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High-strength multifunctional hydrogel and preparation method and application thereof

A hydrogel, multi-functional technology, applied in pharmaceutical formulations, medical science, prostheses, etc., can solve the problems of limited application of stretchable hydrogels, no self-healing function, poor biocompatibility, etc. Rich in biological functions, notch insensitivity, and low cost

Inactive Publication Date: 2020-05-08
SHANGHAI JIAO TONG UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Among double-network hydrogels, chemically cross-linked double-network hydrogels exhibit high mechanical properties, but due to the irreversibility of covalent bond breakage and the cytotoxicity of chemical cross-linking agents, traditional chemically cross-linked hydrogels usually exhibit resistance The problems of low fatigue and poor biocompatibility greatly limit the application of stretchable hydrogels in the fields of biological tissue engineering and so on.
[0005] Chinese patent CN107011609A discloses a high-strength chemical-physical double-network hydrogel with self-recovery ability. The first chemical network is obtained by polymerizing hydrophilic monomers or mixing and reacting hydrophilic macromolecules. Polysaccharides and their derivatives The second physical network is formed through physical cross-linking. Due to the physical network formed by non-covalent bond cross-linking, the hydrogel has certain notch insensitivity and self-recovery ability, but because the hydrogel still contains Chemical network, and a cytotoxic chemical cross-linking agent is introduced during the formation of the chemical network, so its biocompatibility is poor
The hydrogel has low strength and low modulus, which limits its application in areas with high mechanical strength requirements such as cartilage support materials, and because its first layer network is formed by covalent cross-linking, it does not have self-healing function

Method used

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  • High-strength multifunctional hydrogel and preparation method and application thereof
  • High-strength multifunctional hydrogel and preparation method and application thereof
  • High-strength multifunctional hydrogel and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Add 0.3g of gellan gum and 8.217g of acrylamide monomer into a reaction bottle containing 21g of deionized water, seal the reaction bottle and place it in an oil bath, gradually stir and heat to 90°C, and keep stirring at 90°C for 2 hours To fully dissolve the gellan gum.

[0044] Then gradually add NaCl solution prepared in advance, 2.1 g of sodium lauryl sulfate, 0.264 g of photoinitiator I2959, and 900 μL of octadecyl methacrylate.

[0045] After all the reactants are added, continue to stir at 90°C until a transparent, low-viscosity solution is obtained, and then inject it into the corresponding mold.

[0046] Put the mold into a curing apparatus for photopolymerization for 5 minutes to form a polyacrylamide network modified with hydrophobic side chains.

[0047] Leave it to cool at room temperature for 2 hours to obtain a gellan gum / hydrophobic polyacrylamide hydrogel.

Embodiment 2

[0049] Add 0.1g of carrageenan and 2.74g of acrylamide monomer into a reaction bottle containing 7g of deionized water, seal the reaction bottle and place it in an oil bath, gradually stir and heat to 70°C, and keep stirring at 70°C for 2 hours To fully dissolve the carrageenan.

[0050] Then gradually add NaCl solution prepared in advance, 0.7 g sodium lauryl sulfate, 0.0881 g photoinitiator I2959, and 300 μL octadecyl methacrylate.

[0051] After all the reactants are added, continue to stir at 70°C until a transparent, low-viscosity solution is obtained, and then inject it into the corresponding mold.

[0052] Put the mold into a curing apparatus for photopolymerization for 5 minutes to form a polyacrylamide network modified with hydrophobic side chains.

[0053] Standing and cooling at room temperature for 2 hours, a carrageenan / hydrophobic polyacrylamide hydrogel was obtained.

Embodiment 3

[0055] Add 0.05g of gellan gum and 2.74g of acrylamide monomer into a reaction bottle containing 7g of deionized water, seal the reaction bottle and place it in an oil bath, gradually stir and heat to 60°C, and keep stirring at 60°C for 2h To fully dissolve the gellan gum.

[0056] Then gradually add NaCl solution prepared in advance, 0.7 g sodium lauryl sulfate, and 300 μL octadecyl methacrylate.

[0057] After all the reactants have been added, continue to stir at 60°C until a transparent, low-viscosity solution is obtained, then add 0.1 g of ammonium persulfate, stir for 3 minutes, and quickly inject it into the mold.

[0058] React at 60°C for 20 minutes to obtain a hydrophobic poly-N,N-dimethylacrylamide network.

[0059] Put it in the refrigerator and let it stand for cooling for 0.5h, and finally obtain the carrageenan / hydrophobic polyacrylamide hydrogel.

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Abstract

The invention relates to a high-toughness multifunctional hydrogel and a preparation method and application thereof. The high-toughness self-healing biocompatible double-physical-network hydrogel is obtained by taking natural polymer polysaccharide and hydrophobic side chain modified hydrophilic polymer as matrixes and adopting the structural design of double physical networks. Compared with the prior art, the hydrogel provided by the invention has restorable and self-healing capabilities, good biocompatibility and excellent mechanical properties, and can be applied as a cartilage repair material to biological tissue engineering.

Description

technical field [0001] The invention relates to the technical field of hydrogel, in particular to a recoverable, self-healing, biocompatible high-strength hydrogel and its preparation method and application. Background technique [0002] Hydrogel is a polymer soft wet material with three-dimensional cross-linked network structure and containing a large amount of water (50-90%). According to the bonding mode of the crosslink points in the network structure, hydrogels are divided into chemical hydrogels and physical hydrogels. At present, hydrogel has been widely used in all aspects of people's daily life. For example, it can not only be used as a medium to protect cells and other substances, but also has high conductivity. In addition, hydrogels are also injectable and easy to 3D print, which makes them highly valuable in customizable medical treatment. For example, hydrogels have been widely used in drug controlled release, regenerative medicine, in vitro diagnosis, etc. H...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F251/00C08F251/02C08F220/56C08F220/18C08F220/54C08F220/06C08F220/58C08F2/50A61L27/20A61L27/16A61L27/52A61L27/56A61L27/50
CPCA61L27/16A61L27/20A61L27/50A61L27/52A61L27/56A61L2400/06A61L2430/06A61L2430/34C08F2/50C08F251/00C08F251/02C08F289/00C08F220/56C08F220/54C08F220/06C08L5/00C08L33/26
Inventor 王艳洁刘思俊俞炜
Owner SHANGHAI JIAO TONG UNIV