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Production system and method of acetaminophen

A paracetamol and production system technology, applied in the field of paracetamol production systems, can solve the problems of affecting the quality of acetaminophen, easy oxidation, discoloration and deterioration, and many aminophenol impurities, so as to save steam consumption and be difficult to oxidize. The effect of discoloration and less impurities

Pending Publication Date: 2020-05-19
JIHENG PHARMA HENGSHUI CITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Due to the use of dry, powdered p-aminophenol, it not only consumes steam, increases the cost, increases labor intensity, but also easily produces dust and pollutes the environment
If the p-aminophenol crude product after the hydrogenation reaction is directly used as raw material, it will be easily oxidized, discolored and deteriorated due to the large amount of aminophenol impurities, which will directly affect the quality of the product paracetamol

Method used

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  • Production system and method of acetaminophen
  • Production system and method of acetaminophen
  • Production system and method of acetaminophen

Examples

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Effect test

Embodiment 1

[0062] The reaction system that the production method of paracetamol of the present embodiment adopts is as figure 1 shown.

[0063] The production method of the present embodiment comprises the following steps:

[0064] (1) Preparation and dissolution: 1900kg of p-aminophenol with a content of 96% and a purity of 99.62%, 2500kg of dilute acid (glacial acetic acid aqueous solution with a mass concentration percentage of 58%), and 9.5kg of sodium metabisulfite (mass ratio: 1:1.32:0.005) Put it into the preparation material dissolving kettle, mix evenly, obtain the raw material mixed liquid, set aside.

[0065] (2) Acylation reaction: the raw material mixture is transported to the acylation kettle by a pump, (the air in the pipeline, the dissolution kettle, and the acylation kettle is replaced by nitrogen) and 1253kg of glacial acetic acid (the mole of undried p-aminophenol and glacial acetic acid) is added Ratio of 1:1.2) was slowly heated to about 100°C and refluxed for 3 ho...

Embodiment 2

[0073] The reaction system that the production method of paracetamol of the present embodiment adopts is as figure 1 shown.

[0074] The production method of the present embodiment comprises the following steps:

[0075] (1) Preparation and dissolution: 1900kg of p-aminophenol with a content of 97% and a purity of 99.78%, 2500kg of dilute acid (glacial acetic acid aqueous solution with a mass concentration percentage of 50%), and 9.5kg of sodium metabisulfite (mass ratio: 1:1.32:0.005) Put it into the preparation material dissolving kettle, mix evenly, obtain the raw material mixed liquid, set aside.

[0076](2) Acylation reaction: the raw material mixture is transported to the acylation kettle by a pump, (the air in the pipeline, the dissolution kettle, and the acylation kettle is replaced by nitrogen) and 1464kg of glacial acetic acid (the mole of undried p-aminophenol and glacial acetic acid) is added Ratio of 1:1.3) was slowly heated to about 110°C and refluxed for 3 hou...

Embodiment 3

[0082] The reaction system that the production method of paracetamol of the present embodiment adopts is as figure 1 shown.

[0083] The production method of the present embodiment comprises the following steps:

[0084] (1) Prepare materials and dissolve: 1900kg of p-aminophenol with a content of 96.5% and a purity of 99.68%, 2500kg of dilute acid (glacial acetic acid aqueous solution with a mass concentration percentage of 64%), and 9.5kg of sodium metabisulfite (mass ratio: 1:1.32:0.005) Put it into the preparation material dissolving kettle, mix evenly, obtain the raw material mixed liquid, set aside.

[0085] (2) Acylation reaction: the raw material mixture is transported to the acylation kettle by a pump, (the air in the pipeline, the dissolution kettle, and the acylation kettle is replaced by nitrogen) and 1464kg of glacial acetic acid (the mole of undried p-aminophenol and glacial acetic acid) is added Ratio of 1:1.4) was slowly heated to about 110°C, refluxed for 3h...

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Abstract

The invention belongs to the field of preparation of organic chemical intermediate products, and particularly relates to a production system and method of acetaminophen. The production system comprises a nitrogen storage device, a batching device, an acylation device, a crystallization device and a recrystallization device. The production method comprises the steps of material preparation and dissolution, an acylation reaction, acylation acid recovery, crystallization and recrystallization. According to the method, the acetaminophen is produced by acylating refined and undried acetaminophen serving as the raw material immediately, so the drying process of refined acetaminophen is simplified, steam consumption is reduced, the labor intensity is lowered, and production benefits are improved;no catalyst needs to be added in the acylation reaction, and p-aminophenol and glacial acetic acid are directly subjected to the acylation reaction, so production cost can be saved.

Description

technical field [0001] The invention belongs to the field of preparation of organic chemical intermediate products, in particular to a production system and method for acetaminophen. Background technique [0002] p-Aminophenol, also known as hydroxyaniline, p-hydroxyaniline, PAP for short, is a colorless or light yellow flaky or needle-like crystal; it turns brown when exposed to light or in the air, soluble in hot water and alcohol, slightly soluble In cold water, almost insoluble in benzene and chloroform. PAP is a fine organic chemical intermediate with a wide range of uses: it is mainly used in the pharmaceutical industry to synthesize acetaminophen, paracetamol, clofibrate, vitamin B, and complex agent nicotinamide and other drugs. [0003] Paracetamol, APAP for short, also known as Tylenol, Panadol, Bufferin, paracetamol, is a white crystal or crystalline powder, odorless, slightly bitter taste. For cold and fever, joint pain, neuralgia and migraine, cancer pain and ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C231/02C07C231/24C07C233/25
CPCC07C231/02C07C231/24C07C233/25
Inventor 刘晓莲马宁宁董永广张志强马胜义陈红刘向军郝新庭徐亚威
Owner JIHENG PHARMA HENGSHUI CITY
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