca; the coordinated change relation of all the elements is that Ni+1.02Fe+Co+Cu is larger than or equal to 68.93 and smaller than or equal to 72.68, Cr+0.64Mo+Mn+1.67Si is larger than or equal to 19.84 and smaller than or equal to 22.78, and Nb+3.22Al+1.85Ti is larger than or equal to 8.67 and smaller than or equal to 9.81. The coordinated change relation of the new components is simple and effective, the component standardization mode of the high-temperature alloy is thoroughly reformed, and the development of the high-temperature alloy is promoted.